Autophagic Activation and Decrease of Plasma Membrane Cholesterol Contribute to Anticancer Activities in Non-Small Cell Lung Cancer

Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma

(2019) Fahim Ahmad et al.   Cancers

Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells

(2018) Juan Zeng et al.   BMC CANCER

Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis

(2018) Xiaojing Lin et al.   Nutrients

Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy

(2018) Wei Wu et al.   Frontiers in Pharmacology

Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study

(2018) Wei-Jie Guan et al.   Journal of Thoracic Disease

Overcoming resistance in non-small-cell lung cancer: A practical lesson for the medicinal chemist

(2018) Giovanni Ribaudo et al.   ARCHIV DER PHARMAZIE

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells

(2018) Ugo Testa et al.   Cancers

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

(2018) Raquel Lima et al.   MOLECULES

Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs

(2018) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents

(2018) Jui-Ling Hsu et al.   Frontiers in Pharmacology

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

(2017) Walaa Eid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

Effects of para–toluenesulfonamide intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: A multi-center, non-randomized, single-arm, open-label trial

(2016) Shi-yue Li et al.   LUNG CANCER

Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability

(2015) Zhe Liu et al.   ANTI-CANCER DRUGS

Translational control by oncogenic signaling pathways

(2015) Beichen Gao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

(2014) Yi-Fang Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function

(2014) Laura A. Martin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function

(2013) Brian P. Head et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

The Prognostic Value of Phosphorylated AKT Expression in Non-Small Cell Lung Cancer: A Meta-Analysis

(2013) Zhi-Xin Qiu et al.   PLoS One

Translational Homeostasis via eIF4E and 4E-BP1

(2012) Alan G. Hinnebusch   MOLECULAR CELL

Mitochondrial Fusion Is Essential for Steroid Biosynthesis

(2012) Alejandra Duarte et al.   PLoS One

Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma

(2012) Qing He   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary cholesterol intake and cancer

(2011) J. Hu et al.   ANNALS OF ONCOLOGY

Activation of mammalian target of rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma

(2011) Dan Liu et al.   CANCER

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways

(2011) Jun-ichi Hanai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overexpression of the mammalian target of rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: A verification study

(2011) K. Gately et al.   LUNG CANCER

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

(2011) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress

(2010) María I. Ayuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Akt Signaling by Exclusion from Lipid Rafts in Normal and Transformed Epidermal Keratinocytes

(2010) Damien Calay et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gemcitabine plus cisplatin chemotherapy with concurrent para-toluenesulfonamide local injection therapy for peripherally advanced nonsmall cell lung cancer larger than 3 cm in the greatest dimension

(2009) Jianxing He et al.   ANTI-CANCER DRUGS

Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells

(2009) Keiichi Motoyama et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibitors of the PI3K/Akt/mTOR Pathway: New Hope for Breast Cancer Patients

(2009) Sandra Ghayad et al.   Recent Patents on Anti-Cancer Drug Discovery

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

(2008) J. Montero et al.   CANCER RESEARCH