Angiopoietin-like protein 8 (betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice

Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management

(2021) Troels S Jensen et al.   BRAIN

Mebhydrolin ameliorates glucose homeostasis in type 2 diabetic mice by functioning as a selective FXR antagonist

(2021) Tong Zhao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of basal expression of hepatic PEPCK and G6Pase by AKT2

(2020) Lina He et al.   BIOCHEMICAL JOURNAL

Regulation of ANGPTL8 in liver and adipose tissue by nutritional and hormonal signals and its effect on glucose homeostasis in mice

(2020) Lu Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

ANGPTL8 enhances insulin sensitivity by directly activating insulin-mediated AKT phosphorylation

(2020) Zongli Zhang et al.   GENE

Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids

(2020) Yan Q. Chen et al.   JOURNAL OF LIPID RESEARCH

Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research

(2020) Paul W. Franks et al.   DIABETOLOGIA

Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia

(2019) Anfang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

ANGPTL8 regulates adipocytes differentiation and adipogenesis in bovine

(2019) Xuefeng Wei et al.   GENE

PPP1R3C mediates metformin-inhibited hepatic gluconeogenesis

(2019) Xueying Ji et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Trends in incidence of total or type 2 diabetes: systematic review

(2019) Dianna J Magliano et al.   BMJ-British Medical Journal

Angptl8 mediates food-driven resetting of hepatic circadian clock in mice

(2019) Siyu Chen et al.   Nature Communications

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

(2018) Daniel F. Vatner et al.   DIABETOLOGIA

GLP-1 receptor agonists stimulate ANGPTL8 production through the PI3K/Akt pathway in a GLP-1 receptor-dependent manner

(2018) Junling Liu et al.   PEPTIDES

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

(2018) Serena Banfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-Like Protein 8 Is a Novel Vitamin D Receptor Target Gene Involved in Non-Alcoholic Fatty Liver Pathogenesis

(2018) Carmelo García-Monzón et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiopoietin-like 8 Improves Insulin Resistance and Attenuates Adipose Tissue Inflammation in Diet-Induced Obese Mice

(2018) Deng Luo et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats

(2018) Ryota Izumi et al.   JOURNAL OF LIPID RESEARCH

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiopoietin-like 3 in lipoprotein metabolism

(2017) Sander Kersten   Nature Reviews Endocrinology

Regulation of hepatic glucose metabolism in health and disease

(2017) Max C. Petersen et al.   Nature Reviews Endocrinology

ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ

(2017) Yu Zhang et al.   Nature Communications

Insulin upregulates betatrophin expression via PI3K/Akt pathway

(2017) Puhan Lu et al.   Scientific Reports

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

(2017) Xun Chi et al.   Molecular Metabolism

Regulation of lipid metabolism by angiopoietin-like proteins

(2016) Wieneke Dijk et al.   CURRENT OPINION IN LIPIDOLOGY

ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3β or Akt-FoxO1 pathway in HepG2 cells

(2016) Xing Rong Guo et al.   EXPERIMENTAL CELL RESEARCH

Epigenomic and transcriptional control of insulin resistance

(2016) E. D. Rosen   JOURNAL OF INTERNAL MEDICINE

The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking

(2016) Ren Zhang   Open Biology

Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism

(2016) Cheng Han et al.   Biomed Research International

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

(2015) Aaron R. Cox et al.   DIABETOLOGIA

In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats

(2015) Jiaxi Chen et al.   DIABETOLOGIA

Circulating Betatrophin Levels Are Increased in Patients With Type 2 Diabetes and Associated With Insulin Resistance

(2015) Xi Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia

(2015) Klaus G. Parhofer   Diabetes & Metabolism Journal

CREB and FoxO1: two transcription factors for the regulation of hepatic gluconeogenesis

(2014) Kyoung-Jin Oh et al.   BMB Reports

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

(2014) Viktoria Gusarova et al.   CELL

Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients

(2014) Hao Hu et al.   DIABETES CARE

Emerging roles of Lipasin as a critical lipid regulator

(2013) Ren Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New hormone stimulates pancreatic β-cell proliferation

(2013) Judith A Gilbert   Lancet Diabetes & Endocrinology

Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism

(2012) Gang Ren et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family

(2012) Zhiyao Fu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

(2011) Hua V. Lin et al.   Cell Metabolism

The interaction of hepatic lipid and glucose metabolism in liver diseases

(2011) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Effects of Insulin on the Metabolic Control of Hepatic Gluconeogenesis In Vivo

(2009) Dale S. Edgerton et al.   DIABETES