Molecular Imaging of Labile Heme in Living Cells Using a Small Molecule Fluorescent Probe

Learning from Artemisinin: Bioinspired Design of a Reaction-Based Fluorescent Probe for the Selective Sensing of Labile Heme in Complex Biosystems

(2020) Shuai Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

(2020) Samantha A. Swenson et al.   Cells

Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability

(2020) Santi Mestre-Fos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

(2020) Giacomo Canesin et al.   Cell Reports

High-Throughput Screening for the Discovery of Iron Homeostasis Modulators Using an Extremely Sensitive Fluorescent Probe

(2020) Tasuku Hirayama et al.   ACS Sensors

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

(2019) Mena Abdel-Nour et al.   SCIENCE

Heme binding to human CLOCK affects interactions with the E-box

(2019) Samuel L. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme and hemolysis in innate immunity: adding insult to injury

(2018) Rui Martins et al.   CURRENT OPINION IN IMMUNOLOGY

Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

(2018) Elizabeth A. Sweeny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Handling heme: The mechanisms underlying the movement of heme within and between cells

(2018) Rebecca K. Donegan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes

(2018) Tasuku Hirayama et al.   Metallomics

Circadian clock disruption by selective removal of endogenous carbon monoxide

(2018) Saika Minegishi et al.   Scientific Reports

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy

(2017) Lei Shi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical tools for detecting Fe ions

(2017) Tasuku Hirayama et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Quantification of labile heme in live malaria parasites using a genetically encoded biosensor

(2017) James R. Abshire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

(2017) Tasuku Hirayama et al.   Chemical Science

Macrophages and Iron Metabolism

(2016) Miguel P. Soares et al.   IMMUNITY

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

(2016) Rui Martins et al.   NATURE IMMUNOLOGY

Regulation of intracellular heme trafficking revealed by subcellular reporters

(2016) Xiaojing Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

(2016) David A. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

(2016) Deborah Chiabrando et al.   PLoS Genetics

A Genetically Encoded FRET Sensor for Intracellular Heme

(2015) Yanqun Song et al.   ACS Chemical Biology

Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage

(2015) Taka-aki Takeda et al.   Scientific Reports

Measurement of Heme Synthesis Levels in Mammalian Cells

(2015) Jagmohan Hooda et al.   Jove-Journal of Visualized Experiments

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

In Vitro Assembly of Catalase

(2014) Michael Baureder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCG2 regulates the pattern of self-renewing divisions in cisplatin-resistant non-small cell lung cancer cell lines

(2014) YING TANG et al.   ONCOLOGY REPORTS

A new class of high-contrast Fe(ii) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin

(2014) Masato Niwa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phagocytic Uptake of Oxidized Heme Polymer Is Highly Cytotoxic to Macrophages

(2014) Rohitas Deshmukh et al.   PLoS One

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

The porphyrias: advances in diagnosis and treatment

(2012) M. Balwani et al.   BLOOD

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

(2012) Hirotsugu Kobuchi et al.   PLoS One

A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells

(2012) Tasuku Hirayama et al.   Chemical Science

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif

(2010) Haruto Ishikawa et al.   BIOCHEMISTRY

Free Heme and the Polymerization of Sickle Cell Hemoglobin

(2010) Veselina V. Uzunova et al.   BIOPHYSICAL JOURNAL

Iron and Porphyrin Trafficking in Heme Biogenesis

(2010) Iman J. Schultz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Construction of a Library of Rhodol Fluorophores for Developing New Fluorescent Probes

(2010) Tao Peng et al.   ORGANIC LETTERS

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

(2010) R. Chakravarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2

(2009) Chun-ling Dai et al.   CANCER LETTERS

Suppression of ABCG2 inhibits cancer cell proliferation

(2009) Zhong Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

(2008) Dominika Nowis et al.   BMC CANCER

Analysis of heme-reconstitution of apoenzymes by means of surface plasmon resonance

(2008) Ljiljana Fruk et al.   CHEMICAL COMMUNICATIONS

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM