Review
Chemistry, Multidisciplinary
Josefa Domenech, Adriana Rodriguez-Garraus, Adela Lopez de Cerain, Amaya Azqueta, Julia Catalan
Summary: Graphene-based materials (GBMs) are a broad family of carbon-based nanomaterials widely used in nanotechnology. The potential genotoxicity of GBMs has raised concerns in terms of human health. Existing literature suggests that certain GBMs have the potential to induce genetic damage, although the specific damage type depends on the material. However, the variability in GBMs, cellular systems, and research methods used in studies makes it difficult to identify the physico-chemical properties that drive the genotoxicity response to GBMs.
Article
Chemistry, Multidisciplinary
Sneh M. Toprani, Dimitrios Bitounis, Qiansheng Huang, Nathalia Oliveira, Kee Woei Ng, Chor Yong Tay, Zachary D. Nagel, Philip Demokritou
Summary: The potential genotoxic effects of engineered nanomaterials (ENMs) on DNA repair pathways have been investigated using a fluorescence multiplex-host-cell reactivation (FM-HCR) assay. Results showed that some ENMs may enhance DNA repair capacity while others suppress it. This method can be a valuable part of a multitier, in vitro hazard assessment of ENMs, providing insights into the interplay between ENM properties, DNA repair efficiency, and genomic stability.
Article
Chemistry, Multidisciplinary
Yu-Ting Liu, Xian-Bin Li, Hui Zheng, Nian-Ke Chen, Xue-Peng Wang, Xu-Lin Zhang, Hong-Bo Sun, Shengbai Zhang
Summary: This study reports the largest scale PCM materials searching, starting with 124,515 candidate materials, and eventually screening 158 potential PCM materials using a rational high-throughput screening strategy. Further analyses revealed 52 materials with properties similar to the GST system, some of which show potential for low power consumption and suitability for optical/electrical PCM applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Sheqiang Han, Xiaodong Zhang, Qi Song, Bo Zhou, Shangwu Fan
Summary: Ammonium-ion batteries (AIBs) have gained significant attention as potential energy storage systems due to their lightweight, safety, affordability, and wide availability. Finding a fast ammonium ion conductor for AIB electrodes, which directly impacts the battery's electrochemical performance, is of great importance. Using high-throughput bond-valence calculation, we screened more than 8000 compounds in the ICSD database and identified 27 candidate electrode materials with low diffusion barriers for AIBs. These materials were further analyzed for their electrochemical properties. Our findings, which establish the relationship between structure and electrochemical properties of important electrode materials for AIBs development, could pave the way for next-generation energy storage systems.
Article
Chemistry, Physical
Miao Wang, Faquan Yu
Summary: This paper introduces a high-throughput evaluation system using phase change nanoparticles (PCMs) as taggants to label MOFs, allowing for the evaluation of multiple MOFs in one batch. The vapor adsorption of MOFs can be determined through thermogravimetric analysis (TGA) and the PCM taggant can be decoded with a differential scanning calorimeter (DSC) to correlate with MOF composition.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Zu-Jia Lu, Yong Hu, Wen-Shuai Dong, Wen-Li Cao, Ting-Wei Wang, Jian-Guo Zhang, Qi-Yao Yu
Summary: In this paper, we explored the use of high-throughput virtual screening to identify and develop novel heat-resistant high explosives. The results showed that the constructed molecular library and the precise quantum chemical calculation method were effective in synthesizing compounds with remarkable stability, suggesting their potential as high heat-resistant high explosives.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Yusu Chen, Qifeng Wang, Carolyn E. Mills, Johanna G. Kann, Kenneth R. Shull, Danielle Tullman-Ercek, Muzhou Wang
Summary: The newly developed high-throughput colorimetric adhesion screening method uses a common laboratory centrifuge, multiwell plates, and microparticles to reduce the cost of materials testing and achieve efficient screening. With its simplicity, low cost, and large dynamic range, this method has the potential to change the landscape of adhesive material characterization.
ACS CENTRAL SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Melody A. Morris, Carolyn E. Mills, Justin M. Paloni, Eric A. Miller, Hadley D. Sikes, Bradley D. Olsen
Summary: Evolution shapes diverse properties of proteins. Incorporating proteins into materials is desired for applications, but high-throughput selection techniques are lacking. This study established a high-throughput platform to assess binding affinity for ordered sensing proteins. Fusion proteins library was constructed, and selected variants showed high binding in films. The assembly of fusion proteins and the functionality of binding protein are key factors in biosensing performance. Integration of directed evolution with assembled systems is necessary for designing better materials.
Article
Chemistry, Physical
Huifang Luo, Xin Li, Yuxiang Wang, Yeqing Jin, Mingjia Yao, Jiong Yang
Summary: This study used a high-throughput workflow to screen out five room-temperature active Peltier cooling materials from 2958 Heusler materials. These materials have high electrical conductivity and large Seebeck coefficients, with effective thermal conductivity greater than copper at room temperature and ΔT = 1 K.
NPJ COMPUTATIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Mukesh Kumbhakar, Anurag Khandelwal, Shikhar Krishn Jha, Monaha Veerraju Kante, Pirmin Kessler, Uli Lemmer, Horst Hahn, Jasmin Aghassi-Hagmann, Alexander Colsmann, Ben Breitung, Leonardo Velasco, Simon Schweidler
Summary: High-throughput synthesis and characterization techniques are increasingly important for complex materials and advanced functional compounds. This study focuses on the compilation of high-entropy oxide material libraries with tunable band gaps for semiconductor applications. The material libraries include rare-earth oxides with 5, 6, and 7 different cations in near equimolar concentrations, as well as medium entropy ranges. The atmosphere used during synthesis affects the band gap, and multivalent rare-earth cations enable reversible tuning of the band gap between 2.0 and 3.5 eV under different atmospheres.
ADVANCED ENERGY MATERIALS
(2023)
Article
Multidisciplinary Sciences
Thao Ngoc Huynh, Siddharth Shukla, Philip Reigan, Roy Parker
Summary: Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease that removes poly(A) tails from the 3' end of RNAs. PARN can deadenylate certain ncRNAs, stabilizing them by preventing 3' to 5' exonucleases from accessing oligo(A) tails. Inhibitors of PARN could be used to increase p53 levels in human tumors and potentially treat cancers with suppressed p53 protein.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Shuo Shi, Guocheng Wang, Jie Liu, Sunan Liu, Qiuyu Xu, Xi Lan, Jianxing Feng, Jing Sun, Wentao Zhang, Jianlong Wang
Summary: By utilizing a flexible 3D graphene-based decoloration column, Gentiana straminea Maxim. polysaccharide was efficiently obtained and its anti-inflammatory activity was demonstrated, showcasing a promising potential for practical application in pharmaceutical field.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Guiying Xu, Jiakai Xin, Hao Deng, Ran Shi, Guangbing Zhang, Ping Zou
Summary: Thermoelectric (TE) materials are crucial for converting thermal energy into electrical energy. A new method for high-throughput screening of TE materials is proposed, based on the objective relationship among the molar Gibbs free energy, the chemical potential, the Fermi level, the electronegativity, and the TE property of a material. By calculating various TE materials, it is found that the molar Gibbs free energy and electronegativity can be used as criteria to judge the potential of materials for high-performance TE materials.
Article
Materials Science, Multidisciplinary
Mingyue Zhou, Yan Li, Chuanjin Huang, Cairen Wang, Qinghua Liu, Qibo Deng, Huixia Zhang, Tianpeng Yin, Guoyuan Zhu, Caiyun Wang, Yunfeng Zhao, Wei Zhang
Summary: Carbon nanomaterials, particularly graphene oxide (GO), have great potential in materials science and biomedicine. However, GO lamelayers tend to aggregate and are difficult to disperse in solution, resulting in low loading efficiency. To address this issue, oriented layered graphene oxide pad (OGO) was synthesized as a carrier to improve loading capacity and stability. The OGO structure showed good reproducibility and recyclability, with open channels and low pore curvature for better flow and higher fishing sites density. The CMP@OGO achieved 1.5 to 2 times higher loading capacity compared to GO. Moreover, the established CMP@OGO exhibited stability and high reuse rate, making it a promising platform for active compound screening.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Manish Kothakonda, Yanglin Zhu, Yingdong Guan, Jingyang He, Jamin Kidd, Ruiqi Zhang, Jinliang Ning, Venkatraman Gopalan, Weiwei Xie, Zhiqiang Mao, Jianwei Sun
Summary: Recent advances in 2D magnetism have led to increased interest in layered magnetic materials for spintronics applications. Layered semiconducting antiferromagnets exhibit unique low-dimensional semiconducting behavior and can be controlled by both charge and spin. However, synthesizing these compounds is challenging and rare. In this study, a high-throughput search based on first-principles was conducted to identify potentially stable mixed metal phosphorus trichalcogenides. Among the candidates, a stable semiconducting layered magnetic material, CdFeP2Se6, was successfully synthesized, exhibiting short-range antiferromagnetic order at 21 K with an indirect bandgap of 2.23 eV. This work suggests that high-throughput screening-assisted synthesis can be an effective method for discovering layered magnetic materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Valerie Forest, Jeremie Pourchez
Summary: This review discusses the application of nano-delivery systems in the treatment of respiratory diseases. Different types of nanocarriers, routes of administration, and technical aspects are detailed, and future development prospects are proposed.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Environmental Sciences
Jean-Pierre Alcaraz, Laurence Le Coq, Jeremie Pourchez, Dominique Thomas, Sandrine Chazelet, Isabelle Boudry, Maud Barbado, Sophie Silvent, Claire Dessale, Fabienne Antoine, Catherine Guimier-Pingault, Laurent Cortella, Sophie Rouif, Nathalie Bardin-Monnier, Augustin Charvet, Olivier Dufaud, Lara Leclerc, Yoann Montigaud, Coralie Laurent, Paul Verhoeven, Aurelie Joubert, Ala Bouhanguel, Yves Andres, Joel Gaffe, Donald K. Martin, Christophe Huet, Sandrine Boisset, Max Maurin, Pascal Rumeau, Frederic Charlot, Emmanuel Richaud, Alexandre Moreau-Gaudry, Vincent Bonneterre, Philippe Cinquin, Caroline Landelle
Summary: The French consortium was established to address the mask shortage during the Covid-19 pandemic by finding ways to reuse medical masks. Their workflow provided a successful method for safely reusing medical masks, contributing to waste management and providing better protection than cloth masks.
Article
Chemistry, Multidisciplinary
Mariam Chaoui, Sophie Chevrel, Sophie Perinel-Ragey, Nathalie Prevot, Jeremie Pourchez
Summary: This study assessed the performance of a new-generation high-power electronic nicotine delivery system for the administration of inhaled terbutaline. The results showed that under specific conditions, the system can deliver the same respirable dose of terbutaline and aerosol particle size distribution as a traditional jet nebulizer.
PHARMACEUTICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Henrietta Essie Whyte, Yoann Montigaud, Estelle Audoux, Paul Verhoeven, Amelie Prier, Lara Leclerc, Gwendoline Sarry, Coralie Laurent, Laurence Le Coq, Aurelie Joubert, Jeremie Pourchez
Summary: This study compared the BFE results of medical facemasks with the PFE results from non-medical facemasks, finding a correlation between the two. It was observed that PFE values were higher than BFE values due to differences in particle size distribution considered for efficiency calculation. To properly compare these test protocols for better deduction, it would be interesting to compare filtration efficiency for a similar granulometric range.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Mohamed-Nour Azzougagh, Francois-Xavier Keller, Mehmet Cici, Elodie Cabrol, Jeremie Pourchez
Summary: This research investigates ventilation and aerosol concentration in a metal additive manufacturing facility using L-PBF machine. Real-time metrology instruments were used to assess particle number concentration, revealing the impact of ventilation and human activity on particle levels. The study highlights the importance of individual protective equipment during maintenance and cleaning operations.
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2022)
Article
Environmental Sciences
Helene Niculita-Hirzel, Audrey S. Vanhove, Lara Leclerc, Francoise Girardot, Jeremie Pourchez, Severine Allegra
Summary: The increase in legionellosis incidence in the general population has raised concerns about the sources of infection, including showering. This study assessed the rate of aerosolization of Legionella pneumophila, a water pathogen, during showering with different shower systems. The results showed that the risk of exposure to viable Legionella is not expected to significantly increase with the use of water-efficient showerheads.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Critical Care Medicine
Jeremie Pourchez, Clement Mercier
LANCET RESPIRATORY MEDICINE
(2022)
Article
Chemistry, Medicinal
Etienne Bourgart, Lara Leclerc, Jeremie Pourchez, Mohamad Sleiman
Summary: This research aims to evaluate methods for measuring nicotine forms in nicotine salts and study the protonation of nicotine in aerosols post vaporization. The results show that nicotine forms are consistent between e-liquids and aerosols, indicating that e-liquids can be used as surrogates for aerosols. pH measurement is a commonly used method, while liquid-liquid extraction (LLE) has the highest variability and is the most time-consuming. Calculation of alpha(fb) from molar ratio is the most robust and versatile method.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Quentin Armand, Henrietta Essie Whyte, Paul Verhoeven, Florence Grattard, Lara Leclerc, Nicolas Curt, Sophie Perinel Ragey, Jeremie Pourchez
Summary: By simulating different wearing conditions, this study found that some medical masks can be worn for up to 8 hours without significant decrease in their bacterial filtration and breathability performance. Therefore, it is recommended to extend the usage duration of masks to reduce waste and environmental impact.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Article
Biotechnology & Applied Microbiology
Henrietta Essie Whyte, Aurelie Joubert, Lara Leclerc, Gwendoline Sarry, Paul Verhoeven, Laurence Le Coq, Jeremie Pourchez
Summary: The study investigates the impact of washing on the performance of face masks and finds that the breathability and filtration efficiency of the masks remain largely unchanged after washing. Community face masks, as a reusable and eco-friendly option, demonstrate high reliability.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2022)
Editorial Material
Respiratory System
V. Forest, J. Pourchez
Article
Biochemical Research Methods
Caroline Marie-Desvergne, Muriel Dubosson, Lara Leclerc, Catherine Campo, Dimitrios Bitounis, Valerie Forest, Jeremie Pourchez, Michele Cottier, Jean-Michel Vergnon, Adeline Tarantini, Veronique Chamel-Mossuz
Summary: In the field of biomonitoring, exhaled breath condensate (EBC) is a potential matrix for assessing inhalation exposure biomarkers non-invasively. This study compared the particulate content and elemental composition of EBC with bronchial washes (BWs) and bronchoalveolar lavages (BALs) in patients with interstitial lung diseases (ILDs). EBC was found to represent the sub-micron and nano-sized particle fractions of BAL and BW, with lower overall levels of elements. Silicon (Si) was the main component in all respiratory matrices, and levels of Si in EBC were elevated in ILD patients compared to healthy subjects. The particulate content of EBC is associated with lung particle burden and may correlate with pathologies, making it a relevant biomonitoring technique in occupational and clinical fields.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Chemistry, Medicinal
Lara Leclerc, Nathalie Prevot, Sophie Hodin, Xavier Delavenne, Heribert Mentzel, Uwe Schuschnig, Jeremie Pourchez
Summary: This study evaluated the impact of nasal delivery technique and nebulizing technologies on the targeting of maxillary sinuses with acoustic aerosol. Different devices and techniques were assessed, and the results showed that a closed soft palate and the PARI SINUS nebulizer yielded higher intrasinus aerosol deposition compared to other conditions. The choice of nebulizing technology and nasal delivery technique are crucial factors in improving aerosol deposition in the maxillary sinuses.
Article
Environmental Sciences
Marine Michon, Clement Mercier, Claudie Petit, Lara Leclerc, Laurent Bertoletti, Jeremie Pourchez, Valerie Forest
Summary: This study assessed the toxicity of e-liquids and e-cigarette aerosols on human aortic smooth muscle cells through in vitro experiments. It found that while no cytotoxicity and no ROS production was induced, a pro-inflammatory response was reported.
Article
Construction & Building Technology
Jeremie Pourchez, Aurelien Peyron, Gwendoline Sarry, Lara Leclerc, Paul O. Verhoeven, Peter Choi, Claude Pierson, Olivier Petit, Francisco Hernandez, Carmen Dumitrescu
Summary: This study evaluates the effectiveness of an innovative Atmospheric Plasma Reactor (APR) technology, which can be used in air cleaner devices, for reducing the concentration of viable airborne viruses. The results show that the APR technology can significantly reduce the virus concentration and has high virucidal activity.