A short peptide synthon for liquid–liquid phase separation

Reversible pH-Responsive Coacervate Formation in Lipid Vesicles Activates Dormant Enzymatic Reactions

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Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior

(2020) Benjamin S. Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

(2020) Yi Shen et al.   Nature Nanotechnology

Liquid–Liquid Phase Separation in Crowded Environments

(2020) Alain A. M. André et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

(2020) Fatma Pir Cakmak et al.   Nature Communications

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

Prebiotic Protocell Model Based on Dynamic Protein Membranes Accommodating Anabolic Reactions

(2019) Andreas Schreiber et al.   LANGMUIR

Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain

(2019) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation

(2019) Chengqian Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Physical Principles and Extant Biology Reveal Roles for RNA-Containing Membraneless Compartments in Origins of Life Chemistry

(2018) Raghav R. Poudyal et al.   BIOCHEMISTRY

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Oligonucleotide–Peptide Complexes: Phase Control by Hybridization

(2018) Jeffrey R. Vieregg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Freeze-thaw cycles induce content exchange between cell-sized lipid vesicles

(2018) Thomas Litschel et al.   NEW JOURNAL OF PHYSICS

Reversible generation of coacervate droplets in an enzymatic network

(2018) Karina K. Nakashima et al.   Soft Matter

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

(2018) Marta Tena-Solsona et al.   Nature Communications

Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle

(2018) Greg Springsteen et al.   Nature Communications

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalised RNA catalysis in membrane-free coacervate protocells

(2018) Björn Drobot et al.   Nature Communications

Towards synthetic cells using peptide-based reaction compartments

(2018) Kilian Vogele et al.   Nature Communications

The hallmarks of living systems: towards creating artificial cells

(2018) N. Amy Yewdall et al.   Interface Focus

Progress in synthesizing protocells

(2018) O Duhan Toparlak et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Spontaneous Formation of Gating Lipid Domain in Uniform-Size Peptide Vesicles for Controlled Release

(2018) Md. Mofizur Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Soft and dispersed interface-rich aqueous systems that promote and guide chemical reactions

(2018) Sandra Serrano-Luginbühl et al.   Nature Reviews Chemistry

Partitioning of Small Molecules in Hydrogen-Bonding Complex Coacervates of Poly(acrylic acid) and Poly(ethylene glycol) or Pluronic Block Copolymer

(2017) Mengmeng Zhao et al.   MACROMOLECULES

Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity

(2017) Joseph R. Simon et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Simple peptide coacervates adapted for rapid pressure-sensitive wet adhesion

(2017) Ilia Kaminker et al.   Soft Matter

Gel phase formation in dilute triblock copolyelectrolyte complexes

(2017) Samanvaya Srivastava et al.   Nature Communications

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

(2016) Timothy J. Nott et al.   Nature Chemistry

Beyond prebiotic chemistry

(2016) Leroy Cronin et al.   SCIENCE

Non-equilibrium behaviour in coacervate-based protocells under electric-field-induced excitation

(2016) Yudan Yin et al.   Nature Communications

Functional architectures based on self-assembly of bio-inspired dipeptides: Structure modulation and its photoelectronic applications

(2015) Chengjun Chen et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications

(2015) Xuejiao Zhang et al.   CHEMICAL SOCIETY REVIEWS

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles

(2015) William M. Aumiller et al.   Nature Chemistry

A recursive vesicle-based model protocell with a primitive model cell cycle

(2015) Kensuke Kurihara et al.   Nature Communications

Progress Toward Synthetic Cells

(2014) J. Craig Blain et al.   Annual Review of Biochemistry

The physical properties of supramolecular peptide assemblies: from building block association to technological applications

(2014) Lihi Adler-Abramovich et al.   CHEMICAL SOCIETY REVIEWS

A Modular Approach to Introduce Function into Single-Chain Polymeric Nanoparticles

(2014) Elisa Huerta et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels

(2014) Pim W. J. M. Frederix et al.   Nature Chemistry

Evolution of oil droplets in a chemorobotic platform

(2014) Juan Manuel Parrilla Gutierrez et al.   Nature Communications

Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate

(2013) E. Sokolova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems of Creation: The Emergence of Life from Nonliving Matter

(2012) Stephen Mann   ACCOUNTS OF CHEMICAL RESEARCH

Designs for life: protocell models in the laboratory

(2011) Alicja J. Dzieciol et al.   CHEMICAL SOCIETY REVIEWS

Peptide–nucleotide microdroplets as a step towards a membrane-free protocell model

(2011) Shogo Koga et al.   Nature Chemistry

Phase behavior of flowerlike micelles in a SCF cell model

(2008) J. Sprakel et al.   EUROPEAN PHYSICAL JOURNAL E

Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies

(2008) Matthew Biancalana et al.   JOURNAL OF MOLECULAR BIOLOGY