Compendium of human transcription factor effector domains

Predicting protein condensate formation using machine learning

(2021) Guido van Mierlo et al.   Cell Reports

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

(2021) Adrian L Sanborn et al.   eLife

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Pan-cancer analysis of whole genomes

(2020)   NATURE

Protein assembly systems in natural and synthetic biology

(2020) Giulio Chiesa et al.   BMC BIOLOGY

A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning

(2020) Ariel Erijman et al.   MOLECULAR CELL

A reference map of the human binary protein interactome

(2020) Katja Luck et al.   NATURE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Targeting post-translational modification of transcription factors as cancer therapy

(2020) Meijia Qian et al.   DRUG DISCOVERY TODAY

Global translation during early development depends on the essential transcription factor PRDM10

(2020) Brenda Y. Han et al.   Nature Communications

Single-gene imaging links genome topology, promoter–enhancer communication and transcription control

(2020) Jieru Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic and chemical interactions

(2020) Rose Oughtred et al.   PROTEIN SCIENCE

High-Throughput Discovery and Characterization of Human Transcriptional Effectors

(2020) Josh Tycko et al.   CELL

Similarity regression predicts evolution of transcription factor sequence specificity

(2019) Samuel A. Lambert et al.   NATURE GENETICS

Enhancer Features that Drive Formation of Transcriptional Condensates

(2019) Krishna Shrinivas et al.   MOLECULAR CELL

50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms

(2019) Robert G. Roeder   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ClinVar: improvements to accessing data

(2019) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia

(2018) Yali Xu et al.   CANCER CELL

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

A high‐throughput method to identify trans‐activation domains within transcription factor sequences

(2018) Cosmas D Arnold et al.   EMBO JOURNAL

High‐throughput discovery of functional disordered regions: investigation of transactivation domains

(2018) Charles NJ Ravarani et al.   Molecular Systems Biology

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain

(2018) Max V. Staller et al.   Cell Systems

Global landscape of mouse and human cytokine transcriptional regulation

(2018) Sebastian Carrasco Pro et al.   NUCLEIC ACIDS RESEARCH

AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors

(2018) Hui Hu et al.   NUCLEIC ACIDS RESEARCH

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

15 years of PhosphoSitePlus®: integrating post-translationally modified sites, disease variants and isoforms

(2018) Peter V Hornbeck et al.   NUCLEIC ACIDS RESEARCH

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

(2016) H. Jane Dyson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survey of variation in human transcription factors reveals prevalent DNA binding changes

(2016) L. A. Barrera et al.   SCIENCE

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

(2015) Nidhi Sahni et al.   CELL

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

(2014) Avinashnarayan Venkatanarayan et al.   NATURE

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

(2014) L. Warfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of transcription factor activity by interconnected post-translational modifications

(2014) Theresa M. Filtz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The eukaryotic linear motif resource ELM: 10 years and counting

(2013) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

(2012) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A census of human transcription factors: function, expression and evolution

(2009) Juan M. Vaquerizas et al.   NATURE REVIEWS GENETICS

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

(2008) Weijun Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY