A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL‐13Rα2‐mediated JNK‐AP‐1 signals

Selection and Characterization of YKL-40-Targeting Monoclonal Antibodies from Human Synthetic Fab Phage Display Libraries

(2020) Kyungjae Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

K284-6111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway

(2020) Hyeon Joo Ham et al.   Journal of Neuroinflammation

Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway

(2019) Ji Han et al.   Marine Drugs

Decreased Lung Tumor Development in SwAPP Mice through the Downregulation of CHI3L1 and STAT 3 Activity via the Upregulation of miRNA342-3p

(2019) Dong Hun Lee et al.   Molecular Therapy-Nucleic Acids

Structure-Based Virtual Screening, Compound Synthesis, and Bioassay for the Design of Chitinase Inhibitors

(2018) Yawen Dong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer

(2018) Biao Geng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

(2018) Ji Yeon Choi et al.   Journal of Neuroinflammation

Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1

(2018) Ki Cheon Kim et al.   Theranostics

IL13RA2 targeted alpha particle therapy against glioblastomas

(2017) Anirudh Sattiraju et al.   Oncotarget

MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain

(2017) Dong Ju Son et al.   Theranostics

Role of chitinase-like proteins in cancer

(2016) Julia Kzhyshkowska et al.   BIOLOGICAL CHEMISTRY

Elevated Serum Concentration of Chitinase 3-Like 1 is an Independent Prognostic Biomarker for Poor Survival in Lung Cancer Patients

(2016) Jiying Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

(2016) Chang-Min Lee et al.   Nature Communications

Chitinase 3–like–1 and its receptors in Hermansky-Pudlak syndrome–associated lung disease

(2015) Yang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1

(2015) Stephania Libreros et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of Chitinase 3-like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis

(2014) B. Ma et al.   CANCER RESEARCH

DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections

(2014) Chun-Chi Liu et al.   NUCLEIC ACIDS RESEARCH

Serum YKL-40 Level Is Associated with the Chemotherapy Response and Prognosis of Patients with Small Cell Lung Cancer

(2014) Chun-Hua Xu et al.   PLoS One

Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway

(2013) Ji Hye Kim et al.   BIOCHEMICAL PHARMACOLOGY

Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2

(2013) Chuan Hua He et al.   Cell Reports

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties

(2012) Marianne Schimpl et al.   BIOCHEMICAL JOURNAL

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

(2011) Chun Geun Lee et al.   Annual Review of Physiology

IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer

(2011) Toshio Fujisawa et al.   INTERNATIONAL JOURNAL OF CANCER

Involvement of JNK-AP-1 and ERK-NF-κB signaling in tension-stimulated expression of Type I collagen and MMP-1 in human periodontal ligament fibroblasts

(2011) Sung-Ho Kook et al.   JOURNAL OF APPLIED PHYSIOLOGY

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer

(2011) M Kawada et al.   ONCOGENE

High serum YKL-40 is a poor prognostic marker in patients with advanced non-small cell lung cancer

(2010) In Keun Choi et al.   ACTA ONCOLOGICA

Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer

(2010) Ina Thöm et al.   CANCER

A Novel Role of Interleukin-13 Receptor  2 in Pancreatic Cancer Invasion and Metastasis

(2009) T. Fujisawa et al.   CANCER RESEARCH

Plasma YKL-40: a potential new cancer biomarker?

(2009) Julia S Johansen et al.   Future Oncology

Chitinase 3-Like-1 (CHI3L1): A Putative Disease Marker at the Interface of Proteomics and Glycomics

(2008) Frederick D. Coffman   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES