Article
Pharmacology & Pharmacy
Alyssa E. Vaughn, Tanner Lehmann, Christina Sul, Alison M. Wallbank, Bailey D. Lyttle, James Bardill, Nana Burns, Anisha Apte, Eva S. Nozik, Bradford Smith, Christine U. Vohwinkel, Carlos Zgheib, Kenneth W. Liechty
Summary: This study found that CNP-miR146a can alleviate the lung inflammation caused by MRSA infection and improve the integrity of the alveolar-capillary barrier, which may become a potential therapeutic for ARDS.
Article
Nanoscience & Nanotechnology
Stephen M. Niemiec, Sarah A. Hilton, Alison Wallbank, Mark Azeltine, Amanda E. Louiselle, Hanan Elajaili, Ayed Allawzi, Junwang Xu, Courtney Mattson, Lindel C. Dewberry, Junyi Hu, Sushant Singh, Tamil S. Sakthivel, Sudipta Sea, Eva Nozik-Grayck, Bradford Smith, Carlos Zgheib, Kenneth W. Liechty
Summary: CNP-miR146a prevents acute lung injury by altering inflammation, reducing oxidative stress, and decreasing collagen deposition to ultimately improve pulmonary biomechanics.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Lindel C. Dewberry, Stephen M. Niemiec, Sarah A. Hilton, Amanda E. Louiselle, Sushant Singh, Tamil S. Sakthivel, Junyi Hu, Sudipta Seal, Kenneth W. Liechty, Carlos Zgheib
Summary: Diabetic wounds are a significant healthcare burden due to impaired wound healing caused by oxidative stress and inflammation. The synthesized CNP-miR146a, which consists of cerium oxide nanoparticles (CNP) conjugated with microRNA-146a, has been shown to improve diabetic wound healing. This is achieved through the combined effects of CNP's free radical scavenger properties and miR146a's inhibition of the inflammatory pathway. The study investigates the mechanisms by which CNP-miR146a promotes diabetic wound healing, focusing on markers of inflammation, oxidative stress, fibrosis, and angiogenesis. The results demonstrate that intradermal injection of CNP-miR146a increases wound collagen, enhances angiogenesis, and reduces inflammation and oxidative stress, leading to faster closure of diabetic wounds.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Qinqin Fei, Emily M. Shalosky, Ryelie Barnes, Vasudha C. Shukla, Siying Xu, Megan N. Ballinger, Laszlo Farkas, Robert J. Lee, Samir N. Ghadiali, Joshua A. Englert
Summary: Alveolar macrophages respond to injurious physical forces during mechanical ventilation by inducing inflammation, which is regulated by the anti-inflammatory microRNA, miR-146a. Increasing miR-146a expression to supraphysiologic levels using untargeted lipid nanoparticles reduces ventilator-induced lung injury but requires a high initial dose of miR-146a, limiting its clinical applicability. This study developed mannosylated lipid nanoparticles that effectively mitigate lung injury at the initiation of mechanical ventilation with lower doses of miR-146a.
Article
Biochemistry & Molecular Biology
Huang Huang, Jing Zhu, Lili Gu, Jiang Hu, Xiujing Feng, Weiliang Huang, Sheng Wang, Yang Yang, Ping Cui, Shao-Hsuan Lin, Andrew Suen, Briana K. Shimada, Brittney Williams, Maureen A. Kane, Yunbo Ke, Chen-Ou Zhang, Anna A. Birukova, Konstantin G. Birukov, Wei Chao, Lin Zou
Summary: Research demonstrates that TLR7 activation can induce pulmonary inflammation and endothelial barrier disruption through sensing extracellular miR-146a-5p, thus contributing to sepsis-associated acute respiratory distress syndrome.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiang-Zhi Fang, Min Li, Ya-Xin Wang, Pei Zhang, Miao-Miao Sun, Jia-Xin Xu, Yi-Yi Yang, Ya-Jun He, Yuan Yu, Rui-Ting Li, Ting Zhou, Le-Hao Reng, De-Yi Sun, Hua-Qing Shu, Shi-Ying Yuan, Ji-Qian Xu, You Shang
Summary: This study demonstrated the key role of Piezo1 in mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis. Inhibiting Piezo1 activity could attenuate ATP release and EMT process in lung epithelial cells, thus improving pulmonary fibrosis.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Peng Zhang, Baoyi Liu, Weihao Zheng, Yantang Chen, Zhentao Wu, Yuting Lu, Jie Ma, Wenjie Lu, Mingzhu Zheng, Wanting Wu, Zijie Meng, Jinhua Wu, Yan Zheng, Xin Zhang, Shuang Zhang, Yanming Huang
Summary: This study investigates the role of the lung microbiome in disease progression and potential therapeutic targets in patients with sepsis-induced acute respiratory distress syndrome (ARDS). The results show that different sites of infection and prognoses can affect the composition and diversity of the pulmonary microbiome in ARDS patients, providing insights into disease development and potential therapeutic targets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eleonore Froehlich
Summary: This review discusses pulmonary changes and treatment options for ARDS induced by viruses, focusing on the potential role of pulmonary lymphatics in the pathology. Although hyaluronan may play a role in ARDS, promising pharmacological treatments are unlikely due to the limited role of drugs in lymphedema therapy.
Article
Medicine, General & Internal
Elisa Baratella, Barbara Ruaro, Cristina Marrocchio, Natalia Starvaggi, Francesco Salton, Fabiola Giudici, Emilio Quaia, Marco Confalonieri, Maria Assunta Cova
Summary: This study evaluated HRCT findings in SARS-CoV-2-related ARDS survivors treated with prolonged low-dose methylprednisolone after discharge. The majority of patients showed alterations in pulmonary parenchyma on HRCT, with linear bands and ground glass opacities being the most common findings, symmetrically distributed with lower lobes most affected.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Zi-Ming Li, Sheng-Ya Xu, Yi-Zhuo Feng, Yu-Rui Cheng, Jian-Bing Xiong, Yong Zhou, Cha-Xiang Guan
Summary: NOX4 is a unique enzyme mainly expressed in the respiratory system, with both protective and damaging roles in different respiratory diseases. Negative and positive feedback play significant roles in regulating NOX4 expression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Renzi Zhang, Yiwen Tan, Chaoying Yong, Yang Jiao, Xumao Tang, Daoxin Wang
Summary: This study confirmed that PFD can decrease pulmonary fibrosis following ARDS by inhibiting the HH pathway to reduce EndMT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biology
Adeel Nasrullah, Shiza Virk, Aaisha Shah, Max Jacobs, Amina Hamza, Abu Baker Sheikh, Anam Javed, Muhammad Ali Butt, Swathi Sangli
Summary: COVID-19 pandemic has caused significant morbidity and mortality, especially from severe acute respiratory distress syndrome (ARDS). The management of COVID-19-associated ARDS (CARDS) involves lung-protective ventilation, prone ventilation, neuromuscular blockade, and possibly a trial of pulmonary vasodilators for refractory hypoxemia.
Article
Medicine, General & Internal
Qing Qing, Ping Zha, Li-Ying Dai, Yang Wang
Summary: This study investigated the clinical efficacy of different ventilation strategies combined with pulmonary surfactant (PS) therapy in the treatment of neonatal respiratory distress syndrome (NRDS). The findings showed that the integration of high-frequency oscillatory ventilation (HFOV) with PS effectively expedited the treatment duration, decreased the occurrence of complications, and secured therapeutic efficacy in managing NRDS.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Jong Hwan Jeong, Manbong Heo, Sunmi Ju, Seung Jun Lee, Yu Ji Cho, Yi Yeong Jeong, Jong Deog Lee, Jung-Wan Yoo
Summary: The study revealed a significant association between pulmonary mycobacterial infection and increased 28-day mortality in patients with ARDS. Patients with pulmonary mycobacterial infection had a higher rate of severe complications and required more aggressive treatment compared to those without infection.
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biophysics
Karen E. Peloi, Cesar A. Contreras Lancheros, Celso Nakamura, Sushant Singh, Craig Neal, Tamil S. Sakthivel, Sudpita Seal, Suelide Oliveira Silva Lautenschlager
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Infectious Diseases
Mona Doshi, Alexander Bosak, Craig J. Neal, Nour Isis, Udit Kumar, Aadithya Jeyaranjan, Tamil Selvan Sakthivel, Sushant Singh, Alicia Willenberg, Robert B. Hines, Sudipta Seal, Bradley J. Willenberg
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Biotechnology & Applied Microbiology
Fabianne Martins Ribeiro, Mariana Maciel de Oliveira, Sushant Singh, Tamil S. Sakthivel, Craig J. Neal, Sudipta Seal, Tania Ueda-Nakamura, Sueli de Oliveira Silva Lautenschlager, Celso Vataru Nakamura
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Biology
Sushant Singh, Muthu Periasamy, Naresh C. Bal
Summary: Comparing SLN expression and key proteins involved in Ca2+ handling and mitochondrial metabolism between FVB/N and C57BU6J mouse strains showed that SLN expression is lower in FVB/N mice. Additionally, Ca2+ transporters and electron transport chain proteins in the mitochondria were also less abundant in FVB/N mice, indicating potential differences in energy metabolism. Researchers should consider these variations when interpreting data from studies using different mouse strains in the future.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Lori M. Estes, Priyadarshini Singha, Sushant Singh, Tamil S. Sakthivel, Mark Garren, Ryan Devine, Elizabeth J. Brisbois, Sudipta Seal, Hitesh Handa
Summary: Broad-spectrum antimicrobials, formulated by combining agents with different mechanisms, show promising potential in preventing polymicrobial infections with the ability to develop coatings and films for biomedical device applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Sushant Singh, Udit Kumar, David Gittess, Tamil S. Sakthivel, Balaashwin Babu, Sudipta Seal
Summary: Nanoceria (CNPs) have shown the ability to act as regenerative ROS scavengers with potential SOD or CAT mimicry, influenced by the Ce3+/Ce4+ ratio. The presence of phosphate can reduce SOD mimetic activity, highlighting the importance of maintaining both SOD and catalase activity in a phosphate-rich environment. Characterization of CNPs in this study demonstrated good biocompatibility and efficient reduction of hydrogen peroxide under in-vitro conditions.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Engineering, Biomedical
Baltej Dhillon, Sushant Singh, Jason Keifer, Udit Kumar, Saad Shaikh, Son Ho, Sudipta Seal
Summary: The study investigated the protective effects of cerium oxide nanoparticles (CNP) on human retinal pigment epithelium cells damaged by hydroxychloroquine (HCQ), finding that CNP pre-treatment showed significant protection. This protection mechanism may involve scavenging reactive oxygen species and affecting the colocalization of autophagosomes and lysosomes.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Engineering, Biomedical
Karen Elaine Peloi, Bianca Altrao Ratti, Celso Vataru Nakamura, Craig J. Neal, Tamil Selvan Sakthivel, Sushant Singh, Sudpita Seal, Sueli de Oliveira Silva Lautenschlager
Summary: Neutrophils play a crucial role in restoring skin microenvironment homeostasis, but their activation under UV-B exposure can lead to increased production of reactive oxygen species. Engineered cerium oxide nanoparticles show potential in mitigating the effects of neutrophils' oxidative response and protecting against UV-B induced skin damage.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Nanoscience & Nanotechnology
Stephen M. Niemiec, Sarah A. Hilton, Alison Wallbank, Mark Azeltine, Amanda E. Louiselle, Hanan Elajaili, Ayed Allawzi, Junwang Xu, Courtney Mattson, Lindel C. Dewberry, Junyi Hu, Sushant Singh, Tamil S. Sakthivel, Sudipta Sea, Eva Nozik-Grayck, Bradford Smith, Carlos Zgheib, Kenneth W. Liechty
Summary: CNP-miR146a prevents acute lung injury by altering inflammation, reducing oxidative stress, and decreasing collagen deposition to ultimately improve pulmonary biomechanics.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Lindel C. Dewberry, Stephen M. Niemiec, Sarah A. Hilton, Amanda E. Louiselle, Sushant Singh, Tamil S. Sakthivel, Junyi Hu, Sudipta Seal, Kenneth W. Liechty, Carlos Zgheib
Summary: Diabetic wounds are a significant healthcare burden due to impaired wound healing caused by oxidative stress and inflammation. The synthesized CNP-miR146a, which consists of cerium oxide nanoparticles (CNP) conjugated with microRNA-146a, has been shown to improve diabetic wound healing. This is achieved through the combined effects of CNP's free radical scavenger properties and miR146a's inhibition of the inflammatory pathway. The study investigates the mechanisms by which CNP-miR146a promotes diabetic wound healing, focusing on markers of inflammation, oxidative stress, fibrosis, and angiogenesis. The results demonstrate that intradermal injection of CNP-miR146a increases wound collagen, enhances angiogenesis, and reduces inflammation and oxidative stress, leading to faster closure of diabetic wounds.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Udit Kumar, Candace R. Fox, Corbin Feit, Elayaraja Kolanthai, Jeremy Sheiber, Yifei Fu, Sushant Singh, Parag Banerjee, Griffith D. Parks, Sudipta Seal
Summary: The importance of research and development in public health has been highlighted during the COVID-19 pandemic, with a new antimicrobial fabric showing promise for enhanced antiviral protection in masks/PPE applications.
Article
Immunology
Stephen M. Niemiec, Amanda E. Louiselle, Sarah A. Hilton, Lindel C. Dewberry, Liping Zhang, Mark Azeltine, Junwang Xu, Sushant Singh, Tamil S. Sakthivel, Sudipta Seal, Kenneth W. Liechty, Carlos Zgheib
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Materials Science, Biomaterials
Sushant Singh, Gabriela Cortes, Udit Kumar, Tamil S. Sakthivel, Stephen M. Niemiec, Amanda E. Louiselle, Mark Azeltine-Bannerman, Carlos Zgheib, Kenneth W. Liechty, Sudipta Seal
BIOMATERIALS SCIENCE
(2020)
Article
Medicine, General & Internal
Jason Kieffer, Sushant Singh, Baltej S. Dhillon, Udit Kumar, Saad Shaikh, Son Ho, Sudipta Seal
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)