A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4+ T cells and is defective in Crohn´s disease patients

Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression

(2021) Raoul J. P. Bonnal et al.   NATURE IMMUNOLOGY

c-MAF, a Swiss Army Knife for Tolerance in Lymphocytes

(2020) Claire Imbratta et al.   Frontiers in Immunology

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

(2019) Esperanza Perucha et al.   Nature Communications

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

Functions and regulation of T cell-derived interleukin-10

(2019) Christian Neumann et al.   SEMINARS IN IMMUNOLOGY

Natural Tr1-like cells do not confer long-term tolerogenic memory

(2019) Koshika Yadava et al.   eLife

Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

(2018) Johanna Sophie Alfen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells

(2018) Leona Gabryšová et al.   NATURE IMMUNOLOGY

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

(2018) Norio Chihara et al.   NATURE

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

(2018) Dominik Aschenbrenner et al.   NATURE IMMUNOLOGY

Eomesodermin controls a unique differentiation program in human IL-10 and IFN-γ coproducing regulatory T cells

(2018) Paola Gruarin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders

(2018) Ali N. Kamali et al.   MOLECULAR IMMUNOLOGY

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells

(2018) Leonie Brockmann et al.   Nature Communications

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

(2016) E M Giles et al.   Mucosal Immunology

Liver sinusoidal endothelial cells induce immunosuppressive IL-10-producing Th1 cells via the Notch pathway

(2015) Katrin Neumann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+T cells

(2015) Chi-Keung Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

(2015) Stacey N. Harbour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

(2014) Ian A. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Blimp-1 in programing Th effector cells into IL-10 producers

(2014) Christian Neumann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells

(2014) M. Batten et al.   JOURNAL OF IMMUNOLOGY

Associations between STAT3 rs744166 Polymorphisms and Susceptibility to Ulcerative Colitis and Crohn's Disease: A Meta-Analysis

(2014) Jixiang Zhang et al.   PLoS One

Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells

(2013) Tatsuro Murano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+T cells

(2013) Yukiko Iwasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4+T cells

(2013) Béatrice Corre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

(2013) David Ellinghaus et al.   GASTROENTEROLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

Hes1 Desynchronizes Differentiation of Pluripotent Cells by Modulating STAT3 Activity

(2013) Xinzhi Zhou et al.   STEM CELLS

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Interleukin-6 induces the generation of IL-10-producing Tr1 cells and suppresses autoimmune tissue inflammation

(2012) Jun-O Jin et al.   JOURNAL OF AUTOIMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Th17-related cytokines: new players in the control of chronic intestinal inflammation

(2011) Ivan Monteleone et al.   BMC Medicine

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

IL-10 production by CD4+ effector T cells: a mechanism for self-regulation

(2010) D Jankovic et al.   Mucosal Immunology

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

(2009) Margarida Saraiva et al.   IMMUNITY

Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

(2009) N. Kassner et al.   JOURNAL OF IMMUNOLOGY

IL-21 Mediates Suppressive Effects via Its Induction of IL-10

(2009) R. Spolski et al.   JOURNAL OF IMMUNOLOGY

c-Maf Regulates IL-10 Expression during Th17 Polarization

(2009) Jiangnan Xu et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Notch regulates IL-10 production by T helper 1 cells

(2008) S. Rutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling

(2008) Gabriella Regis et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY