Article
Immunology
Loic Angrand, Wahid Boukouaci, Mohamed Lajnef, Jean-Romain Richard, Ana Andreazza, Chieng-Lien Wu, Jihene Bouassida, Ismail Rafik, Marianne Foiselle, Esma Mezouad, Soumia Naamoune, Leila Chami, Ons Mihoub, Sofiane Salah, Arij Benchaaben, Philippe Le Corvoisier, Caroline Barau, Bruno Costes, Robert Yolken, Guillemette Crepeaux, Marion Leboyer, Ryad Tamouza
Summary: The study found that patients with bipolar disorder have lower levels of mitochondrial DNA copy number, particularly during manic episodes. These low levels were negatively correlated with mood and psychotic symptom scales, but positively correlated with severity scales. Additionally, they were correlated with high levels of certain inflammatory markers.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Review
Neurosciences
Camilla Elefante, Giulio Emilio Brancati, Samuele Torrigiani, Salvatore Amadori, Sara Ricciardulli, Gabriele Pistolesi, Lorenzo Lattanzi, Giulio Perugi
Summary: This study systematically reviews the clinical features and therapeutic evidence regarding manic syndromes in different types of dementia. The results indicate that manic symptoms are associated with disease progression in Alzheimer's disease, have a variable relationship with cognitive decline in vascular dementia, and often precede or coincide with cognitive impairment in frontotemporal dementia. Mood stabilizers and electroconvulsive therapy appear to be the most effective treatments, while the benefits of short-term treatment with antipsychotic agents need to be balanced with associated risks. Importantly, low-dose lithium salts may have neuroprotective activity in patients with Alzheimer's disease.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Psychiatry
Hua-Meng Shi, De-Guo Jiang
Summary: This study found that mood-incongruent psychosis during the first manic episode of bipolar disorder appears to predict an increased likelihood of persistent psychotic symptoms over the subsequent 24 months. This persistence of psychosis is associated with a worse overall course of illness.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Chih-Ken Chen, Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chian-Jue Kuo, Andrew Tai-Ann Cheng
Summary: This study investigates the effects of individual genomics and antidepressant medication on the risk of manic switch in bipolar I disorder. The results suggest that the rs10262219 variant on chromosome 7 and antidepressant treatment significantly increase the risk of manic switch after bipolar depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Okan Imre, Mustafa Karaagac, Cuneyt Caglayan
Summary: This study compared vitamin D levels and related metabolites in patients with bipolar manic episodes, patients in remission after treatment, and a healthy control group. The results showed lower vitamin D levels during manic episodes. Further research is needed to investigate other mood episodes.
BEHAVIORAL SCIENCES
(2023)
Article
Psychiatry
R. Ogulcan Ciray, Eren Halac, Serkan Turan, Mustafa Tuncturk, Mutlu Ozbek, Cagatay Ermis
Summary: Analysis of the FAERS database revealed that SSRI drugs are associated with a higher risk of inducing mania in patients with bipolar disorder, with fluvoxamine showing the largest effect size. Significant effects were found for Ki values of H1 and M1 receptors, while receptor occupancy did not appear to have an effect. Further pharmacological data and clinical assessments are needed to validate these findings.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
B. Sirlier Emir, S. Yildiz, A. Kazgan Kilicaslan, F. Kilic, K. Ugur, S. Aydin, M. Atmaca
Summary: This study confirms the association between Klotho and FGF-23 levels and bipolar disorder, and shows that Klotho and FGF-23 levels are significantly increased in patients with bipolar disorder manic episodes. These findings offer new insights into the etiology and treatment of bipolar disorder.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Ya-lin Wang, Hao-ran Wu, Shan-shan Zhang, Hong-lei Xiao, Jin Yu, Yuan-yuan Ma, Yao-dong Zhang, Qiong Liu
Summary: The study confirmed that catalpol exhibits antidepressive effects on CUMS mice by inhibiting NLRP3 and neuroinflammation. Moreover, mitochondrial oxidative stress activity may be associated with NLRP3 activation.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychiatry
Haniya J. Halim, Bradley G. Burk, Rachel E. Fargason, Badari Birur
Summary: Research on psychedelic substances as treatment options for neuropsychiatric conditions is increasing. Psilocybin, a psychedelic drug, has gained interest as an effective treatment for treatment-resistant depression, depression associated with terminal conditions, certain substance use disorders, and obsessive-compulsive disorder. However, there is limited data on the effects of psilocybin on patients at risk for mania, largely due to exclusion from studies. This case study describes a 21-year-old male with bipolar II disorder who experienced a manic episode after ingesting psilocybin.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Yuki Kageyama, Yasuhiko Deguchi, Kotaro Hattori, Sumiko Yoshida, Yu-ichi Goto, Koki Inoue, Tadafumi Kato
Summary: The study found no significant differences in nervonic acid levels in the cerebrospinal fluid among patients with MDD, BD, and healthy controls. However, a significant negative correlation with depressive symptoms and a positive correlation with manic symptoms was observed in MDD and BD patients, respectively. Therefore, nervonic acid levels in the CSF may be a potential biomarker for mood symptoms.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Diana Woodward, Timothy E. Wilens, Amy M. Yule, Maura DiSalvo, Daria Taubin, Amy Berger, Mira Stone, Janet Wozniak, Colin Burke, Joseph Biederman
Summary: This study examined the clinical characteristics and familiality of comorbid Bipolar Disorder (BP) and Conduct Disorder (CD) in children. The results showed that children with comorbid BP + CD had more severe behavioral, social, and neurocognitive problems compared to those with BP alone. Moreover, first-degree relatives of children with BP + CD also had higher rates of behavioral problems and smoking.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Antonio Del Casale, Martina Nicole Modesti, Ludovica Rapisarda, Paolo Girardi, Renata Tambelli
Summary: As the COVID-19 pandemic continues to spread globally, it is having serious consequences on various medical fields, including mental health. Healthcare professionals and the general population are both experiencing increased anxiety, depression, and stress. In addition, individuals with no prior history of psychiatric disorders are developing unusual symptoms following SARS-CoV-2 infection, likely due to the psychological and social issues triggered by the pandemic. This review focuses on the cases of mania in individuals with bipolar disorder (BD) after COVID-19, with or without a psychiatric history. The results suggest that COVID-19 can trigger or unmask BD through social and psychological influences as well as biological pathways. The severity of COVID-19 does not directly correlate with manic symptoms, and specific medical treatment is required for individuals with severe symptoms of both diseases.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Cell Biology
Fernando Lopez Alvez, Natalia Pontes Bona, Nathalia Stark Pedra, Daniel Schuch da Silva, Wilson Joao Cunico, Francieli Moro Stefanello, Cinthia Melazzo de Andrade, Mayara Sandrielly Pereira Soares, Roselia Maria Spanevello
Summary: The study investigated the effect of DS27 on lipopolysaccharide-treated astrocytes. The findings showed that DS27 can reverse cellular damage induced by LPS and improve neuroinflammation.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Natalia Pontes Bona, Mayara Sandrielly Pereira Soares, Nathalia Stark Pedra, Luiza Spohr, Francieli da Silva dos Santos, Alana Seixas de Farias, Fernando Lopez Alvez, Bernardo de Moraes Meine, Karina Pereira Luduvico, Roselia Maria Spanevello, Francieli Moro Stefanello
Summary: Tannic acid (TA) plays an important role in the treatment of glioblastoma, as it modulates purinergic and redox systems.
NEUROCHEMICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Bernardo de Moraes Meine, Thais Scolari Franceschi, Natalia Pontes Bona, Luiza Spohr, Nathalia Stark Pedra, Roselia Maria Spanevello, Mayara Sandrielly Soares de Aguiar, Francieli Moro Stefanello
Summary: This study investigated the effects of chronic administration of methionine and its metabolite methionine sulfoxide on oxidative damage in the brain, liver, and kidney of young mice. The results showed that these substances increased reactive oxygen species and lipoperoxidation levels, while reducing antioxidant enzyme activities. Furthermore, they also affected the liver and kidney functions. These findings contribute to a better understanding of the pathophysiological mechanisms of hypermethioninemia.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Nathalia Stark Pedra, Kirley Marques Canuto, Ana Sheila de Queiroz Souza, Paulo Riceli Vasconcelos Ribeiro, Natalia Pontes Bona, Roberto Ramos-Sobrinho, Priscila Oliveira de Souza, Roselia Maria Spanevello, Elizandra Braganhol
Summary: Endophytic fungus Biscogniauxia sp. was isolated from the medicinal plant Achyrocline satureioides, and its secondary metabolites were evaluated for their cytotoxic properties in a human melanoma cell line (A375). A total of 17 secondary metabolites, including polyketide derivatives, terpenoids, and isocoumarins, were identified. The purified F-DCM fraction significantly inhibited the viability and proliferation of melanoma cells and induced apoptosis/necrosis and cell cycle arrest. Biscogniauxia sp. of A. satureioides has the potential to be a valuable source of compounds with therapeutic applications.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Juliane De Souza Cardoso, Fernanda Cardoso Teixeira, Julia Eisenhardt De Mello, Mayara Sandrielly Soares De Aguiar, Pathise Souto Oliveira, Juliane Torchelsen Saraiva, Marcia Vizzotto, Fabiane Borelli Grecco, Claiton Leoneti Lencina, Roselia Maria Spanevello, Rejane Giacomelli Tavares, Francieli Moro Stefanello
Summary: This study aimed to investigate the role of Psidium cattleianum extract (PCE) in treating type 2 diabetes mellitus (T2DM) and compare its effects with metformin (Met). T2DM was induced in rats with a high-fat diet and streptozotocin. Both PCE and Met effectively prevented the increase in glucose, cholesterol, triglycerides, VLDL, and IL-6 levels caused by T2DM, and restored redox homeostasis in the liver and brain. PCE showed superior effectiveness in recovering histological changes in the liver and pancreas. In conclusion, PCE shows promise as a preventative agent for T2DM complications.
Article
Neurosciences
Alessandra dos Santos, Fernanda Cardoso Teixeira, Daniel Schuch da Silva, Tayna Amaral Veleda, Julia Eisenhart de Mello, Karina Pereira Luduvico, Rejane Giacomelli Tavares, Francieli Moro Stefanello, Wilson Cunico, Roselia Maria Spanevello
Summary: Alzheimer's disease (AD) is characterized by memory decline and limited treatment options. Thiazolidin-4-one, a compound with multiple beneficial effects, was evaluated for its potential therapeutic effects in an AD model induced by streptozotocin (STZ). Treatment with DS12, a thiazolidin-4-one compound, improved memory and prevented neurochemical changes induced by STZ. DS12 also protected against oxidative damage in the brain without causing toxic effects.
BRAIN RESEARCH BULLETIN
(2023)
Article
Endocrinology & Metabolism
Julia Eisenhardt de Mello, Karina Pereira Luduvico, Alessandra dos Santos, Fernanda Cardoso Teixeira, Juliane de Souza Cardoso, Mayara Sandrielly Soares de Aguiar, Wilson Cunico, Marcia Vizzotto, Francieli Stefanello, Roselia Spanevello
Summary: The study evaluated the effects of blackberry extract on memory and neurochemical parameters in rats with scopolamine-induced amnesia. The results showed that blackberry extract can prevent memory impairment, reduce oxidative damage, and inhibit acetylcholinesterase activity caused by scopolamine. Therefore, blackberry extract has potential therapeutic applications for neurodegenerative diseases.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Luiza Spohr, Mayara Sandrielly Soares de Aguiar, Natalia Pontes Bona, Karina Pereira Luduvico, Amalia Goncalves Alves, William Borges Domingues, Eduardo Bierhals Blodorn, Cristiani Folharini Bortolatto, Cesar Augusto Bruning, Vinicius Farias Campos, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: This study found that blueberry extract improved depression-like behavior and attenuated neurochemical and molecular changes in the brains of mice challenged with LPS.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Priscila Centeno Crespo, Leo Anderson Meira Martins, Clara Camacho Dos Reis, Liciane Fernandes Medeiros, Vanessa Leal Scarabelot, Giovana Duzzo Gamaro, Mayara Sandrielly Pereira Soares, Roselia Maria Spanevello, Francieli Moro Stefanello, Izabel Cristina Custodio De Souza
Summary: This study analyzed the effects of transcranial direct current stimulation (tDCS) on biochemical parameters in rats with neuropathic pain. The results showed that tDCS increased the total sulfhydryl content in the spinal cord of rats, positively modulating neuropathic pain.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Albert Layo Costa de Assis, Patricia de Araujo Rodrigues, Selene Maia de Morais, Ana Livya Moreira Rodrigues, Jessica Maria Pessoa Gomes, Tyciane de Souza Nascimento, Alfaete Vieira Oliveira, Mayara Sandrielly Soares de Aguiar, Geanne Matos de Andrade
Summary: This study evaluated the cytoprotective activity of B. sericea ethanolic extract (BSEE) in a Parkinson's disease cell model. The results showed that BSEE had antioxidant and anti-apoptotic effects, suggesting its potential as a cytoprotective agent for Parkinson's disease.
NEUROCHEMICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
R. O. Leite, P. O. de Souza, C. B. Haas, F. da Silveira, K. R. Mohr, A. P. S. Bertoni, M. S. Soares, J. H. Azambuja, M. Dal Pra, L. L. P. da Cruz, N. E. Gelsleichter, K. Begnini, G. Hasko, M. R. Wink, R. M. Spanevello, E. Braganhol
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection. Purinergic signaling, mediated by purines such as ATP and adenosine, plays a crucial role in the immune and inflammatory responses during sepsis. Sepsis disrupts the balance of ATP and adenosine levels, leading to dysregulation of immune responses. The measurement of serum levels and activities of purinergic pathway markers may serve as potential biomarkers for sepsis diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Plant Sciences
Natalia Pontes Bona, Mayara Sandrielly Soares de Aguiar, Luiza Spohr, Nathalia Stark Pedra, Francieli da Silva dos Santos, Juliane Torchelsen Saraiva, Fernando Lopez Alvez, Bernardo de Moraes Meine, Vania Recart, Ingrid Vicente Farias, Caroline Flach Ortmann, Roselia Maria Spanevello, Flavio Henrique Reginatto, Francieli Moro Stefanello
Summary: The extract and enriched flavonoid fraction from Cecropia pachystachya demonstrate neuroprotective and anti-inflammatory effects in a model of LPS-induced neuroinflammation, making them potential therapeutic targets for managing neurodegenerative diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)