Multi-Targeted Molecular Docking, Pharmacokinetics, and Drug-Likeness Evaluation of Okra-Derived Ligand Abscisic Acid Targeting Signaling Proteins Involved in the Development of Diabetes

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

(2021) Abd Elmoneim O. Elkhalifa et al.   MOLECULES

Development and Characterization of Novel Biopolymer Derived from Abelmoschus esculentus L. Extract and Its Antidiabetic Potential

(2021) Abd Elmoneim O. Elkhalifa et al.   MOLECULES

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

(2020) Syed Amir Ashraf et al.   MOLECULES

Structural Properties, Bioactivities, and Applications of Polysaccharides from Okra [Abelmoschus esculentus (L.) Moench]: A Review

(2020) Xiu-mei Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow

(2020) Younghun Jung et al.   NEOPLASIA

Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants

(2019) Siba Shanak et al.   Evidence-based Complementary and Alternative Medicine

Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus

(2019) Takanori Koike et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Abscisic acid identification in Okra, Abelmoschus esculentus L. (Moench): perspective nutraceutical use for the treatment of diabetes

(2019) Patricia Daliu et al.   NATURAL PRODUCT RESEARCH

Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

(2018) Or Gertman et al.   Scientific Reports

Abelmoschus esculentus (L.): Bioactive Components’ Beneficial Properties—Focused on Antidiabetic Role—For Sustainable Health Applications

(2018) Alessandra Durazzo et al.   MOLECULES

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening

(2016) Vincent Zoete et al.   Journal of Chemical Information and Modeling

Synthesis and optimization of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors

(2015) Je Ho Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes

(2013) Thomas Böhme et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

(2013) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Structure and Biochemical Functions of SIRT6

(2011) Patricia W. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

11β-Hydroxysteroid dehydrogenase type 1 inhibition in type 2 diabetes mellitus

(2010) G. Hollis et al.   DIABETES OBESITY & METABOLISM

11 -Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle

(2009) S. A. Morgan et al.   DIABETES

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks

(2008) L. Agius   DIABETES

Structural analysis of human glutamine:fructose-6-phosphate amidotransferase, a key regulator in type 2 diabetes

(2008) Yuichiro Nakaishi et al.   FEBS LETTERS

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE