Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies

Future scenarios for the COVID-19 pandemic

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In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins

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Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor

(2021) Ahmed A. Al-Karmalawy et al.   Frontiers in Chemistry

Revisiting Activity of Some Nocodazole Analogues as a Potential Anticancer Drugs Using Molecular Docking and DFT Calculations

(2021) Muhammad Khattab et al.   Frontiers in Chemistry

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate

(2021) Raya Soltane et al.   Pathogens

Pharmacophore‐linked pyrazolo[3,4‐ d ]pyrimidines as EGFR‐TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies

(2021) Ahmed A. Gaber et al.   ARCHIV DER PHARMAZIE

From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity

(2021) Mohamed H. El-Shershaby et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Proteome Based Approach Defines Candidates for Designing a Multitope Vaccine against the Nipah Virus

(2021) Mohamed A. Soltan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization

(2021) Ayman Abo Elmaaty et al.   MOLECULES

Bioassay-guided isolation of a new cytotoxic ceramide from Cyperus rotundus L.

(2021) Reham M. Samra et al.   SOUTH AFRICAN JOURNAL OF BOTANY

In Silico Prediction of a Multitope Vaccine against Moraxella catarrhalis: Reverse Vaccinology and Immunoinformatics

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Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2

(2021) Ahmed Kandeil et al.   Pathogens

Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies

(2021) Ahmed A. Zaki et al.   Journal of Traditional and Complementary Medicine

Lack of Antiviral Activity of Darunavir against SARS-CoV-2

(2020) Sandra De Meyer et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as coronavirus disease 2019 (COVID-19) pandemic: A global health emergency

(2020) Thamina Acter et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

Design and discovery of new 1,2,4‐triazolo[4,3‐ c ]quinazolines as potential DNA intercalators and topoisomerase II inhibitors

(2020) Mohamed S. Alesawy et al.   ARCHIV DER PHARMAZIE

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2

(2020) Ahmed Mostafa et al.   Pharmaceuticals

Prenatal exposure to mercury in relation to infant infections and respiratory symptoms in the New Hampshire Birth Cohort Study

(2019) Rebecca T. Emeny et al.   ENVIRONMENTAL RESEARCH

Computational Approaches for Drug Discovery

(2019) Brogi   MOLECULES

The Role of the Anti-Inflammatory Cytokine Interleukin-10 in Tissue Fibrosis

(2019) Emily H. Steen et al.   Advances in Wound Care

Resveratrol Modulates miR-34a in Cardiotoxicity Induced by Isoproterenol

(2019) Sylvia A. Boshra   JOURNAL OF MEDICINAL FOOD

Corrigendum to ‘Panton-Valentine Leucocidin (PVL) Staphylococcus aureus a position statement from the International Society of Chemotherapy’ [International Journal of Antimicrobial Agents 51/1 (2018) 16-25]

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Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro

(2018) Licong Yang et al.   Nanoscale Research Letters

Molecular Docking: Challenges, Advances and Its Use in Drug Discovery Perspective

(2018) Surovi Saikia et al.   CURRENT DRUG TARGETS

Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats

(2018) Sarwat Jahan et al.   BMC Urology

Lung Function Assessment as an Early Biomonitor of Mercury-Induced Health Disorders in Artisanal and Small-Scale Gold Mining Areas in Indonesia

(2018) Sri Pateda et al.   International Journal of Environmental Research and Public Health

Anti-inflammatory and ameliorative effects of gallic acid on fluoxetine-induced oxidative stress and liver damage in rats

(2017) Omid Karimi-Khouzani et al.   Pharmacological Reports

Synthesis and cytotoxic activity of certain trisubstituted azetidin-2-one derivatives as a cis-restricted combretastatin A-4 analogues

(2016) Salwa Elmeligie et al.   ARCHIVES OF PHARMACAL RESEARCH

Leaf and fruit essential oil compositions of Pimenta guatemalensis (Myrtaceae) from Costa Rica

(2015) Carlos Chaverri et al.   REVISTA DE BIOLOGIA TROPICAL

High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer

(2015) Karol Czubak et al.   Oncotarget

Protective effect of curcumin against heavy metals-induced liver damage

(2014) Wylly Ramsés García-Niño et al.   FOOD AND CHEMICAL TOXICOLOGY

Rutin decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK–NF-κB pathway

(2014) Chung-Hsin Yeh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice

(2014) Mahmut Sozmen et al.   Journal of Veterinary Science

Effect of rutin against gastric esophageal reflux in experimental animals

(2014) Sanjit Kumar et al.   TOXICOLOGY MECHANISMS AND METHODS

Synthesis of new 1,3,4-benzotriazepin-5-one derivatives and their biological evaluation as antitumor agents

(2013) Azza T. Taher et al.   ARCHIVES OF PHARMACAL RESEARCH

Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

(2013) Shengxi Meng et al.   Evidence-based Complementary and Alternative Medicine

Ferulic acid: Pharmacological and toxicological aspects

(2013) Cesare Mancuso et al.   FOOD AND CHEMICAL TOXICOLOGY

The Role of Cyclooxygenase-2 in Mechanical Ventilation–Induced Lung Injury

(2012) Joshua A. Robertson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Medicinal Properties of the Jamaican Pepper Plant Pimenta dioica and Allspice

(2012) Lei Zhang et al.   CURRENT DRUG TARGETS

High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer

(2012) Miaomiao Yang et al.   EUROPEAN JOURNAL OF CANCER

Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice

(2012) Janakiraman Shanthakumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phytochemical Analysis and Antimicrobial, Antinociceptive, and Anti-Inflammatory Activities of Two Chemotypes ofPimenta pseudocaryophyllus(Myrtaceae)

(2012) Joelma Abadia Marciano de Paula et al.   Evidence-based Complementary and Alternative Medicine

Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophages

(2012) Tatiana Fernanda Bachiega et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN

(2012) Zhi-Li Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis

(2012) Naglaa M El-Lakkany et al.   Parasites & Vectors

Composition and antioxidant activity of essential oil of pimento (Pimenta dioica(L) Merr.) from Jamaica

(2011) K.P. Padmakumari et al.   NATURAL PRODUCT RESEARCH

Anti-inflammatory activity of extracts from fruits, herbs and spices

(2010) Monika Mueller et al.   FOOD CHEMISTRY

Anti-Inflammatory Effects of Rosmarinus officinalis Essential Oil in Mice

(2009) Štefan Juhás et al.   ACTA VETERINARIA BRNO

Anti-Inflammatory and Antinociceptive Effects of Rosmarinus officinalis L. Essential Oil in Experimental Animal Models

(2008) I. Takaki et al.   JOURNAL OF MEDICINAL FOOD

Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma

(2008) Gopalakrishnan Ramakrishnan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY