Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk

Treatments for NAFLD: State of Art

(2021) Alessandro Mantovani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk

(2021) Emir Muzurović et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK against NASH

(2020) Paulina Strzyz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

(2020) Peng Zhao et al.   SCIENCE

Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2020) Qing Ye et al.   Lancet Gastroenterology & Hepatology

Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr −/− .Leiden mice

(2020) Anouk C. Tengeler et al.   FASEB JOURNAL

Commentary: From mice to men: In search for dietary interventions to form the background on which pharmacotherapy for non-alcoholic fatty liver disease should be based

(2020) Emir Muzurović et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Translational Mouse Model for NASH with Advanced Fibrosis and Atherosclerosis Expressing Key Pathways of Human Pathology

(2020) Anita M. van den Hoek et al.   Cells

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

(2020) Xiaoyan Li et al.   Cell and Bioscience

Harnessing Muscle–Liver Crosstalk to Treat Nonalcoholic Steatohepatitis

(2020) Manu V. Chakravarthy et al.   Frontiers in Endocrinology

Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice

(2019) Kanita Salic et al.   PLoS One

Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis

(2019) Kanita Salic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex-Specific Differences in Fat Storage, Development of Non-Alcoholic Fatty Liver Disease and Brain Structure in Juvenile HFD-Induced Obese Ldlr-/-.Leiden Mice

(2019) Sophie A.H. Jacobs et al.   Nutrients

Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation and fibrosis

(2018) Simon Hohenester et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Extra-Virgin Olive Oil with Natural Phenolic Content Exerts an Anti-Inflammatory Effect in Adipose Tissue and Attenuates the Severity of Atherosclerotic Lesions in Ldlr −/−.Leiden Mice

(2018) Amparo Luque-Sierra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study

(2018) Martine C. Morrison et al.   Frontiers in Physiology

Diet-Independent Correlations between Bacteria and Dysfunction of Gut, Adipose Tissue, and Liver: A Comprehensive Microbiota Analysis in Feces and Mucosa of the Ileum and Colon in Obese Mice with NAFLD

(2018) Eveline Gart et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

(2018) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sarcopenia in hiding: The risk and consequence of underestimating muscle dysfunction in nonalcoholic steatohepatitis

(2017) Rahima A. Bhanji et al.   HEPATOLOGY

Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice

(2017) I A C Arnoldussen et al.   INTERNATIONAL JOURNAL OF OBESITY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice

(2017) Charlotte Pelgrim et al.   Nutrients

AMPK: a novel target for treating hepatic fibrosis

(2017) Zhenxing Liang et al.   Oncotarget

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis

(2017) Petra Mulder et al.   PLoS One

A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice

(2017) Marieke H. Schoemaker et al.   PLoS One

Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease

(2016) William N. Hannah et al.   DIGESTIVE DISEASES AND SCIENCES

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice

(2016) M C Morrison et al.   INTERNATIONAL JOURNAL OF OBESITY

Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease

(2016) Josep M. Argilés et al.   Journal of the American Medical Directors Association

Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes

(2015) Wen Liang et al.   BRITISH JOURNAL OF PHARMACOLOGY

A low-fat high-carbohydrate diet reduces plasma total adiponectin concentrations compared to a moderate-fat diet with no impact on biomarkers of systemic inflammation in a randomized controlled feeding study

(2015) Xiaoling Song et al.   EUROPEAN JOURNAL OF NUTRITION

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity

(2015) P Mulder et al.   INTERNATIONAL JOURNAL OF OBESITY

TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice

(2015) Shiming Jiang et al.   JOURNAL OF HEPATOLOGY

Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

(2014) S. Kuhnast et al.   EUROPEAN HEART JOURNAL

Metabolically induced liver inflammation leads to NASH and differs from LPS- or IL-1β-induced chronic inflammation

(2014) Wen Liang et al.   LABORATORY INVESTIGATION

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

Severity of non-alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle

(2013) Yoichiro Kitajima et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Role of PGC-1α signaling in skeletal muscle health and disease

(2012) Chounghun Kang et al.   Annals of the New York Academy of Sciences

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections

(2012) Miguel Galarraga et al.   JOURNAL OF LIPID RESEARCH

CCAAT/Enhancer Binding Protein Beta is Expressed in Satellite Cells and Controls Myogenesis

(2012) François Marchildon et al.   STEM CELLS

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

The obese healthy paradox: is inflammation the answer?

(2010) Nuria Barbarroja et al.   BIOCHEMICAL JOURNAL

The effects of apelin treatment on skeletal muscle mitochondrial content

(2009) Bruce C. Frier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

(2009) Kittichai Promrat et al.   HEPATOLOGY

Nonlinear optical microscopy: use of second harmonic generation and two-photon microscopy for automated quantitative liver fibrosis studies

(2008) Wanxin Sun et al.   JOURNAL OF BIOMEDICAL OPTICS