Article
Oncology
Michael C. Brown, Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Summary: This study reveals the contribution of pre-existing anti-polio immunity to the effectiveness of polio virotherapy for cancer treatment. Childhood vaccines such as polio and tetanus can enhance antitumor immune responses, particularly by activating CD4(+) T cells and eosinophils.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Frojd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Jan Boren, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin
Summary: This case report highlights the rapid eradication of melanoma brain metastases and the development of near-fatal encephalomyelitis following double immune checkpoint blockade. The expression of ICOS on CD4+ and CD8+ T cells may play a potential role in mediating encephalomyelitis and other serious immune-related adverse events. Early diagnosis of encephalitis could be facilitated by monitoring brain damage markers in blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Saad M. Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P. Dunn, Allegra Petti, Tanner M. Johanns
Summary: Dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion in glioblastoma, influencing the efficacy of PD-1 blockade. Adding a CD40 agonist to PD-1 blockade therapy improves survival rates in glioblastoma, suggesting a potential synergistic immunotherapeutic approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Urology & Nephrology
Andrea M. Newman-Rivera, Johanna T. Kurzhagen, Hamid Rabb
Summary: Double negative (DN) T cells are a poorly studied subgroup of T lymphocytes that lack CD4 and CD8 coreceptors. They have been found in multiple organs and are able to suppress inflammatory responses in different disease models. There is evidence suggesting their important role in the pathogenesis of systemic lupus erythematosus. However, little is known about the involvement of DN T cells in other kidney diseases. Therefore, further research is needed to better understand their functions and signaling pathways.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Sung Min Choi, Hi Jung Park, Eun A. Choi, Kyeong Cheon Jung, Jae Il Lee
Summary: The study identified a diverse subset of circulating DP cells, including naive cells and various subpopulations with multiple potential functions such as CD4 CTL-, Eomes(+) Tr1-, Th2-, Th17-, Tfh-, Treg-, CD8 CTL-, and innate-like cells. In addition, flow cytometry analysis showed that a substantial number of naive DP T cells express CD8 alpha beta and CD8 alpha alpha, while subsets with high levels of CD4 co-receptor express helper and regulatory functions. Conversely, subsets with high CD8 co-receptor expression in the CD4(lo)CD8(hi) population display characteristics of CD8 CTL- and innate-like properties.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Miguel Angel Alvarez-Mon, Ana Maria Gomez-Lahoz, Arancha Orozco, Guillermo Lahera, David Diaz, Miguel A. Ortega, Agustin Albillos, Javier Quintero, Enrique Auba, Jorge Monserrat, Melchor Alvarez-Mon
Summary: Patients with major depressive disorder show abnormal distribution of Th17 and TNF-alpha expressing cells among circulating CD4(+) T lymphocytes, along with increased levels of IL-17 and TNF-alpha in the serum.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Sara Gonzalez-Rodriguez, Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Agustin Hidalgo, Segundo Gonzalez, Luis Menendez, Ana Baamonde
Summary: The study found that CCL4-induced hyperalgesia is related to the desensitization of CCR5 in CD4(+) T-cells and to the release of IL-16 from CD8(+) lymphocytes.
Article
Oncology
Selma Bekri, Reunet Rodney-Sandy, Diana Gruenstein, Anna Mei, Bjarne Bogen, John Castle, Daniel Levey, Hearn Jay Cho
Summary: This study demonstrates that a vaccine targeting a tumor-specific neoantigen efficiently induces CD4 T cell-mediated tumor protection in a mouse model. The vaccine does not directly induce cytotoxic activity in CD4 T cells, but activation of CD8 CTL against tumor-associated antigens not present in the vaccine is a major mechanism of tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hahnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Summary: In early RA patients and individuals at risk for RA, there is an increase in Tfh cells in lymphoid tissues with decreased IL-21 production.
Article
Chemistry, Analytical
Lin Zhao, Liwen Tang, Marion S. Greene, Yu Sa, Wenjin Wang, Jiahong Jin, Heng Hong, Jun Q. Lu, Xin-Hua Hu
Summary: This study investigates the structure-function relationship of CD4+ and CD8+ T cell subtypes by analyzing their morphologic features and surface CD markers. The results show a strong correlation between the structure and function of these two major T cell subtypes. Diffraction imaging flow cytometry proves to be a potential method for accurate and label-free classification of T cell subtypes.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Jara Palomero, Carla Panisello, Maria Lozano-Rabella, Ricky Tirtakasuma, Judit Diaz-Gomez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernandez, Ana Vivancos, Carlos E. de Andrea, Ignacio Melero, Jordi Ponce, August Vidal, Josep Maria Piulats, Xavier Matias-Guiu, Alena Gros
Summary: Our study investigates the prevalence, phenotype, specificity and prognostic value of tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC). We found that CD8(+)TILs expressing high levels of PD-1 and CD39 were associated with tumor reactivity and improved patient survival. The co-expression of inhibitory and activation markers on PD-1(hi) CD4(+) T cells was also observed, which accumulated antitumor T cells and correlated with prolonged survival in EC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Carlos van der Putten, Ester B. M. Remmerswaal, Matty L. Terpstra, Nelly D. van der Bom, Jesper Kers, Ineke J. M. ten Berge, Suzanne E. Geerlings, Rene A. W. van Lier, Frederike J. Bemelman, Michiel C. van Aalderen
Summary: In this study, the researchers aimed to investigate the presence and function of T-RM cells in healthy and allograft kidney tissue by analyzing the phenotype and function of T cells through multichannel flow cytometry. The results showed that kidney tissue samples contained a significant number of CD8 and CD4 T cells that were more actively cycling, expressed specific markers CXCR3 and CXCR6, produced higher levels of IFN gamma, and displayed polyfunctionality compared to circulating T cells.
Article
Oncology
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Summary: The study identified a significant presence of CD8+CD103+ TRMs in cutaneous squamous cell carcinomas, with their expression in the tumor being associated with poorer clinical outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Oncology
Amanda D. Hagstrom, Paul W. M. Marshall, Chris Lonsdale, Shona Papalia, Birinder S. Cheema, Catherine Toben, Bernhard T. Baune, Maria A. Fiatarone Singh, Simon Green
BREAST CANCER RESEARCH AND TREATMENT
(2016)
Article
Biochemistry & Molecular Biology
R. C. Culverhouse, N. L. Saccone, A. C. Horton, Y. Ma, K. J. Anstey, T. Banaschewski, M. Burmeister, S. Cohen-Woods, B. Etain, H. L. Fisher, N. Goldman, S. Guillaume, J. Horwood, G. Juhasz, K. J. Lester, L. Mandelli, C. M. Middeldorp, E. Olie, S. Villafuerte, T. M. Air, R. Araya, L. Bowes, R. Burns, E. M. Byrne, C. Coffey, W. L. Coventry, K. A. B. Gawronski, D. Glei, A. Hatzimanolis, J-J Hottenga, I. Jaussent, C. Jawahar, C. Jennen-Steinmetz, J. R. Kramer, M. Lajnef, K. Little, H. M. zu Schwabedissen, M. Nauck, E. Nederhof, P. Petschner, W. J. Peyrot, C. Schwahn, G. Sinnamon, D. Stacey, Y. Tian, C. Toben, S. Van der Auwera, N. Wainwright, J-C Wang, G. Willemsen, I. M. Anderson, V. Arolt, C. Aslund, G. Bagdy, B. T. Baune, F. Bellivier, D. I. Boomsma, P. Courtet, U. Dannlowski, E. J. C. de Geus, J. F. W. Deakin, S. Easteal, T. Eley, D. M. Fergusson, A. M. Goate, X. Gonda, H. J. Grabe, C. Holzman, E. O. Johnson, M. Kennedy, M. Laucht, N. G. Martin, M. R. Munafo, K. W. Nilsson, A. J. Oldehinkel, C. A. Olsson, J. Ormel, C. Otte, G. C. Patton, B. W. J. H. Penninx, K. Ritchie, M. Sarchiapone, J. M. Scheid, A. Serretti, J. H. Smit, N. C. Stefanis, P. G. Surtees, H. Voelzke, M. Weinstein, M. Whooley, J. I. Nurnberger, N. Breslau, L. J. Bierut
MOLECULAR PSYCHIATRY
(2018)
Article
Psychiatry
Liliana G. Ciobanu, Perminder S. Sachdev, Julian N. Trollor, Simone Reppermund, Anbupalam Thalamuthu, Karen A. Mather, Sarah Cohen-Woods, David Stacey, Catherine Toben, K. Oliver Schubert, Bernhard T. Baune
JOURNAL OF PSYCHIATRIC RESEARCH
(2018)
Article
Psychiatry
Ana C. Andreazza, Isabelle Laksono, Brisa S. Fernandes, Catherine Toben, Piotr Lewczuk, Peter Riederer, Sidney H. Kennedy, Dimitrios Kapogiannis, Florence Thibaut, Manfred Gerlach, Carla Gallo, Yong-Ku Kim, Edna Grunblatt, Lakshmi Yatham, Michael Berk, Bernhard T. Baune
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Article
Behavioral Sciences
Gaurav Singhal, Julie Morgan, Magdalene C. Jawahar, Frances Corrigan, Emily J. Jaehne, Catherine Toben, Jimmy Breen, Stephen M. Pederson, Anthony J. Hannan, Bernhard T. Baune
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Gaurav Singhal, Julie Morgan, Magdalene C. Jawahar, Frances Corrigan, Emily J. Jaehne, Catherine Toben, James Breen, Stephen M. Pederson, Anthony J. Hannan, Bernhard T. Baune
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Nils Opel, Micah Cearns, Scott Clark, Catherine Toben, Dominik Grotegerd, Walter Heindel, Harald Kugel, Anja Teuber, Heike Minnerup, Klaus Berger, Udo Dannlowski, Bernhard T. Baune
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Gaurav Singhal, Julie Morgan, Magdalene C. Jawahar, Frances Corrigan, Emily J. Jaehne, Catherine Toben, James Breen, Stephen M. Pederson, Jim Manavis, Anthony J. Hannan, Bernhard T. Baune
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Cell Biology
Gaurav Singhal, Julie Morgan, Frances Corrigan, Catherine Toben, Magdalene C. Jawahar, Emily J. Jaehne, Jim Manavis, Anthony J. Hannan, Bernhard T. Baune
Summary: In the short-term, environmental enrichment (EE) has a stronger modulatory effect on microglial and peripheral T cell subset numbers in mice compared to physical exercise (PE) and PE + EE, which shows no additive effects.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Liliana G. Ciobanu, Perminder S. Sachdev, Julian N. Trollor, Simone Reppermund, Anbupalam Thalamuthu, Karen A. Mather, Sarah Cohen-Woods, David Stacey, Catherine Toben, K. Oliver Schubert, Bernhard T. Baune
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Neurosciences
Gaurav Singhal, Julie Morgan, Magdalene C. Jawahar, Frances Corrigan, Emily J. Jaehne, Catherine Toben, Jim Manavis, Anthony J. Hannan, Bernhard T. Baune
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Tarunveer S. Ahluwalia, Bram P. Prins, Mohammadreza Abdollahi, Nicola J. Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, Jens Baumert, Marian Beekman, Yoav Ben-Shlomo, Joshua C. Bis, Braxton D. Mitchell, Eco de Geus, Graciela E. Delgado, Diana Marek, Joel Eriksson, Eero Kajantie, Stavroula Kanoni, John P. Kemp, Chen Lu, Riccardo E. Marioni, Stela McLachlan, Yuri Milaneschi, Ilja M. Nolte, Alexandros M. Petrelis, Eleonora Porcu, Maria Sabater-Lleal, Elnaz Naderi, Ilkka Seppala, Tina Shah, Gaurav Singhal, Marie Standl, Alexander Teumer, Anbupalam Thalamuthu, Elisabeth Thiering, Stella Trompet, Christie M. Ballantyne, Emelia J. Benjamin, Juan P. Casas, Catherine Toben, George Dedoussis, Joris Deelen, Peter Durda, Jorgen Engmann, Mary F. Feitosa, Harald Grallert, Ann Hammarstedt, Sarah E. Harris, Georg Homuth, Jouke-Jan Hottenga, Sirpa Jalkanen, Yalda Jamshidi, Magdalene C. Jawahar, Tine Jess, Mika Kivimaki, Marcus E. Kleber, Jari Lahti, Yongmei Liu, Pedro Marques-Vidal, Dan Mellstrom, Simon P. Mooijaart, Martina Muller-Nurasyid, Brenda Penninx, Joana A. Revez, Peter Rossing, Katri Raikkonen, Naveed Sattar, Hubert Scharnagl, Bengt Sennblad, Angela Silveira, Beate St Pourcain, Nicholas J. Timpson, Julian Trollor, Jenny van Dongen, Diana Van Heemst, Sophie Visvikis-Siest, Peter Vollenweider, Uwe Volker, Melanie Waldenberger, Gonneke Willemsen, Delilah Zabaneh, Richard W. Morris, Donna K. Arnett, Bernhard T. Baune, Dorret Boomsma, Yen-Pei C. Chang, Ian J. Deary, Panos Deloukas, Johan G. Eriksson, David M. Evans, Manuel A. Ferreira, Tom Gaunt, Vilmundur Gudnason, Anders Hamsten, Joachim Heinrich, Aroon Hingorani, Steve E. Humphries, J. Wouter Jukema, Wolfgang Koenig, Meena Kumari, Zoltan Kutalik, Deborah A. Lawlor, Terho Lehtimaki, Winfried Marz, Karen A. Mather, Silvia Naitza, Matthias Nauck, Claes Ohlsson, Jackie F. Price, Olli Raitakari, Ken Rice, Perminder S. Sachdev, Eline Slagboom, Thorkild I. A. Sorensen, Tim Spector, David Stacey, Maria G. Stathopoulou, Toshiko Tanaka, S. Goya Wannamethee, Peter Whincup, Jerome Rotter, Abbas Dehghan, Eric Boerwinkle, Bruce M. Psaty, Harold Snieder, Behrooz Z. Alizadeh
Summary: This study identified novel genetic loci influencing circulating IL-6 levels, uncovering new immunological and inflammatory pathways that may impact the pathobiology of IL-6.
HUMAN MOLECULAR GENETICS
(2021)
Article
Behavioral Sciences
Gaurav Singhal, Magdalene C. Jawahar, Julie Morgan, Frances Corrigan, Emily J. Jaehne, Catherine Toben, Anthony J. Hannan, Shalem Yiner-Lee Leemaqz, Bernhard T. Baune
Summary: TNF signaling via its receptors mediates cognition, anxiety and depressive-like behaviors independently, but does not mediate the effects of short-term exercise on these behaviors in middle-aged mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Matthew J. Knight, Ellen Lyrtzis, Celia Fourrier, Natalie Aboustate, Emma Sampson, Hikaru Hori, Micah Cearns, Julie Morgan, Catherine Toben, Bernhard T. Baune
Summary: The study aimed to evaluate an experimental treatment to improve psychosocial function in patients with Major Depressive Disorder by reinforcing cognitive, emotional, and social cognitive abilities. Findings demonstrate the efficacy of multi-domain cognitive training to improve psychosocial functioning in individuals with MDD.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
August Jernbom Falk, Cherrie Galletly, David Just, Catherine Toben, Bernhard T. Baune, Scott R. Clark, Dennis Liu, Peter Nilsson, Anna Manberg, K. Oliver Schubert
Summary: Autoimmune processes may be involved in the pathophysiology of psychotic disorders, with associations found between autoimmune IgG repertoires and clinical features of mental illness. Females and individuals with family histories of obesity or psychiatric disorders other than schizophrenia had higher overall autoantibody counts, while those with subjective thought disorder experiences or treated with clozapine had lower counts. Specific autoantibodies were linked to certain psychopathology symptoms, suggesting potential for clinical markers in patient stratification and treatment choices.
TRANSLATIONAL PSYCHIATRY
(2021)