Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues

Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

(2021) Teng Gao et al.   Nature Communications

Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences

(2020) Sushant Kumar et al.   CELL

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

(2020) Esther Rheinbay et al.   NATURE

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium

(2020) Bartomeu Colom et al.   NATURE GENETICS

The evolutionary dynamics and fitness landscape of clonal hematopoiesis

(2020) Caroline J. Watson et al.   SCIENCE

Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

(2020) Marc J Williams et al.   eLife

Monogenic and polygenic inheritance become instruments for clonal selection

(2020) Po-Ru Loh et al.   NATURE

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

Clonal haematopoiesis and risk of acute myeloid leukemia.

(2019) Andrew L. Young et al.   HAEMATOLOGICA

A pan-cancer analysis of synonymous mutations

(2019) Yogita Sharma et al.   Nature Communications

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

(2019) Marcus Danielsson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic predisposition to mosaic Y chromosome loss in blood

(2019) Deborah J. Thompson et al.   NATURE

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

(2019) Pedram Razavi et al.   NATURE MEDICINE

Extensive subclonal mutational diversity in human colorectal cancer and its significance

(2019) Lawrence A. Loeb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association

(2018) Claudia Gebhard et al.   LEUKEMIA

Somatic mutations precede acute myeloid leukemia years before diagnosis

(2018) Pinkal Desai et al.   NATURE MEDICINE

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

Prediction of acute myeloid leukaemia risk in healthy individuals

(2018) Sagi Abelson et al.   NATURE

Population dynamics of normal human blood inferred from somatic mutations

(2018) Henry Lee-Six et al.   NATURE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

The dynamics of adaptive genetic diversity during the early stages of clonal evolution

(2018) Jamie R. Blundell et al.   Nature Ecology & Evolution

Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma

(2017) Xi Liu et al.   GASTROENTEROLOGY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Identification of neutral tumor evolution across cancer types

(2016) Marc J Williams et al.   NATURE GENETICS

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

(2016) Sheng Li et al.   NATURE MEDICINE

Role of non-coding sequence variants in cancer

(2016) Ekta Khurana et al.   NATURE REVIEWS GENETICS

Excess of mutational jackpot events in expanding populations revealed by spatial Luria–Delbrück experiments

(2016) Diana Fusco et al.   Nature Communications

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis

(2015) Benjamin D. Simons   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

(2014) Fran Supek et al.   CELL

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

(2014) M R Corces-Zimmerman et al.   LEUKEMIA

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome

(2011) Kirk E. Lohmueller et al.   PLoS Genetics

Translational Selection Is Ubiquitous in Prokaryotes

(2010) Fran Supek et al.   PLoS Genetics

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL