Molecular biology of Hodgkin lymphoma

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma

(2020) Masaharu Kawashima et al.   LEUKEMIA

Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

(2020) Lorenz Thurner et al.   Nature Communications

A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

(2020) Fathima Zumla Cader et al.   NATURE MEDICINE

The critical role of CD4+ T cells in PD-1 blockade against MHC-II–expressing tumors such as classic Hodgkin lymphoma

(2020) Joji Nagasaki et al.   Blood Advances

Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1

(2020) Sarah Reinke et al.   BLOOD

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

(2019) Ann-Kathrin Desch et al.   LEUKEMIA

Stable FIX Expression and Durable Reductions in Bleeding and Factor IX Consumption for up to 4 Years Following AMT-060 Gene Therapy in Adults with Severe or Moderate-Severe Hemophilia B

(2019) Wolfgang Miesbach et al.   BLOOD

Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma

(2019) Tomohiro Aoki et al.   Cancer Discovery

Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL

(2018) Frank Vari et al.   BLOOD

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma

(2018) Enrico Tiacci et al.   BLOOD

Mass cytometry of Hodgkin lymphoma reveals a CD4+exhausted T-effector and T-regulatory cell rich microenvironment

(2018) Fathima Zumla Cader et al.   BLOOD

Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma

(2018) Valeria Spina et al.   BLOOD

Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells

(2018) Marc A. Weniger et al.   JOURNAL OF CLINICAL INVESTIGATION

Major Histocompatibility Complex Class II and Programmed Death Ligand 1 Expression Predict Outcome After Programmed Death 1 Blockade in Classic Hodgkin Lymphoma

(2018) Margaretha G.M. Roemer et al.   JOURNAL OF CLINICAL ONCOLOGY

Chromosomal Instability in Hodgkin Lymphoma: An In-Depth Review and Perspectives

(2018) Corina Cuceu et al.   Cancers

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

(2018) Benjamin Edginton-White et al.   LEUKEMIA

An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

(2017) A Lollies et al.   LEUKEMIA

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

(2017) K Vrzalikova et al.   LEUKEMIA

Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma

(2017) Frederik Wein et al.   Cancer Immunology Research

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

(2016) Jing Du et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

(2016) V. Camus et al.   HAEMATOLOGICA

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

(2016) Margaretha G.M. Roemer et al.   JOURNAL OF CLINICAL ONCOLOGY

NF-κB deregulation in Hodgkin lymphoma

(2016) Marc A. Weniger et al.   SEMINARS IN CANCER BIOLOGY

Novel agents in the treatment of Hodgkin lymphoma: Biological basis and clinical results

(2016) Anas Younes et al.   SEMINARS IN HEMATOLOGY

Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis

(2016) Hanfeng Guan et al.   Oncotarget

A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses

(2016) Kivia A. P. de Oliveira et al.   Genome Medicine

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

(2016) V. Camus et al.   HAEMATOLOGICA

Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma

(2015) Sylvia Hartmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Alterations of theCD58gene in classical Hodgkin lymphoma

(2015) Markus Schneider et al.   GENES CHROMOSOMES & CANCER

Recurrent somatic loss ofTNFRSF14in classical Hodgkin lymphoma

(2015) Stephen J. Salipante et al.   GENES CHROMOSOMES & CANCER

The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

(2015) David Dominguez-Sola et al.   IMMUNITY

PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones

(2015) Sandrine Sander et al.   IMMUNITY

The role of T cells in the microenvironment of Hodgkin lymphoma

(2015) Frederik Wein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma

(2015) S Hartmann et al.   LEUKEMIA

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

(2014) J. Reichel et al.   BLOOD

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

(2014) Ji-Young Choe et al.   BMC CANCER

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma

(2014) Jay Gunawardana et al.   NATURE GENETICS

The EBV oncogene LMP1 protects lymphoma cells from cell death through the collagen-mediated activation of DDR1

(2013) F. Z. Cader et al.   BLOOD

Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells

(2013) P. Greaves et al.   BLOOD

Protrusion-guided extracellular vesicles mediate CD30 trans-signalling in the microenvironment of Hodgkin's lymphoma

(2013) Hinrich P Hansen et al.   JOURNAL OF PATHOLOGY

Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells

(2013) B. Rengstl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

(2012) H. Yuki et al.   BLOOD

Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma

(2012) E. Tiacci et al.   BLOOD

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma

(2012) L. Xie et al.   BLOOD

Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma

(2012) Claudia Otto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Expression of CD137 on Hodgkin and Reed-Sternberg Cells Inhibits T-cell Activation by Eliminating CD137 Ligand Expression

(2012) W. T. Ho et al.   CANCER RESEARCH

Hodgkin lymphoma

(2012) Ralf Küppers et al.   JOURNAL OF CLINICAL INVESTIGATION

State of the art in the treatment of Hodgkin lymphoma

(2012) Peter Borchmann et al.   Nature Reviews Clinical Oncology

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

(2011) Christian Steidl et al.   NATURE

Tumorigenic Potential of Mononucleated Small Cells of Hodgkin Lymphoma Cell Lines

(2010) Jun-ichiro Ikeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

(2010) M. R. Green et al.   BLOOD

Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome

(2010) C. Steidl et al.   BLOOD

Cooperative Epigenetic Modulation by Cancer Amplicon Genes

(2010) Lixin Rui et al.   CANCER CELL

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

(2010) Björn Lamprecht et al.   NATURE MEDICINE

Mutations in the genes coding for the NF- B regulating factors I B  and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma

(2009) M. A. Schumacher et al.   HAEMATOLOGICA

Mutations ofNFKBIA, encoding IκBα, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases

(2009) Annette Lake et al.   INTERNATIONAL JOURNAL OF CANCER

Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma

(2009) Lara Cattaruzza et al.   INTERNATIONAL JOURNAL OF CANCER

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

CD30-Induced Signaling Is Absent in Hodgkin's Cells but Present in Anaplastic Large Cell Lymphoma Cells

(2008) Burkhard Hirsch et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis

(2008) F. A. Scheeren et al.   BLOOD

Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3 

(2008) B. Lamprecht et al.   BLOOD

PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma

(2008) R. Yamamoto et al.   BLOOD

Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization

(2008) S. Hartmann et al.   HAEMATOLOGICA

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis

(2008) Verena Brune et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CD4+CD26− T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile

(2008) Yue Ma et al.   LABORATORY INVESTIGATION

Expression of CCR5 receptors on Reed–Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions

(2007) Donatella Aldinucci et al.   INTERNATIONAL JOURNAL OF CANCER

Autocrine NGFβ/TRKA signalling is an important survival factor for Hodgkin lymphoma derived cell lines

(2007) Christoph Renné et al.   LEUKEMIA RESEARCH