Axonal spheroids in neurodegeneration

Microglia provide structural resolution to injured dendrites after severe seizures

(2021) Ukpong B. Eyo et al.   Cell Reports

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

(2020) A. Negrete-Hurtado et al.   Nature Communications

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

(2020) Brian M. Woolums et al.   Nature Communications

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

(2020) Nicole Scott‐Hewitt et al.   EMBO JOURNAL

SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

(2020) Kwang Woo Ko et al.   JOURNAL OF CELL BIOLOGY

Beading of injured axons driven by tension- and adhesion-regulated membrane shape instability

(2020) Xueying Shao et al.   Journal of the Royal Society Interface

Regulation of degenerative spheroids after injury

(2020) Yu Yong et al.   Scientific Reports

Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis

(2019) Maarten E. Witte et al.   NEURON

Axonal degeneration is mediated by necroptosis activation

(2019) Macarena S. Arrázola et al.   JOURNAL OF NEUROSCIENCE

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM

(2019) Michael Carty et al.   IMMUNITY

Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration

(2019) Guiping Wang et al.   eLife

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration

(2019) Adrien Vaquié et al.   Cell Reports

Axonal transport and neurological disease

(2019) James N. Sleigh et al.   Nature Reviews Neurology

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

(2019) Inbar Shlomovitz et al.   Cell Communication and Signaling

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

(2019) Taide Wang et al.   CELL DEATH AND DIFFERENTIATION

p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture

(2019) Yu Yong et al.   JOURNAL OF NEUROSCIENCE

Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons

(2019) Vidur Sabharwal et al.   Frontiers in Cellular Neuroscience

Fiery Cell Death: Pyroptosis in the Central Nervous System

(2019) Brienne A. McKenzie et al.   TRENDS IN NEUROSCIENCES

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration

(2018) Nicolas Unsain et al.   Scientific Reports

The Axon-Myelin Unit in Development and Degenerative Disease

(2018) Ruth M. Stassart et al.   Frontiers in Neuroscience

AARS2 Compound Heterozygous Variants in a Case of Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

(2018) Danqing Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phosphatidylserine Externalization Results from and Causes Neurite Degeneration in Drosophila

(2018) Maria L. Sapar et al.   Cell Reports

The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling

(2018) Ana Rita Costa et al.   Frontiers in Molecular Neuroscience

Crashing the computer: apoptosis vs. necroptosis in neuroinflammation

(2018) Bradlee L. Heckmann et al.   CELL DEATH AND DIFFERENTIATION

Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration

(2018) Vered Shacham-Silverberg et al.   Cell Death & Disease

Polarity of varicosity initiation in central neuron mechanosensation

(2017) Yuanzheng Gu et al.   JOURNAL OF CELL BIOLOGY

Axonal Degeneration in Retinal Ganglion Cells Is Associated with a Membrane Polarity-Sensitive Redox Process

(2017) Mohammadali Almasieh et al.   JOURNAL OF NEUROSCIENCE

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

Phosphatidylserine save-me signals drive functional recovery of severed axons inCaenorhabditis elegans

(2017) Zehra C. Abay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contacts between the endoplasmic reticulum and other membranes in neurons

(2017) Yumei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

(2017) Alejandra Catenaccio et al.   Cell Death & Disease

Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium

(2017) Uris Ros et al.   Cell Reports

Electron microscopy of myelin: Structure preservation by high-pressure freezing

(2016) Wiebke Möbius et al.   BRAIN RESEARCH

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter

(2016) Sérgio Carvalho Leite et al.   Cell Reports

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?

(2015) Natalia Sánchez de Groot et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

Pathologic Staging of White Matter Lesions in Adult-Onset Leukoencephalopathy/Leukodystrophy With Axonal Spheroids

(2015) Murad Alturkustani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Diverse cellular and molecular modes of axon degeneration

(2014) Lukas J. Neukomm et al.   TRENDS IN CELL BIOLOGY

Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration

(2014) Trisha R. Stankiewicz et al.   Frontiers in Cellular Neuroscience

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury

(2013) Nicole Forgione et al.   World Neurosurgery

Axon Degeneration: Where the Wlds Things Are

(2012) Jack T. Wang et al.   CURRENT BIOLOGY

Axonal pathology in traumatic brain injury

(2012) Victoria E. Johnson et al.   EXPERIMENTAL NEUROLOGY

Axon degeneration: Molecular mechanisms of a self-destruction pathway

(2012) Jack T. Wang et al.   JOURNAL OF CELL BIOLOGY

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Focal Increases of Axoplasmic Ca2+, Aggregation of Sodium-Calcium Exchanger, N-type Ca2+ Channel, and Actin Define the Sites of Spheroids in Axons Undergoing Oxidative Stress

(2012) A. G. Barsukova et al.   JOURNAL OF NEUROSCIENCE

In Vivo Nerve-Macrophage Interactions Following Peripheral Nerve Injury

(2012) A. F. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury

(2011) Min D. Tang-Schomer et al.   EXPERIMENTAL NEUROLOGY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

(2011) S. A. Barrientos et al.   JOURNAL OF NEUROSCIENCE

The Role of the Cytoskeleton in Volume Regulation and Beading Transitions in PC12 Neurites

(2010) Pablo Fernández et al.   BIOPHYSICAL JOURNAL

Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites

(2010) Lukas C. Kapitein et al.   CURRENT BIOLOGY

Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration

(2010) Bogdan Beirowski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke

(2010) M. D. Budde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation

(2010) David P. Stirling et al.   TRENDS IN MOLECULAR MEDICINE

Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration

(2009) N. Yahata et al.   JOURNAL OF NEUROSCIENCE

Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage

(2008) Devrim Kilinc et al.   EXPERIMENTAL NEUROLOGY

Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A2 Deficiency in Mice: A Model of Human Neurodegenerative Disease

(2008) K. Shinzawa et al.   JOURNAL OF NEUROSCIENCE