Article
Plant Sciences
Ming-Yang Chen, Qing-Yi Xie, Fan-Dong Kong, Qing-Yun Ma, Li-Man Zhou, Jing-Zhe Yuan, Hao-Fu Dai, You-Gen Wu, You-Xing Zhao
Summary: Two new compounds, epipaxilline (1) and penerpene J (2), were isolated from the marine-derived fungus Penicillium sp. KFD28. They showed inhibitory activities against PTP1B and TCPTP.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2021)
Article
Chemistry, Medicinal
Jinwei Ren, Ruiyun Huo, Gaoran Liu, Ling Liu
Summary: Three new andrastin-type meroterpenoids, penimeroterpenoids A-C (1-3), along with two known analogs, were isolated from the cultures of marine-derived Penicillium species. The structures of the new compounds were identified through NMR and mass spectrometry, while the absolute configurations were determined using experimental and calculated ECD spectra. Compound 1 exhibited moderate cytotoxicity against A549, HCT116, and SW480 cell lines.
Article
Chemistry, Applied
Sen Pang, Zhi-Gang Guo, Li Wang, Qing-Feng Guo, Fei Cao
Summary: A new indole-diterpenoid, penijanthine E (1), and a known analogue (2), were isolated from the PDB culture of the marine-derived fungus Penicillium citrinum ZSS-9. The absolute configurations of compounds 1 and 2 were determined using various methods including TDDFT ECD, DP4plus calculations, and single-crystal X-ray diffraction analysis. Both compounds exhibited antiviral activity against influenza A virus (IAV) strains, with IC50 values ranging from 12.6 to 46.8 μM.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Danmei Tian, Xiaoshuang Gou, Jia Jia, Jihua Wei, Mingxin Zheng, Wenjuan Ding, Hongkai Bi, Bin Wu, Jinshan Tang
Summary: Marine-derived fungi have the potential to produce novel metabolites with biological activities. In this study, new compounds isolated from a marine-derived fungus showed moderate antibacterial activity against Helicobacter pylori, indicating their potential as lead compounds for the treatment of H. pylori infection.
Article
Plant Sciences
Ya-Hui Zhang, Lei Li, Ya-Qi Li, Jia-Hua Luo, Wan Li, Long-Fei Li, Cai-Juan Zheng, Fei Cao
Summary: Two unusual indole-diterpenoid derivatives were isolated from a marine-derived fungus, showing antiviral activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Fei Zhang, Li Yang, Qing-Yi Xie, Jiao-Cen Guo, Qing-Yun Ma, Lu-Ting Dai, Li-Man Zhou, Hao-Fu Dai, Fan-Dong Kong, Du-Qiang Luo, You-Xing Zhao
Summary: Eight previously undescribed indole-diterpenoids were isolated from the marine soft coral-derived fungus Aspergillus sp. ZF-104, along with seven known analogues. Their structures and absolute configurations were determined through spectroscopic data, ECD analysis, and quantum ECD and NMR calculations. Several of these compounds showed comparable protein tyrosine phosphatase 1B inhibitory activity to the positive control.
Article
Chemistry, Medicinal
You-Jia Hao, Zheng-Biao Zou, Ming-Min Xie, Yong Zhang, Lin Xu, Hao-Yu Yu, Hua-Bin Ma, Xian-Wen Yang
Summary: Two new xanthones (1 and 2) were isolated from deep-sea-derived fungus Penicillium sp. MCCC 3A00126, along with 34 known compounds (3-36). The structures of the new compounds were determined using spectroscopic data. The absolute configuration of compound 1 was confirmed by comparing experimental and calculated ECD spectra. Cytotoxicity and ferroptosis inhibitory activities of all isolated compounds were evaluated. Compounds 14 and 15 showed potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 μM, respectively. Compounds 26, 28, 33, and 34 exhibited significant inhibitory effects on RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 μM, respectively.
Article
Biochemistry & Molecular Biology
Chao-Feng Wang, Xiao-Fang Huang, Hong-Xiu Xiao, You-Jia Hao, Lin Xu, Qing-Xiang Yan, Zheng-Biao Zou, Chun-Lan Xie, Yan-Qin Xu, Xian-Wen Yang
Summary: One new compound (d-arabinitol-anofinicate, 1) and fourteen known compounds (2-15) were isolated from the marine Penicillium sp. MCCC 3A00228. The structure of the new compound was mainly determined by extensive spectroscopic analyses. Compound 1 exhibited weak transcriptional effect on Nur77, while compound 13 showed moderate in vitro anti-proliferative effects against tumor cells.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xuan Hong, Xiaoqing Guan, Qiliang Lai, Dehua Yu, Zhongwei Chen, Xiaoteng Fu, Beibei Zhang, Changkun Chen, Zongze Shao, Jinmei Xia, Jiang-Jiang Qin, Weiyi Wang
Summary: A new meroterpenoid, taladrimanin A (1), was isolated from a marine-derived fungus, and its structure and activity were studied. Compound 1 showed inhibitory activity against gastric cancer cells and certain bacteria.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Tao Chen, Wencong Yang, Taobo Li, Yihao Yin, Yufeng Liu, Bo Wang, Zhigang She
Summary: Four new compounds, including a unique compound with a congested ring system, were isolated from the cultures of a marine-derived fungus. These compounds showed significant antimicrobial activities.
Article
Chemistry, Medicinal
Xiuli Xu, Jiangpeng Li, Kai Zhang, Shangzhu Wei, Rui Lin, Steven W. Polyak, Na Yang, Fuhang Song
Summary: Nine new secondary metabolites, including six isocoumarin analogues and three compounds with a rare skeleton of isocoumarin coupled with phenylethylamine, were isolated and identified from the marine-derived fungus Paraphoma sp. CUGBMF180003. The chemical structures were determined using spectroscopic data, and two compounds showed strong antibacterial activity against Staphylococcus aureus.
Article
Microbiology
Cankai Lin, Rongchun Huang, Juntao Liu, Hong Li, Liping Zhu, Xin Huang, Bo Ding, Lan Liu, Hongbo Huang, Yiwen Tao
Summary: Seven new polyketides were isolated and identified from a marine-derived fungus. Some of these compounds exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus, while one compound demonstrated moderate cytotoxicity against human cancer cell lines.
Article
Microbiology
Xiaoyan Pang, Weihao Chen, Xin Wang, Xuefeng Zhou, Bin Yang, Xinpeng Tian, Junfeng Wang, Shihai Xu, Yonghong Liu
Summary: This study isolated multiple new compounds from cultures of the deep-sea-derived fungus Penicillium sp., and determined their structures and activities through various analyses. Compound 3 exhibited potent inhibitory activities against Staphylococcus aureus and methicillin-resistant S. aureus, as well as some weak antiviral activity against the SARS-CoV-2 main protease responsible for the COVID-19 pandemic.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Fei-Hua Yao, Xiao Liang, Xin-Hua Lu, Xia Cheng, Lian-Xiang Luo, Shu-Hua Qi
Summary: Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Compound 13 exhibited significant inhibitory activity against protein tyrosine phosphatases. Moreover, compounds 1, 2, 5, 8-10, 12, and 13 showed antibacterial activity.
JOURNAL OF NATURAL PRODUCTS
(2022)