Loss of function mutations of BCOR in classical Hodgkin lymphoma

Molecular biology of Hodgkin lymphoma

(2021) Marc A. Weniger et al.   LEUKEMIA

OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR

(2020) Michelle Y. Hamline et al.   DEVELOPMENTAL BIOLOGY

Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies

(2020) Satoshi Kaito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

(2019) Madison J. Kelly et al.   Nature Communications

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors

(2019) Jessica A. Kotov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma

(2018) Valeria Spina et al.   BLOOD

Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells

(2018) Marc A. Weniger et al.   JOURNAL OF CLINICAL INVESTIGATION

New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes

(2018) Elsa Maitre et al.   Oncotarget

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome

(2018) Shiro Tara et al.   BLOOD

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2 , TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma

(2017) Laurent Jallades et al.   HAEMATOLOGICA

An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

(2017) A Lollies et al.   LEUKEMIA

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

(2017) Marcus Lefebure et al.   Nature Communications

Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2 , TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma

(2017) Laurent Jallades et al.   HAEMATOLOGICA

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia

(2016) Cristina López et al.   BRITISH JOURNAL OF HAEMATOLOGY

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma

(2016) F Linke et al.   LEUKEMIA

BCOR regulates myeloid cell proliferation and differentiation

(2016) Q Cao et al.   LEUKEMIA

Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity

(2016) Shaojun Xing et al.   NATURE IMMUNOLOGY

MLL3/MLL4/COMPASS Family on Epigenetic Regulation of Enhancer Function and Cancer

(2016) Christie C. Sze et al.   Cold Spring Harbor Perspectives in Medicine

Polycomb genes, miRNA, and their deregulation in B-cell malignancies

(2015) G. G. Wang et al.   BLOOD

Alterations of theCD58gene in classical Hodgkin lymphoma

(2015) Markus Schneider et al.   GENES CHROMOSOMES & CANCER

Context-dependent actions of Polycomb repressors in cancer

(2015) M Koppens et al.   ONCOGENE

The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing

(2014) Y Liu et al.   LEUKEMIA

Polycomb complexes in stem cells and embryonic development

(2013) L. Aloia et al.   DEVELOPMENT

Hodgkin-Reed-Sternberg Cells in Classical Hodgkin Lymphoma Show Alterations of Genes Encoding the NADPH Oxidase Complex and Impaired Reactive Oxygen Species Synthesis Capacity

(2013) Maciej Giefing et al.   PLoS One

Structure of the Polycomb Group Protein PCGF1 in Complex with BCOR Reveals Basis for Binding Selectivity of PCGF Homologs

(2013) Sarah E. Junco et al.   STRUCTURE

Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma

(2012) E. Tiacci et al.   BLOOD

Hodgkin lymphoma

(2012) Ralf Küppers et al.   JOURNAL OF CLINICAL INVESTIGATION

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

(2010) Björn Lamprecht et al.   NATURE MEDICINE

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE