Article
Cell Biology
Xin-xin Xiang, Yong-liang Liu, Yi-fan Kang, Xiang Lu, Kai Xu
Summary: Mex-3 RNA Binding Family Member A (MEX3A) is significantly upregulated in nasopharyngeal carcinoma (NPC) and negatively associated with prognosis. Depletion of MEX3A inhibits cell proliferation, invasion, and migration while increasing apoptosis in NPC cells. MEX3A may promote NPC development and progression through the miR-3163/SCIN axis by regulating NF-kappa B signaling.
CELL DEATH & DISEASE
(2022)
Article
Pathology
Xing Fang, Wei Huang, Ping Wu, Junfeng Zeng, Xin Li
Summary: The study revealed that circTRAF3 plays a crucial role in metastasis and survival of NPC patients by adsorbing miR-203a-3p to eliminate its inhibitory effect on AKT3, thus acting as an oncogene in NPC. This finding provides a new therapeutic target for metastatic NPC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Cell Biology
Yajie Zhao, Chao Li, Yan Zhang, Zhanzhan Li
Summary: CircTMTC1 is highly expressed and miR-495 is downregulated in nasopharyngeal carcinoma (NPC), which are associated with poor prognosis. CircTMTC1 promotes NPC progression through targeting miR-495 and activating the MET-eIF4G1 translational regulation axis.
CELL DEATH & DISEASE
(2022)
Article
Nanoscience & Nanotechnology
Kaimei Fan, Huicheng Zhu, Lingqiang Qi, Yingliang Huang, Xiaoping Xia, Kai Wu
Summary: This study investigated the effects of miR-137 on the biological cell function of nasopharyngeal carcinoma (NPC) cells. Clinical samples and cell lines were used to detect the expression level of miR-137 and identify TWIST1 as a target. Up-regulation of miR-137 resulted in decreased TWIST1 expression and inhibited cell functions such as proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT). The findings suggest that miR-137 could be a potential therapeutic target for NPC.
SCIENCE OF ADVANCED MATERIALS
(2023)
Article
Oncology
Gang Wang, Fangzheng Zhou, Tong Ou, Haiyan Sun, Zhirui Shan, Yingshen Lu, Gui Chen, Simin Yuan, Xiaowen Zhang, Song Wu
Summary: The dysregulation of miR-182-5p has been identified as potential diagnostic and prognostic biomarkers for some cancers, however, its role in nasopharyngeal carcinoma (NPC) had not been explored. Our study demonstrated that up-regulation of miR-182-5p in NPC is associated with tumor development and poor prognosis, and it facilitates cell proliferation and migration by down-regulating ZFP36L1 expression through a HIF-1 alpha/miR-182-5p/ZFP36L1 axis, suggesting a novel therapeutic target for NPC management.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.
Article
Biochemistry & Molecular Biology
Lixiao Xie, Kaiwen Zhang, Bo You, Haimeng Yin, Panpan Zhang, Ying Shan, Zhifeng Gu, Qicheng Zhang
Summary: In nasopharyngeal carcinoma, exosomes released by cells with high levels of miR-455 enhance vascular permeability and promote metastasis by targeting ZO-1, and this process is associated with HIF-1α. The HIF-1α-miR-455-ZO-1 signaling pathway may serve as a potential predictor and therapeutic target for metastatic nasopharyngeal carcinoma.
MOLECULAR CARCINOGENESIS
(2023)
Article
Cell Biology
Chun Cheng, Jun Yang, Si-Wei Li, Guofu Huang, Chenxi Li, Wei-Ping Min, Yi Sang
Summary: Histone deacetylases (HDACs) are involved in tumor progression, with HDAC4 playing a crucial role in promoting cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC). High expression of HDAC4 in NPC tissues is associated with poor overall survival and progression-free survival. Inhibition of HDAC4 may present a potential therapeutic strategy for NPC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Dong-Hua Luo, Jia-Xin Li, Wan-Ping Guo, Chen-Guang Guo, Xiao-Han Meng, Pei-Jun Xie, Jie-Yi Lin, Hao-Yuan Mo, Qun Zhang, Yong Chen, Guo-Ping Shen
Summary: This study compared the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC). The thoracic vertebra was the most common site of metastasis, and patients with SBM were more likely to have metastasis to the cervical vertebra. Patients with SBM had better overall survival. Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. Attention should be paid to bone metastases during the first 2 years following NPC diagnosis.
Article
Cell Biology
Xinping Chen, Weihua Xu, Zhichao Ma, Juan Zhu, Junjie Hu, Xiaojuan Li, Shengmiao Fu
Summary: This study revealed that circ_0000215 is overexpressed in NPC and exerts oncogenic effects by regulating the miR-512-5p/PIK3R1 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Rentao Hou, Xiong Liu, Huiling Yang, Shuting Deng, Chao Cheng, Jiahao Liu, Yonghao Li, Yewei Zhang, Jingwen Jiang, Zhibo Zhu, Yun Su, Liyang Wu, Yingying Xie, Xiaoning Li, Wenmin Li, Zhen Liu, Weiyi Fang
Summary: In this study, cinobufagin (CB) was found to inhibit metastasis in nasopharyngeal carcinoma (NPC), and its therapeutic effect was enhanced when combined with cisplatin (DDP). CB induced the expression of ENKUR by deregulating the PI3K/AKT pathway and suppressing c-Jun, leading to the inhibition of NPC metastasis. ENKUR acted as a tumor suppressor by reducing MYH9 expression and preventing p53 ubiquitination degradation, thus suppressing epithelial-mesenchymal transition (EMT).
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Oncology
Xiaotao Geng, Furong Hao, Guiyan Han, Yaping Zhang, Peiyan Qin
Summary: Nasopharyngeal carcinoma rarely metastasizes to the dura and multiple locations in the brain, presenting challenges in diagnosis and treatment that may require a combination of therapy modalities such as radiotherapy and chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huali Ma, Yinyi Qiu, Haojiang Li, Fei Xie, Guangying Ruan, Lizhi Liu, Chunyan Cui, Annan Dong
Summary: Nodal matting was found to be an independent prognostic factor for distant metastasis-free survival in NPC patients, with potential to identify high-risk patients. The nomogram including nodal matting showed higher predictive accuracy compared to the nomogram without it.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia
Summary: The optimal treatment strategy for de novo metastatic nasopharyngeal carcinoma (mNPC) is a combination of palliative chemotherapy (PCT) followed by concurrent chemoradiotherapy. Specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested to achieve better survival outcomes.
CANCER CELL INTERNATIONAL
(2022)