Nanoscale materials-based hybrid frameworks modified electrochemical biosensors for early cancer diagnostics: An overview of current trends and challenges

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Development of g-C3N4/Cu-DTO MOF nanocomposite based electrochemical sensor towards sensitive determination of an endocrine disruptor BPSIP

(2021) Ankit Kumar Singh et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples

(2020) Pegah Mahmoodi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Biomarkers for the Early Detection of Hepatocellular Carcinoma

(2020) Neehar D Parikh et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A novel electrochemical immunosensor for carcinoembryonic antigen based on Cu-MOFs-TB/polydopamine nanocarrier

(2020) Jianbo Liu et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

(2020) Veronika Gajdosova et al.   SENSORS

Label-Free Monitoring of Histone Acetylation Using Aptamer-Functionalized Field-Effect Transistor and Quartz Crystal Microbalance Sensors

(2020) Tatsuro Goda et al.   Micromachines

Magnetic nanomaterial-based electrochemical biosensors for the detection of diverse circulating cancer biomarkers

(2020) Kevin M. Koo et al.   Current Opinion in Electrochemistry

Sn-MOF@CNT nanocomposite: An efficient electrochemical sensor for detection of hydrogen peroxide

(2020) Sushma Rani et al.   ENVIRONMENTAL RESEARCH

A novel electrochemical immunosensor based on acetylene black/epoxy-substituted-polypyrrole polymer composite for the highly sensitive and selective detection of interleukin 6

(2020) Elif Burcu Aydın et al.   TALANTA

Aptamer-functionalized metal-organic frameworks (MOFs) for biosensing

(2020) Mengzhen Lv et al.   BIOSENSORS & BIOELECTRONICS

An electrochemical biosensor for prostate cancer biomarker detection using graphene oxide-gold nanostructures

(2019) Zahra Akbari jonous et al.   ENGINEERING IN LIFE SCIENCES

Effective Distance for DNA-Mediated Charge Transport between Repair Proteins

(2019) Edmund C. M. Tse et al.   ACS Central Science

Spheroid-3D and Monolayer-2D Intestinal Electrochemical Biosensor for Toxicity/Viability Testing: Applications in Drug Screening, Food Safety, and Environmental Pollutant Analysis

(2019) Evangelia Flampouri et al.   ACS Sensors

Generic Neutravidin Biosensor for Simultaneous Multiplex Detection of MicroRNAs via Electrochemically Encoded Responsive Nanolabels

(2019) Sawsen Azzouzi et al.   ACS Sensors

Ultrasensitive Immunosensor Array for TNF-α Detection in Artificial Saliva using Polymer-Coated Magnetic Microparticles onto Screen-Printed Gold Electrode

(2019) Lassaad Barhoumi et al.   SENSORS

Phytic acid@Ag-based all-solid-state ion selective electrode for potentiometric detection of Cu2+

(2019) Zhenzhen Wang et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review

(2019) Gabriele Cervino et al.   DISEASE MARKERS

Fabrication of an ultrasensitive and selective electrochemical aptasensor to detect carcinoembryonic antigen by using a new nanocomposite

(2019) Mohammad Mazloum- Ardakani et al.   BIOSENSORS & BIOELECTRONICS

Avoiding Pre-Isolation Step in Exosome Analysis: Direct Isolation and Sensitive Detection of Exosomes Using Gold-Loaded Nanoporous Ferric Oxide Nanozymes

(2019) Kseniia Boriachek et al.   ANALYTICAL CHEMISTRY

Progress in research on gold nanoparticles in cancer management

(2019) Jingwen Peng et al.   MEDICINE

Colorimetric immunosensor for determination of prostate specific antigen using surface plasmon resonance band of colloidal triangular shape gold nanoparticles

(2019) Pari Karami et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Application of metal-organic framework as redox probe in an electrochemical aptasensor for sensitive detection of MUC1

(2019) Zahra Hatami et al.   BIOSENSORS & BIOELECTRONICS

A novel zinc finger protein–based amperometric biosensor for miRNA determination

(2019) Eloy Povedano et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Electrochemical nano-genosensor for highly sensitive detection of miR-21 biomarker based on SWCNT-grafted dendritic Au nanostructure for early detection of prostate cancer

(2019) Abbas Sabahi et al.   TALANTA

Non-invasive oral cancer detection from saliva using zinc oxide–reduced graphene oxide nanocomposite based bioelectrode

(2019) Shilpi Verma et al.   MRS Communications

Highly Stable Mesoporous Luminescence-Functionalized MOF with Excellent Electrochemiluminescence Property for Ultrasensitive Immunosensor Construction

(2018) Gui-Bing Hu et al.   ACS Applied Materials & Interfaces

An amplification-free electrochemical detection of exosomal miRNA-21 in serum samples

(2018) Kseniia Boriachek et al.   ANALYST

Detection of prostate specific antigen (PSA) in human saliva using an ultra-sensitive nanocomposite of graphene nanoplatelets with diblock-co-polymers and Au electrodes

(2018) M. S. Khan et al.   ANALYST

Label-free electrochemical immunoassay for neuron specific enolase based on 3D macroporous reduced graphene oxide/polyaniline film

(2018) Qi Zhang et al.   ANALYTICAL BIOCHEMISTRY

Sensing platform for neuron specific enolase based on molecularly imprinted polymerized ionic liquids in between gold nanoarrays

(2018) Xing Wang et al.   BIOSENSORS & BIOELECTRONICS

A novel cytosensor based on Pt@Ag nanoflowers and AuNPs/Acetylene black for ultrasensitive and highly specific detection of Circulating Tumor Cells

(2018) Sitian Tang et al.   BIOSENSORS & BIOELECTRONICS

CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening

(2018) Shaowei Ding et al.   BIOSENSORS & BIOELECTRONICS

A highly selective electrochemical immunosensor based on conductive carbon black and star PGMA polymer composite material for IL-8 biomarker detection in human serum and saliva

(2018) Muhammet Aydın et al.   BIOSENSORS & BIOELECTRONICS

Target-triggered signal-on ratiometric electrochemiluminescence sensing of PSA based on MOF/Au/G-quadruplex

(2018) Kang Shao et al.   BIOSENSORS & BIOELECTRONICS

OMIP-045: Characterizing human head and neck tumors and cancer cell lines with mass cytometry

(2018) Tess M. Brodie et al.   CYTOMETRY PART A

Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection

(2018) Sunil Arya et al.   SENSORS

Biominerized gold-Hemin@MOF composites with peroxidase-like and gold catalysis activities: A high-throughput colorimetric immunoassay for alpha-fetoprotein in blood by ELISA and gold-catalytic silver staining

(2018) Liyan Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Ultrasensitive electrochemical paper-based biosensor for microRNA via strand displacement reaction and metal-organic frameworks

(2018) He Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Sandwich-type electrochemical immunosensor for CEA detection based on Ag/MoS 2 @Fe 3 O 4 and an analogous ELISA method with total internal reflection microscopy

(2018) Yaoguang Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A sensitive label-free electrochemical immunosensor for detection of cytokeratin 19 fragment antigen 21-1 based on 3D graphene with gold nanopaticle modified electrode

(2018) Yan Zeng et al.   TALANTA

Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene

(2018) Razieh Salahandish et al.   BIOSENSORS & BIOELECTRONICS

A highly sensitive and reliable detection of CA15-3 in patient plasma with electrochemical biosensor labeled with magnetic beads

(2018) Sattar Akbari Nakhjavani et al.   BIOSENSORS & BIOELECTRONICS

N-(aminobutyl)-N-(ethylisoluminol) functionalized Fe-based metal-organic frameworks with intrinsic mimic peroxidase activity for sensitive electrochemiluminescence mucin1 determination

(2018) Zili Wang et al.   BIOSENSORS & BIOELECTRONICS

Two-dimensional oriented growth of Zn-MOF-on-Zr-MOF architecture: A highly sensitive and selective platform for detecting cancer markers

(2018) Nan Zhou et al.   BIOSENSORS & BIOELECTRONICS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Aerogels prepared from polymeric β-cyclodextrin and graphene aerogels as a novel host-guest system for immobilization of antibodies: a voltammetric immunosensor for the tumor marker CA 15–3

(2018) Haiyan Jia et al.   MICROCHIMICA ACTA

Electrochemical immunosensor for the breast cancer marker CA 15–3 based on the catalytic activity of a CuS/reduced graphene oxide nanocomposite towards the electrooxidation of catechol

(2017) Jafar Amani et al.   MICROCHIMICA ACTA

Electrochemical Detecting Lung Cancer-Associated Antigen Based on Graphene-Gold Nanocomposite

(2017) Zheng Wei et al.   MOLECULES

Carbon Nanomaterial Based Biosensors for Non-Invasive Detection of Cancer and Disease Biomarkers for Clinical Diagnosis

(2017) Tibor Pasinszki et al.   SENSORS

Multifunctional substrate of label-free electrochemical immunosensor for ultrasensitive detection of cytokeratins antigen 21-1

(2017) Huiqiang Wang et al.   Scientific Reports

Cascade Signal Amplification Based on Copper Nanoparticle-Reported Rolling Circle Amplification for Ultrasensitive Electrochemical Detection of the Prostate Cancer Biomarker

(2016) Ye Zhu et al.   ACS Applied Materials & Interfaces

Sensitive detection and glycoprofiling of a prostate specific antigen using impedimetric assays

(2016) D. Pihíková et al.   ANALYST

Electrochemical sensors for the simultaneous determination of zinc, cadmium and lead using a Nafion/ionic liquid/graphene composite modified screen-printed carbon electrode

(2016) Sudkate Chaiyo et al.   ANALYTICA CHIMICA ACTA

Amplification-Free Detection of Gene Fusions in Prostate Cancer Urinary Samples Using mRNA–Gold Affinity Interactions

(2016) Kevin M. Koo et al.   ANALYTICAL CHEMISTRY

Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(III) complex as catalyst

(2016) Xiangmin Miao et al.   BIOSENSORS & BIOELECTRONICS

An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer

(2016) Mostafa Azimzadeh et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive electrochemical sensing platform for microRNA based on tungsten oxide-graphene composites coupling with catalyzed hairpin assembly target recycling and enzyme signal amplification

(2016) Hong-Lei Shuai et al.   BIOSENSORS & BIOELECTRONICS

Recent Advances of Carbon Nanotubes-based Electrochemical Immunosensors for the Detection of Protein Cancer Biomarkers

(2016) Taotao Feng et al.   ELECTROANALYSIS

CD 59 Targeted Ultrasensitive Electrochemical Immunosensor for Fast and Noninvasive Diagnosis of Oral Cancer

(2016) Meenakshi Choudhary et al.   ELECTROANALYSIS

Nano interfaced biosensor for detection of choline in triple negative breast cancer cells

(2016) Vignesh Thiagarajan et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Characterization of the DNA-Mediated Oxidation of Dps, A Bacterial Ferritin

(2016) Anna R. Arnold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances

(2016) Richard A. Revia et al.   Materials Today

Enhanced amperometric immunoassay for the prostate specific antigen using Pt-Cu hierarchical trigonal bipyramid nanoframes as a label

(2016) Lei Jiao et al.   MICROCHIMICA ACTA

Label-Free Ultrasensitive Memristive Aptasensor

(2016) Ioulia Tzouvadaki et al.   NANO LETTERS

A ZnO–CNT nanocomposite based electrochemical DNA biosensor for meningitis detection

(2016) Manvi Tak et al.   RSC Advances

Clinical Application of High-intensity Focused Ultrasound in Cancer Therapy

(2016) Yi-Hsuan Hsiao et al.   Journal of Cancer

The diagnostic value of serum CEA, NSE and MMP-9 for on-small cell lung cancer

(2016) Liu Xu et al.   Open Medicine

Single-walled carbon nanotube based transparent immunosensor for detection of a prostate cancer biomarker osteopontin

(2015) Abhinav Sharma et al.   ANALYTICA CHIMICA ACTA

A novel antibody–antigen based impedimetric immunosensor for low level detection of HER2 in serum samples of breast cancer patients via modification of a gold nanoparticles decorated multiwall carbon nanotube-ionic liquid electrode

(2015) Elham Arkan et al.   ANALYTICA CHIMICA ACTA

Ultraselective Homogeneous Electrochemical Biosensor for DNA Species Related to Oral Cancer Based on Nicking Endonuclease Assisted Target Recycling Amplification

(2015) Yue Tan et al.   ANALYTICAL CHEMISTRY

Ultrasensitive electrochemical immunosensor for PSA biomarker detection in prostate cancer cells using gold nanoparticles/PAMAM dendrimer loaded with enzyme linked aptamer as integrated triple signal amplification strategy

(2015) Begard Kavosi et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical aptamer/antibody based sandwich immunosensor for the detection of EGFR, a cancer biomarker, using gold nanoparticles as a signaling probe

(2015) Hoda Ilkhani et al.   BIOSENSORS & BIOELECTRONICS

A novel controlled release system-based homogeneous immunoassay protocol for SCCA using magnetic mesoporous Fe3O4 as a nanocontainer and aminated polystyrene microspheres as a molecular gate

(2015) Jian Gao et al.   BIOSENSORS & BIOELECTRONICS

Low fouling label-free DNA sensor based on polyethylene glycols decorated with gold nanoparticles for the detection of breast cancer biomarkers

(2015) Wenting Wang et al.   BIOSENSORS & BIOELECTRONICS

PVC-Membrane Potentiometric Sensor for the Determination of Tamoxifen in Pharmaceutical Formulations

(2015) Gulsah Saydan Kanberoglu et al.   IEEE SENSORS JOURNAL

A highly sensitive and selective electrochemical DNA biosensor to diagnose breast cancer

(2015) A. Benvidi et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Label-free capacitance based aptasensor platform for the detection of HER2/ErbB2 cancer biomarker in serum

(2015) Anjum Qureshi et al.   SENSORS AND ACTUATORS B-CHEMICAL

An ultrasensitive electrochemical immunosensor based on the catalytical activity of MoS2-Au composite using Ag nanospheres as labels

(2015) Xiu Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Au-F127 strawberry-like nanospheres as an electrochemical interface for sensitive detection of carcinoembryonic antigen in real sample

(2015) Juan Li et al.   TALANTA

Sandwich-type electrochemical immunosensor using dumbbell-like nanoparticles for the determination of gastric cancer biomarker CA72-4

(2015) Dan Wu et al.   TALANTA

Dendritic Pt@Au nanowires as nanocarriers and signal enhancers for sensitive electrochemical detection of carcinoembryonic antigen

(2015) Shuyan Xue et al.   RSC Advances

Graphene oxide/DNA-decorated electrode for the fabrication of microRNA biosensor

(2015) Erlin Sun et al.   RSC Advances

MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors

(2014) Deblina Sarkar et al.   ACS Nano

Duplex Microfluidic SERS Detection of Pathogen Antigens with Nanoyeast Single-Chain Variable Fragments

(2014) Yuling Wang et al.   ANALYTICAL CHEMISTRY

eMethylsorb: electrochemical quantification of DNA methylation at CpG resolution using DNA–gold affinity interactions

(2014) Abu Ali Ibn Sina et al.   CHEMICAL COMMUNICATIONS

Dual signal amplification of horseradish peroxidase functionalized nanocomposite as trace label for the electrochemical detection of carcinoembryonic antigen

(2014) Dexiang Feng et al.   ELECTROCHIMICA ACTA

Tumour tissue sampling for lung cancer management in the era of personalised therapy: what is good enough for molecular testing?

(2014) L. Kim et al.   EUROPEAN RESPIRATORY JOURNAL

Electrochemical immunosensor for the analysis of the breast cancer biomarker HER2 ECD

(2014) Raquel C.B. Marques et al.   TALANTA

Ultrasensitive non-mediator electrochemical immunosensors using Au/Ag/Au core/double shell nanoparticles as enzyme-mimetic labels

(2014) Yulan Wang et al.   TALANTA

Non-invasive wearable electrochemical sensors: a review

(2014) Amay J. Bandodkar et al.   TRENDS IN BIOTECHNOLOGY

Identification of Volatile Biomarkers of Gastric Cancer Cells and Ultrasensitive Electrochemical Detection based on Sensing Interface of Au-Ag Alloy coated MWCNTs

(2014) Yixia Zhang et al.   Theranostics

Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and Management

(2013) Rajal B. Shah   ADVANCES IN ANATOMIC PATHOLOGY

Paper-Based Microfluidic Electrochemical Immunodevice Integrated with Nanobioprobes onto Graphene Film for Ultrasensitive Multiplexed Detection of Cancer Biomarkers

(2013) Yafeng Wu et al.   ANALYTICAL CHEMISTRY

A novel electrically magnetic-controllable electrochemical biosensor for the ultra sensitive and specific detection of attomolar level oral cancer-related microRNA

(2013) ZongWen Wang et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical impedance immunosensor based on gold nanoparticles–protein G for the detection of cancer marker epidermal growth factor receptor in human plasma and brain tissue

(2013) Reda Elshafey et al.   BIOSENSORS & BIOELECTRONICS

Multiplexed Electrochemistry of DNA-Bound Metalloproteins

(2013) Catrina G. Pheeney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carboxylated multiwalled carbon nanotubes based biosensor for aflatoxin detection

(2013) Chandan Singh et al.   SENSORS AND ACTUATORS B-CHEMICAL

Ultrasensitive electrochemical detection of cancer associated biomarker HER3 based on anti-HER3 biosensor

(2013) Münteha Nur Sonuç et al.   TALANTA

Non-invasive in vivo assessment of IDH1 mutational status in glioma

(2013) Myriam M. Chaumeil et al.   Nature Communications

Ultrasensitive electrochemiluminescence immunosensor using PtAg@carbon nanocrystals composites as labels and carbon nanotubes-chitosan/gold nanoparticles as enhancer

(2012) Meng Zhang et al.   ANALYST

Sensitive sandwich ELISA based on a gold nanoparticle layer for cancer detection

(2012) Feng Zhou et al.   ANALYST

Sensitive detection of human breast cancer cells based on aptamer–cell–aptamer sandwich architecture

(2012) Xiaoli Zhu et al.   ANALYTICA CHIMICA ACTA

Ultrasensitive and Selective Electrochemical Diagnosis of Breast Cancer Based on a Hydrazine–Au Nanoparticle–Aptamer Bioconjugate

(2012) Ye Zhu et al.   ANALYTICAL CHEMISTRY

Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: Application to the sensitive and specific detection of tumor markers from breast cancer sera

(2012) Zhugen Yang et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical immunosensor with N-doped graphene-modified electrode for label-free detection of the breast cancer biomarker CA 15-3

(2012) He Li et al.   BIOSENSORS & BIOELECTRONICS

Electrochemical Biosensors for Cancer Biomarker Detection

(2012) Jianping Li et al.   ELECTROANALYSIS

Electrochemical immunosensor for prostate-specific antigen using a glassy carbon electrode modified with a nanocomposite containing gold nanoparticles supported with starch-functionalized multi-walled carbon nanotubes

(2012) Jianniao Tian et al.   MICROCHIMICA ACTA

Use of nanohybrid materials as electrochemical transducers for mercury sensors

(2012) Daniel Martín-Yerga et al.   SENSORS AND ACTUATORS B-CHEMICAL

Early Detection Biomarkers for Ovarian Cancer

(2012) Sreeja Sarojini et al.   Journal of Oncology

MRI for breast cancer screening, diagnosis, and treatment

(2011) Monica Morrow et al.   LANCET

Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene?

(2010) Wenrong Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A folding-based electrochemical aptasensor for detection of vascular endothelial growth factor in human whole blood

(2010) Shuang Zhao et al.   BIOSENSORS & BIOELECTRONICS

A disposable electrochemical immunosensor for carcinoembryonic antigen based on nano-Au/multi-walled carbon nanotubes–chitosans nanocomposite film modified glassy carbon electrode

(2009) Ke-Jing Huang et al.   ANALYTICA CHIMICA ACTA

Genomic and proteomic biomarkers for cancer: A multitude of opportunities

(2009) Michael A. Tainsky   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A potentiometric sensor for the determination of diclofenac

(2009) Zh. A. Kormosh et al.   JOURNAL OF ANALYTICAL CHEMISTRY

Detection and differentiation of normal, cancerous, and metastatic cells using nanoparticle-polymer sensor arrays

(2009) A. Bajaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers in lung cancer: from early detection to novel therapeutics and decision making

(2008) April Scott et al.   Biomarkers in Medicine

Electrochemical Sensors Based on Organic Conjugated Polymers

(2008) Md. Rahman et al.   SENSORS