Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells

Combining Radiotherapy With Anti-angiogenic Therapy and Immunotherapy; A Therapeutic Triad for Cancer?

(2019) Ruben S. A. Goedegebuure et al.   Frontiers in Immunology

The unique invasiveness of glioblastoma and possible drug targets on extracellular matrix

(2019) Adam Hatoum et al.   Cancer Management and Research

The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells

(2019) Majid Momeny et al.   CELLULAR ONCOLOGY

Cancer therapeutics using survivin BIRC5 as a target: what can we do after over two decades of study?

(2019) Fengzhi Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Selected by gene co-expression network and molecular docking analyses, ENMD-2076 is highly effective in glioblastoma-bearing rats

(2019) Sheng Zhong et al.   Aging-US

Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1–Survivin axis

(2019) Jun-Hai Tang et al.   Cancer Communications

Diversity and functional evolution of the plasminogen activator system

(2018) Rishi Kumar Jaiswal et al.   BIOMEDICINE & PHARMACOTHERAPY

Cabozantinib, a New Standard of Care for Patients With Advanced Renal Cell Carcinoma and Bone Metastases? Subgroup Analysis of the METEOR Trial

(2018) Bernard Escudier et al.   JOURNAL OF CLINICAL ONCOLOGY

VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes glioblastoma maintenance

(2018) Signe R Michaelsen et al.   NEURO-ONCOLOGY

MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells

(2018) Sarmistha Talukdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell death-based treatment of glioblastoma

(2018) Simone Fulda   Cell Death & Disease

Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma

(2018) Shabierjiang JIAPAER et al.   NEUROLOGIA MEDICO-CHIRURGICA

The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells

(2017) Maria Grazia Atzori et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells

(2017) Majid Momeny et al.   Scientific Reports

Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

(2016) C. Kurokawa et al.   JOURNAL OF NEURO-ONCOLOGY

Autocrine VEGFR1 and VEGFR2 signaling promotes survival in human glioblastoma models in vitro and in vivo

(2016) Emese Szabo et al.   NEURO-ONCOLOGY

The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences

(2016) Estelle Willems et al.   Targeted Oncology

Phase I/II Randomized Trial of Sorafenib and Bevacizumab as First-Line Therapy in Patients with Locally Advanced or Metastatic Hepatocellular Carcinoma: North Central Cancer Treatment Group Trial N0745 (Alliance)

(2016) Joleen M. Hubbard et al.   Targeted Oncology

Survivin and gliomas: A literature review

(2016) Rosilin Kotakkathu Varughese et al.   Oncology Letters

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

Lessons From Anti–Vascular Endothelial Growth Factor and Anti–Vascular Endothelial Growth Factor Receptor Trials in Patients With Glioblastoma

(2015) Christine Lu-Emerson et al.   JOURNAL OF CLINICAL ONCOLOGY

Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism

(2015) H. Shen et al.   MOLECULAR CANCER THERAPEUTICS

Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines

(2015) Majid Momeny et al.   Oncotarget

Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma

(2015) Sri Hari Krishna Vellanki et al.   NEOPLASIA

Dual inhibition of the vascular endothelial growth factor pathway: A phase 1 trial evaluating bevacizumab and AZD2171 (cediranib) in patients with advanced solid tumors

(2014) David S. Hong et al.   CANCER

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Role of AKT signaling in DNA repair and clinical response to cancer therapy

(2014) Q. Liu et al.   NEURO-ONCOLOGY

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: Implications for stem cell mitosis and centrosome dynamics

(2014) Mariella Mannino et al.   Stem Cell Research

Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance

(2014) P Dahan et al.   Cell Death & Disease

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

Invasion as target for therapy of glioblastoma multiforme

(2013) Anne Vehlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Anti-tumour and anti-vascular effects of cediranib (AZD2171) alone and in combination with other anti-tumour therapies

(2013) Jane Kendrew et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phase II Study of Bevacizumab in Combination with Sorafenib in Recurrent Glioblastoma (N0776): A North Central Cancer Treatment Group Trial

(2013) E. Galanis et al.   CLINICAL CANCER RESEARCH

Gene Expression Profile Identifies Tyrosine Kinase c-Met as a Targetable Mediator of Antiangiogenic Therapy Resistance

(2013) A. Jahangiri et al.   CLINICAL CANCER RESEARCH

Glioblastoma Resistance to Anti-VEGF Therapy: Has the Challenge Been MET?

(2013) J. H. McCarty   CLINICAL CANCER RESEARCH

Sorafenib and bevacizumab combination targeted therapy in advanced neuroendocrine tumour: A phase II study of Spanish Neuroendocrine Tumour Group (GETNE0801)

(2013) Daniel Castellano et al.   EUROPEAN JOURNAL OF CANCER

Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma

(2013) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Review: Molecular mechanism of microglia stimulated glioblastoma invasion

(2013) Salvatore J. Coniglio et al.   MATRIX BIOLOGY

Akt and c-Myc Induce Stem-Cell Markers in Mature Primary p53−/− Astrocytes and Render These Cells Gliomagenic in the Brain of Immunocompetent Mice

(2013) Josefine Radke et al.   PLoS One

Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation

(2013) J. Silke et al.   Cold Spring Harbor Perspectives in Biology

Targeting the Akt-pathway to Improve Radiosensitivity in Glioblastoma

(2012) Ravi S. Narayan et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic targeting of VEGF in the treatment of glioblastoma

(2012) Lizbeth Robles Irizarry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown

(2012) Patricia L.C. Lopez et al.   ONCOLOGY

The Role of Bcl-2 Family Proteins in Therapy Responses of Malignant Astrocytic Gliomas: Bcl2L12 and Beyond

(2012) Fotini M. Kouri et al.   TheScientificWorldJOURNAL

Myc proteins in brain tumor development and maintenance

(2012) Fredrik J. Swartling   UPSALA JOURNAL OF MEDICAL SCIENCES

Enhanced antitumor efficacy by blocking activation of the phosphatidylinositol 3-kinase/Akt pathway during anti-angiogenesis therapy

(2011) Yu Wei Zhao et al.   CANCER SCIENCE

Knockdown of cyclin D1 inhibits proliferation, induces apoptosis, and attenuates the invasive capacity of human glioblastoma cells

(2011) JunYu Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

(2011) Hari Raghu et al.   Molecular Cancer

Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family

(2011) S. R. Brave et al.   MOLECULAR CANCER THERAPEUTICS

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Autocrine regulation of glioblastoma cell-cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay

(2010) Petra Knizetova et al.   CELL CYCLE

Survivin Is a Potential Mediator of Prostate Cancer Metastasis

(2010) Min Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiation Resistance in Glioma Cells Determined by DNA Damage Repair Activity of Ape1/Ref-1

(2010) Mamta D. NAIDU et al.   JOURNAL OF RADIATION RESEARCH

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Standard Therapy for Glioblastoma— A Review of Where We Are

(2010) Ryo NISHIKAWA   NEUROLOGIA MEDICO-CHIRURGICA

Cediranib: profile of a novel anti-angiogenic agent in patients with glioblastoma

(2009) Jörg Dietrich et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

FDA Drug Approval Summary: Bevacizumab (Avastin(R)) as Treatment of Recurrent Glioblastoma Multiforme

(2009) M. H. Cohen et al.   ONCOLOGIST

Increased Survivin Expression Confers Chemoresistance to Tumor-Associated Endothelial Cells

(2008) Jenilyn J. Virrey et al.   AMERICAN JOURNAL OF PATHOLOGY

Urokinase directly activates matrix metalloproteinases-9: A potential role in glioblastoma invasion

(2008) Yunge Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition

(2008) Alexandre Bozec et al.   EUROPEAN JOURNAL OF CANCER

Combination of antiangiogenesis with chemotherapy for more effective cancer treatment

(2008) J. Ma et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

(2008) Tomoya Kitamura et al.   NATURE CELL BIOLOGY

Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM

(2008) Rose Du et al.   NEURO-ONCOLOGY

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

(2008) K E Tagscherer et al.   ONCOGENE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY