Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings

Building a Toolbox for the Analysis and Prediction of Ligand and Catalyst Effects in Organometallic Catalysis

(2021) Derek J. Durand et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cross-Coupling of Ketone Enolates with Grignard and Zinc Reagents with First-Row Transition Metal Catalysts

(2021) Youssef Nassar et al.   ACS Catalysis

Data Science Meets Physical Organic Chemistry

(2021) Jennifer M. Crawford et al.   ACCOUNTS OF CHEMICAL RESEARCH

Data-science driven autonomous process optimization

(2021) Melodie Christensen et al.   Communications Chemistry

Univariate classification of phosphine ligation state and reactivity in cross-coupling catalysis

(2021) Samuel H. Newman-Stonebraker et al.   SCIENCE

Visualization of very large high-dimensional data sets as minimum spanning trees

(2020) Daniel Probst et al.   Journal of Cheminformatics

( E )‐,( Z )‐Stereodefined α‐Chloro‐β‐tosyloxy‐α,β‐unsaturated Esters: Sequential Cross‐couplings for ( E )‐,( Z )‐Stereo complementary Synthesis of Fully‐substituted α,β‐Unsaturated Esters

(2020) Yuichiro Ashida et al.   Asian Journal of Organic Chemistry

Small Phosphine Ligands Enable Selective Oxidative Addition of Ar–O over Ar–Cl Bonds at Nickel(0)

(2020) Emily D. Entz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DFT Protocol for the Prediction of 31P NMR Chemical Shifts of Phosphine Ligands in First-Row Transition-Metal Complexes

(2020) Pierre-Adrien Payard et al.   ORGANOMETALLICS

Cross-Coupling Reactions of Double or Triple Electrophilic Templates for Alkene Synthesis

(2020) Tomáš Tobrman et al.   SYNTHESIS-STUTTGART

Vanadium-Catalyzed Synthesis of Geometrically Defined Acyclic Tri- and Tetrasubstituted Olefins from Propargyl Alcohols

(2019) Barry M. Trost et al.   ACS Catalysis

Highly E-Selective, Stereoconvergent Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling of Alkenyl Ethers

(2019) Guo-Ming Ho et al.   ORGANIC LETTERS

Cobalt-Catalyzed Cross-Couplings between Alkenyl Acetates and Aryl- or Alkenyl-Zinc Pivalates

(2018) Jie Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidating the Role of the Boronic Esters in the Suzuki–Miyaura Reaction: Structural, Kinetic, and Computational Investigations

(2018) Andy A. Thomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

E–Z isomerization in Suzuki cross-couplings of haloenones: ligand effects and evidence for a separate catalytic cycle

(2018) Navneet K. Chehal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Predictive and mechanistic multivariate linear regression models for reaction development

(2018) Celine B. Santiago et al.   Chemical Science

Taming Nickel-Catalyzed Suzuki-Miyaura Coupling: A Mechanistic Focus on Boron-to-Nickel Transmetalation

(2018) Pierre-Adrien Payard et al.   ACS Catalysis

Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

(2018) Nirmalya Mukherjee et al.   Organic Chemistry Frontiers

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin

(2018) Scott Savage et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoretentive Suzuki–Miyaura and Kumada–Tamao–Corriu Cross-Couplings for Preparing (E)- and (Z)-Stereodefined, Fully Substituted α,β-Unsaturated Esters: Application for a Pharmacophore Synthesis

(2018) Yoo Tanabe et al.   SYNTHESIS-STUTTGART

Ligation state of nickel during C O bond activation with monodentate phosphines

(2018) Leidy V. Hooker et al.   TETRAHEDRON

Comparing quantitative prediction methods for the discovery of small-molecule chiral catalysts

(2018) Jolene P. Reid et al.   Nature Reviews Chemistry

Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities

(2017) Kyle A. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki–Miyaura Coupling

(2017) Beryl X. Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Origins of Ligand-Controlled Stereoselectivity of Ni-Catalyzed Suzuki–Miyaura Coupling with Benzylic Esters: A Computational Study

(2017) Shuo-Qing Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects

(2017) Kevin Wu et al.   Nature Chemistry

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach

(2017) Ngiap-Kie Lim et al.   ORGANIC LETTERS

Divergent Synthetic Access toE- andZ-Stereodefined All-Carbon-Substituted Olefin Scaffolds: Application to Parallel Synthesis of (E)- and (Z)-Tamoxifens

(2017) Yuichiro Ashida et al.   ChemistryOpen

The Development of Multidimensional Analysis Tools for Asymmetric Catalysis and Beyond

(2016) Matthew S. Sigman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Iron-Catalyzed Stereoselective Cross-Coupling Reactions of Stereodefined Enol Carbamates with Grignard Reagents

(2016) Ana Cristina Parra Rivera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper mediated carbometalation reactions

(2016) D. S. Müller et al.   CHEMICAL SOCIETY REVIEWS

Nickel-catalyzed Ring-opening Cross-coupling of Cyclic Alkenyl Ethers with Arylboronic Esters via Carbon–Oxygen Bond Cleavage

(2016) Akimichi Ohtsuki et al.   CHEMISTRY LETTERS

Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates

(2016) Melodie Christensen et al.   JOURNAL OF ORGANIC CHEMISTRY

Dinuclear Systems in the Efficient Nickel-Catalyzed Kumada–Tamao–Corriu Cross-Coupling of Aryl Halides

(2016) Kouki Matsubara et al.   ORGANOMETALLICS

Principal component analysis: a review and recent developments

(2016) Ian T. Jolliffe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Recent progress in transition metal-catalyzed stereoselective synthesis of acyclic all-carbon tetrasubstituted alkenes

(2016) Peter Polák et al.   TETRAHEDRON LETTERS

Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches

(2015) Lutz F. Tietze et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

(2015) Andiliy Lai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preparation of Tetrasubstituted Olefins Using Mono or Double Aerobic Direct C–H Functionalization Strategies: Importance of Steric Effects

(2015) Nicolas Gigant et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Highly Functionalized Tri- and Tetrasubstituted Alkenes via Pd-Catalyzed 1,2-Hydrovinylation of Terminal 1,3-Dienes

(2015) Vaneet Saini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic, Asymmetric, and Stereodivergent Synthesis of Non-Symmetric β,β-Diaryl-α-Amino Acids

(2015) Carmela Molinaro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular and Highly Stereoselective Approach to All-Carbon Tetrasubstituted Alkenes

(2015) Vladislav Kotek et al.   ORGANIC LETTERS

Recent advances in homogeneous nickel catalysis

(2014) Sarah Z. Tasker et al.   NATURE

Nickel Hydroxo Complexes as Intermediates in Nickel-Catalyzed Suzuki–Miyaura Cross-Coupling

(2014) Alec H. Christian et al.   ORGANOMETALLICS

Oxidative Heck Coupling of Allylic Amines with 2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) as Oxidant for the Preparation of Tetrasubstituted Alkenes

(2013) Zhiheng He et al.   ADVANCED SYNTHESIS & CATALYSIS

Enlarged tetrasubstituted alkenes with enhanced thermal and optoelectronic properties

(2013) Yang Liu et al.   CHEMICAL COMMUNICATIONS

Transition-metal-catalyzed Suzuki–Miyaura cross-coupling reactions: a remarkable advance from palladium to nickel catalysts

(2013) Fu-She Han   CHEMICAL SOCIETY REVIEWS

Selection of boron reagents for Suzuki–Miyaura coupling

(2013) Alastair J. J. Lennox et al.   CHEMICAL SOCIETY REVIEWS

Using Physical Organic Parameters To Correlate Asymmetric Catalyst Performance

(2013) Kaid C. Harper et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed, Chelation-Assisted Stereo- and Regioselective Synthesis of Tetrasubstituted Olefins by Oxidative Heck Arylation

(2012) Hyun Seung Lee et al.   ADVANCED SYNTHESIS & CATALYSIS

Oxidative Heck Arylation for the Stereoselective Synthesis of Tetrasubstituted Olefins Using Nitroxides as Oxidants

(2012) Zhiheng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand Effects on the Stereochemical Outcome of Suzuki–Miyaura Couplings

(2012) Guo-Ping Lu et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-catalyzed arylation of α,β-unsaturated Weinreb amides

(2012) Ko Hoon Kim et al.   TETRAHEDRON LETTERS

Synthesis and Photochemical Investigations of Tetrasubstituted Alkenes as Molecular Switches-The Effect of Substituents

(2011) Lutz F. Tietze et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand Effects on Negishi Couplings of Alkenyl Halides

(2011) Arkady Krasovskiy et al.   ORGANIC LETTERS

Percent buried volume for phosphine and N-heterocyclic carbene ligands: steric properties in organometallic chemistry

(2010) Hervé Clavier et al.   CHEMICAL COMMUNICATIONS

Estrogen Receptors: Therapies Targeted to Receptor Subtypes

(2010) S Nilsson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Stereoselective Negishi-like Couplings Between Alkenyl and Alkyl Halides in Water at Room Temperature

(2010) Arkady Krasovskiy et al.   ORGANIC LETTERS

SambVca: A Web Application for the Calculation of the Buried Volume of N-Heterocyclic Carbene Ligands

(2009) Albert Poater et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Mechanism of Ni-Catalyzed Selective C−O Bond Activation in Cross-Coupling of Aryl Esters

(2009) Zhe Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Coupling Reaction of Alkenyl Methyl Ethers with Aryl Boronic Esters

(2009) Toshiaki Shimasaki et al.   ORGANIC LETTERS

Tamoxifen: Catalyst for the change to targeted therapy

(2007) V. Craig Jordan   EUROPEAN JOURNAL OF CANCER