AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway

Geranylgeranyl pyrophosphate amplifies T reg differentiation via increased IL‐2 expression to ameliorate DSS‐induced colitis

(2021) Mahesh Pandit et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1

(2021) Mahesh Pandit et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Current issues and perspectives in PD-1 blockade cancer immunotherapy

(2020) Kenji Chamoto et al.   International Journal of Clinical Oncology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Mevalonate promotes differentiation of regulatory T cells

(2019) Suman Acharya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

(2019) Maheshwor Timilshina et al.   Cell Reports

Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges

(2019) Ilenia Pacella et al.   Frontiers in Immunology

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

Effects of tumor metabolic microenvironment on regulatory T cells

(2018) Yi-an Wang et al.   Molecular Cancer

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

(2017) Kai Yang et al.   NATURE

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses

(2016) Alison Taylor et al.   IMMUNITY

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial

(2016) F Stephen Hodi et al.   LANCET ONCOLOGY

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review)

(2015) YU-FENG XIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death

(2015) Enyu Rao et al.   Oncotarget

CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic

(2015) Margaret K. Callahan et al.   Frontiers in Oncology

PD-1+ CD8+ T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients

(2014) X Wu et al.   BRITISH JOURNAL OF CANCER

The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function

(2014) Robert J. Johnston et al.   CANCER CELL

Induced regulatory T cells in inhibitory microenvironments created by cancer

(2014) Theresa L Whiteside   EXPERT OPINION ON BIOLOGICAL THERAPY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer

(2014) R. A. Sierra et al.   Cancer Immunology Research

Metabolic Regulation of Regulatory T Cell Development and Function

(2014) David John Coe et al.   Frontiers in Immunology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Current status of interleukin-10 and regulatory T-cells in cancer

(2013) Kristen L. Dennis et al.   CURRENT OPINION IN ONCOLOGY

p38 Mitogen-activated Protein Kinase (MAPK) Promotes Cholesterol Ester Accumulation in Macrophages through Inhibition of Macroautophagy

(2012) Shuang Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells

(2009) J Zhou et al.   ONCOGENE

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

p38 mitogen-activated protein kinase regulates canonical Wnt- -catenin signaling by inactivation of GSK3 

(2008) R. K. Bikkavilli et al.   JOURNAL OF CELL SCIENCE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE