Article
Chemistry, Medicinal
Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Alessandro Cama, Alessandra Acquaviva, Maria Loreta Libero, Sheila Leone, Simonetta Cristina Di Simone, Ester Pagano, Gokhan Zengin, Luigi Menghini, Luigi Brunetti, Angelo Antonio Izzo, Giustino Orlando, Claudio Ferrante
Summary: This study investigated the phenolic composition and protective effects of a water extract of grape pomace in colorectal cancer cells and isolated mouse colon. The results showed that the extract decreased cell viability, inhibited inflammatory gene expression, and increased antioxidant gene expression. These effects could be attributed to the phenolic composition, especially catechin, in grape pomace.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Applied
Diletta Balli, Lorenzo Cecchi, Marzia Innocenti, Maria Bellumori, Nadia Mulinacci
Summary: This study focused on pasta fortified with grape pomace or olive pomace, which retained phenolic compounds after cooking and increased fiber content. The enriched pasta showed good cooking resistance and texture, enhancing the nutritional profile of a staple food.
Article
Food Science & Technology
Matteo Perra, Gianluigi Bacchetta, Aldo Muntoni, Giorgia De Gioannis, Ines Castangia, Hiba N. Rajha, Maria Letizia Manca, Maria Manconi
Summary: This review provides an outlook on the resources and products that can be obtained through the recovery of grape pomace, along with the analysis of chemical, physical, and biotechnological processes. Special attention is given to the manufacturing of high-value compounds and products, such as supplements, nutraceuticals, and cosmeceuticals. The review also updates the composition of grape pomace and analyzes its traditional fate, as well as discusses modern and green sustainable management approaches.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biotechnology & Applied Microbiology
Maria Belenioti, Eirini Mathioudaki, Evrykleia Spyridaki, Demetrios Ghanotakis, Nikolaos Chaniotakis
Summary: Grape pomace is a significant issue in the Greek wine industry due to its negative environmental impact. However, by using Chlamydomonas reinhardtii, the polyphenols in grape pomace can be efficiently reduced, and the resulting product has potential as a soil conditioner.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Jiao Feng, Niels Nieuwenhuizen, Ross Atkinson, Wu Wang, Jingjue Zeng, Huan Zheng, Jianmin Tao
Summary: Phenolic compounds in grape skins contribute to the astringency of the fruit. This study examined the relationship between phenolic composition and astringency in six commercial grape varieties. Analysis of phenolic profiles identified 30 compounds, and the intensity of astringency was found to be positively correlated with catechin and other proanthocyanidins. Catechin was identified as the compound most strongly correlated with grape skin astringency. Practical application of these findings may help in predicting the astringency of table grape berries.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Plant Sciences
Guillermo F. Padilla-Gonzalez, Esther Grosskopf, Nicholas J. Sadgrove, Monique S. J. Simmonds
Summary: Grape seeds are rich in flavan-3-ol compounds, especially B-type procyanidins and monomers such as catechin and epicatechin. This review provides an overview of the existing literature on grape seed chemistry, exploring the variations in chemistry, signs of adulteration, and factors influencing metabolite expression. The research suggests that the expression of these compounds is primarily influenced by genotype and environment.
Article
Plant Sciences
Suwen Lu, Yaxian Zhuge, Tianyi Hao, Zhongjie Liu, Mengwei Zhang, Jinggui Fang
Summary: In this study, 47 OMT members were identified in the grape genome and their characteristics, distribution, expression, and regulation were investigated. The results showed that some OMT members are involved in the synthesis of methylated flavonoids and play important roles in the growth and defense of grapes.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Food Science & Technology
Nawel Benbouguerra, Ruth Hornedo-Ortega, Francois Garcia, Toni El Khawand, Cedric Saucier, Tristan Richard
Summary: Stilbenes are natural phenolic compounds synthesized by plants in response to stress. They are found in grape berries and wine, with potential anti-obesity effects. Optimized analytical methods are essential for accurate detection and quantification of stilbenes.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Agronomy
Zhilei Wang, Ying Wang, Dong Wu, Miao Hui, Xing Han, Tingting Xue, Fei Yao, Feifei Gao, Xiao Cao, Hua Li, Hua Wang
Summary: This study evaluated cold resistance of 124 wine grape germplasms by determining their low-temperature half-lethal temperature (LT50) values, clustering them into different types based on cold resistance levels and exploring cold regionalization for wine grape cultivation in China. Strong cold-resistant V. vinifera germplasms were identified for potential breeding, and the results suggested the possibility of cultivating wine grapes without winter burial overwintering in some areas of China.
Article
Biology
Xiangru Chen, Fang Yang, Chunwei Bai, Qianrui Shi, Shan Hu, Xianying Tang, Lijuan Peng, Haixia Ding
Summary: This study confirms that Bacillus velezensis strain GUMT319 is a plant growth-promoting rhizobacteria that increases grape yield. By analyzing soil properties and microbial composition, it was found that GUMT319 altered the physical and chemical properties and microbial community composition of the soil. The results suggest that GUMT319 acts as both a biocontrol agent and a plant growth-promoting rhizobacteria, improving grape yield by modifying the soil environment.
Article
Horticulture
Wenxin Li, Chang He, Hongli Wei, Jiakang Qian, Jiannan Xie, Zhiqian Li, Xianbo Zheng, Bin Tan, Jidong Li, Jun Cheng, Wei Wang, Xia Ye, Jiancan Feng
Summary: This study provides a comprehensive analysis of the grapevine pectin lyase gene family and reveals the important role of VvPL11 in fruit softening.
Article
Agriculture, Multidisciplinary
Suwen Lu, Jiayang Wang, Yaxian Zhuge, Mengwei Zhang, Chang Liu, Haifeng Jia, Jinggui Fang
Summary: This study integrated multi-omics data to explore global metabolic and transcriptional profiles in grape skins and pulps, revealing large-scale differences in the flavonoid metabolic pathway. The identified flavonoids, including flavone and flavone C-glycosides, showed a positive correlation with anthocyanins in grapes. The study also identified novel transcription factors and ubiquitin proteins as promising regulatory candidates for flavonoid biosynthesis in grapes, providing valuable information for the development of grape health products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Horticulture
Zhen Gao, Yajun Tong, Chengchao Zheng, Heng Zhai, Yuxin Yao, Yuanpeng Du
Summary: RNA-Seq analysis of dark-treated grape leaves revealed that shading/dark stress affects sucrose metabolism and cell wall degradation, resulting in smaller leaf size. Additionally, lower auxin content contributes to the inhibition of grape leaves under dark conditions.
SCIENTIA HORTICULTURAE
(2021)
Article
Plant Sciences
Jing Cheng, Keji Yu, Ying Shi, Jun Wang, Changqing Duan
Summary: The study identified an R2R3-MYB TF, VviMYB86, which positively regulates PA biosynthesis but negatively regulates anthocyanin synthesis in grape berries.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Forestry
Ling Su, Meng Qi, Dong Meng, Qing Yang, Yongmei Wang, Fengshan Ren, Liying Yang, Yingchun Chen, Liyuan Liu, Meiling Tang, Yangbo Song, Lei Gong
Summary: In order to cultivate different grape varieties according to market needs, it is important to study the regulation mechanism of color changes in grapes at different development stages. This study used RNA-sequencing technology to compare and analyze the transcriptome data of four grape varieties at the same development stage. The anthocyanin synthesis pathway in the flavonoid pathway was mainly studied among the annotated differential genes. The role of the MYB transcription factor MYB2 in anthocyanin regulation was confirmed through subcellular localization and gene function verification.
Article
Biochemistry & Molecular Biology
Saida Sissi, Silvia Di Giacomo, Claudio Ferrante, Paola Angelini, Alberto Macone, Anna Maria Giusti, Chiara Toniolo, Annabella Vitalone, Aghraz Abdellah, Mustapha Larhsini, Luigi Menghini, Mohammed Markouk, Gabriela Mazzanti, Antonella Di Sotto
Summary: In this study, the phytochemical composition and bioactivities of A. maroccanus and A. radiatus were investigated, revealing their high content of polyphenols and flavonoids. These plants demonstrated antioxidant, hypoglycemic, antiglycative, and antibacterial activities. The results provide scientific evidence for the ethnopharmacological use of these plants and suggest their potential as natural sources for pharmaceutical and nutraceutical developments.
Article
Biochemistry & Molecular Biology
Rosalba Florio, Barbara De Filippis, Serena Veschi, Viviana di Giacomo, Paola Lanuti, Giulia Catitti, Davide Brocco, Annalisa di Rienzo, Amelia Cataldi, Ivana Cacciatore, Rosa Amoroso, Alessandro Cama, Laura De Lellis
Summary: Pancreatic cancer has limited response to current therapeutic options, so there is a need for more effective and low-toxic agents. In this study, the antiproliferative activities of newly synthetized resveratrol analogues in pancreatic cancer cell lines were explored. The most active compound exhibited marked antiproliferative effects through mechanisms involving DNA damage, apoptosis induction, and interference in cell cycle progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura Serventi, Giancarlo Angeles Flores, Gaia Cusumano, Davide Barbaro, Bruno Tirillini, Roberto Venanzoni, Paola Angelini, Alessandra Acquaviva, Simonetta Cristina Di Simone, Giustino Orlando, Gokhan Zengin, Luigi Menghini, Claudio Ferrante
Summary: This study focuses on the biological and medical potentials of hydroalcoholic extracts from different parts of the Cannabis sativa plant, specifically the leaves and inflorescences. The extracts showed strong antioxidant and antimicrobial effects, with particular efficacy against Escherichia coli and Bacillus subtilis. This could be attributed to the presence of benzoic acid and cannabidiolic acid in the extracts.
Article
Biochemistry & Molecular Biology
Francesco Cairone, Caterina Fraschetti, Luigi Menghini, Gokhan Zengin, Antonello Filippi, Maria Antonietta Casadei, Stefania Cesa
Summary: Based on analysis and color analysis, it was found that the harvest year, freezing, homogenization, and thermic treatments have an impact on the bioactive components of sour cherries. The main polyphenolic components are anthocyanin compounds, primarily cyanidin-3-glucosyl-rutinoside, and immediate post-harvest freezing is the best way to preserve the bioactive content, color expression, and anti-radical activity.
Article
Food Science & Technology
Lucia Recinella, Maria Loreta Libero, Valentina Citi, Annalisa Chiavaroli, Alma Martelli, Roberta Foligni, Cinzia Mannozzi, Alessandra Acquaviva, Simonetta Di Simone, Vincenzo Calderone, Giustino Orlando, Claudio Ferrante, Serena Veschi, Anna Piro, Luigi Menghini, Luigi Brunetti, Sheila Leone
Summary: Multiple studies have shown that aged black garlic has anti-inflammatory, antioxidant, and cardioprotective effects. This study investigated the protective effects of aged black garlic extract (ABGE) alone or in combination with multivitamins on mouse hearts exposed to E. coli lipopolysaccharide. The study also examined the hydrogen sulfide releasing properties and membrane hyperpolarization effect of the formulation composed of ABGE and multivitamins using human aortic smooth muscle cells (HASMCs). The results showed that ABGE, vitamins D and C, and the formulation suppressed the expression of inflammatory genes on mouse hearts and the formulation increased intracellular hydrogen sulfide formation, suggesting its potential use in cardiovascular disease.
Article
Plant Sciences
Annalisa Chiavaroli, Maria Loreta Libero, Simonetta Cristina Di Simone, Alessandra Acquaviva, Nilofar, Lucia Recinella, Sheila Leone, Luigi Brunetti, Donatella Cicia, Angelo Antonio Izzo, Giustino Orlando, Gokhan Zengin, Abdullahi Ibrahim Uba, Ugur Cakilcioglu, Muzaffer Mukemre, Omer Elkiran, Luigi Menghini, Claudio Ferrante
Summary: This study investigated the chemical composition and bio-pharmacological properties of Pelargonium quercetorum extracts. The extracts showed different phytochemical contents and exhibited antioxidant and cytotoxic effects. The ethyl acetate extract was particularly effective against colon cancer cells and inhibited the gene expression of COX-2 and TNF alpha. These findings suggest that further studies should be conducted to explore the protective effects of these extracts against gut inflammatory diseases.
Article
Chemistry, Medicinal
Lucia Recinella, Barbara De Filippis, Maria Loreta Libero, Alessandra Ammazzalorso, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Letizia Giampietro, Serena Veschi, Alessandro Cama, Federica Mannino, Irene Gasparo, Alessandra Bitto, Rosa Amoroso, Luigi Brunetti, Sheila Leone
Summary: The effects of four new PPAR ligands on inflammation and oxidative stress were investigated, and one of them showed potential as a valuable pharmacological tool.
Article
Nutrition & Dietetics
Ester Percaccio, Marta De Angelis, Alessandra Acquaviva, Giovanna Nicotra, Claudio Ferrante, Gabriela Mazzanti, Silvia Di Giacomo, Lucia Nencioni, Antonella Di Sotto
Summary: Respiratory viral infections are challenging for susceptible and immunocompromised individuals. The study developed a mixture of Echinacea purpurea and Humulus lupulus extracts with antioxidant, cytoprotective, immunomodulating, and antiviral activities. Nrf2 activation may play a role in these properties. Further research can increase interest in this product.
Article
Microbiology
Paola Angelini, Giancarlo Angeles Flores, Gaia Cusumano, Roberto Venanzoni, Roberto Maria Pellegrino, Gokhan Zengin, Simonetta Cristina Di Simone, Luigi Menghini, Claudio Ferrante
Summary: This research investigated the impact of different substrates on the metabolite compositions of Hypsizygus marmoreus mycelia, and found that extracts from substrates enriched with barley malt or grape pomace demonstrated high antibacterial activity against various strains. Extracts from mushroom cultivated in grape pomace-enriched substrate also showed remarkable efficacy against Trichophyton mentagrophytes and T. tonsurans. This study contributes to the understanding of the cultivation of H. marmoreus.
Article
Plant Sciences
Alessandra Acquaviva, Simonetta Cristina Di Simone, Abdelhakim Nilofar, Abdelhakim Bouyahya, Gokhan Zengin, Lucia Recinella, Sheila Leone, Luigi Brunetti, Abdullahi Ibrahim Uba, Osman Guler, Maruf Balos, Ugur Cakilcioglu, Luigi Menghini, Claudio Ferrante, Giustino Orlando, Maria Loreta Libero, Annalisa Chiavaroli
Summary: Plants from the Nepeta genus, particularly Nepeta italica, have been found to possess various pharmacological properties, including analgesic effects. The polar extracts of N. italica are rich in phenolic compounds, especially rosmarinic acid. These extracts exhibit strong scavenging/reducing and enzyme inhibition effects, as well as significant anti-inflammatory effects in mouse colon.
Article
Biochemistry & Molecular Biology
Kassim Bakar, Nilofar, Andilyat Mohamed, Lukasz Swiatek, Benita Hryc, Elwira Sieniawska, Barbara Rajtar, Claudio Ferrante, Luigi Menghini, Gokhan Zengin, Malgorzata Polz-Dacewicz
Summary: This study conducted comprehensive chemical profiling and biological tests of Vepris boiviniana extracts from different parts. The results indicate that the extracts have potential antioxidant, enzyme inhibitory, and cytotoxicity activities, making them promising for cancer treatment.
Article
Cell Biology
Lucia Recinella, Maria Loreta Libero, Serena Veschi, Anna Piro, Guya Diletta Marconi, Francesca Diomede, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Rosalba Florio, Alessia Lamolinara, Renzhi Cai, Wei Sha, Andrew V. Schally, Roberto Salvatori, Luigi Brunetti, Sheila Leone, Markus Fendt
Summary: This study investigated the effects of a GHRH antagonist, MIA-602, on emotional disorders and explored the underlying mechanisms. The results showed that MIA-602 treatment and GHRH gene deficiency were associated with anxiolytic and antidepressant behavior. Additionally, the study found that MIA-602 treatment activated Nrf2, HO1, and NQO1, while downregulating COX-2, iNOS, NFkB, and TNF-alpha expressions. These findings suggest a dysregulation of neural pathways caused by GHRH gene deficiency, which is mimicked by GHRH antagonist treatment.