Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells

Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age?

(2021) Jiajie Hou et al.   Nature Reviews Clinical Oncology

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

(2021) Karen Slattery et al.   Journal for ImmunoTherapy of Cancer

Bifunctional TGF-β trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors

(2021) Bai Liu et al.   MOLECULAR THERAPY

Optimising NK cell metabolism to increase the efficacy of cancer immunotherapy

(2021) Chloe Choi et al.   Stem Cell Research & Therapy

A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy

(2021) Michelle K. Becker-Hapak et al.   Cancer Immunology Research

Accelerated aging in breast cancer survivors and its association with mortality and cancer recurrence

(2020) Jingjing Zhu et al.   BREAST CANCER RESEARCH AND TREATMENT

PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15

(2020) Kyung Hwan Kim et al.   Cellular & Molecular Immunology

Cellular Responses to Platinum-Based Anticancer Drugs and UVC: Role of p53 and Implications for Cancer Therapy

(2020) David Murray et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies

(2020) Lynda Wyld et al.   Cancers

Lingering effects of chemotherapy on mature T cells impair proliferation

(2020) Rajat K. Das et al.   Blood Advances

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis

(2019) Jordi Pijuan et al.   Frontiers in Cell and Developmental Biology

Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival

(2019) Crystal A. Tonnessen-Murray et al.   JOURNAL OF CELL BIOLOGY

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

TPL2 kinase action and control of inflammation

(2018) Daqi Xu et al.   PHARMACOLOGICAL RESEARCH

Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)

(2018) Jeriel T.R. Keeney et al.   Oncotarget

The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

(2018) Maja Milanovic et al.   TRENDS IN CELL BIOLOGY

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE)

(2017) Nickhill Bhakta et al.   LANCET

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

(2017) Paul J Brighton et al.   eLife

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

(2016) Megan K. Ruhland et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

(2015) Lorenzo Galluzzi et al.   CANCER CELL

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Natural Killer Cell Mediated Antibody-Dependent Cellular Cytotoxicity in Tumor Immunotherapy with Therapeutic Antibodies

(2013) Ursula J. E. Seidel et al.   Frontiers in Immunology

Senescence: a new weapon for cancer therapy

(2012) Juan Carlos Acosta et al.   TRENDS IN CELL BIOLOGY

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY