Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors

(2021) Sumeda Nandadasa et al.   MATRIX BIOLOGY

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

(2021) Salvatore Santamaria et al.   Scientific Reports

Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

(2020) Courtney C. Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components

(2020) Daniel R. Martin et al.   JCI Insight

ADAMTS proteases in cardiovascular physiology and disease

(2020) Salvatore Santamaria et al.   Open Biology

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

(2019) Sumeda Nandadasa et al.   Nature Communications

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7

(2019) Alain Colige et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis

(2019) Salvatore Santamaria et al.   Scientific Reports

Accumulation of versican facilitates wound healing: Implication of its initial ADAMTS-cleavage site

(2019) Shamima Islam et al.   MATRIX BIOLOGY

Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix RemodelingHighlights

(2018) Marika Fava et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ADAMTS9-Regulated Pericellular Matrix Dynamics Governs Focal Adhesion-Dependent Smooth Muscle Differentiation

(2018) Timothy J. Mead et al.   Cell Reports

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Expanding the chondroitin glycoproteome ofCaenorhabditis elegans

(2017) Fredrik Noborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma

(2017) Ndeye-Aicha Gueye et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

(2017) Keiichi Asano et al.   Scientific Reports

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment

(2016) C. Hope et al.   BLOOD

Benchmarking quantitative label-free LC–MS data processing workflows using a complex spiked proteomic standard dataset

(2016) Claire Ramus et al.   Journal of Proteomics

TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors

(2016) Anna Prudova et al.   Cell Reports

ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity

(2016) Meagan McMahon et al.   PLOS BIOLOGY

Activation of Mouse Cumulus-Oocyte Complex Maturation In Vitro Through EGF-Like Activity of Versican1

(2015) Kylie R. Dunning et al.   BIOLOGY OF REPRODUCTION

Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth

(2015) Kanda Fanhchaksai et al.   INTERNATIONAL JOURNAL OF CANCER

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics

(2015) Johanne Dubail et al.   MATRIX BIOLOGY

Versican V1 Overexpression Induces a Myofibroblast-Like Phenotype in Cultured Fibroblasts

(2015) Jon M. Carthy et al.   PLoS One

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation

(2015) Sumeda Nandadasa et al.   Cell Reports

Characterizing Protease Specificity: How Many Substrates Do We Need?

(2015) Michael Schauperl et al.   PLoS One

TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage

(2014) A. Prudova et al.   BLOOD

A newAdamts9conditional mouse allele identifies its non-redundant role in interdigital web regression

(2014) Johanne Dubail et al.   GENESIS

Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5

(2014) Simon J. Foulcer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis

(2014) Sumeda Nandadasa et al.   MATRIX BIOLOGY

Biosynthesis and Expression of a Disintegrin-like and Metalloproteinase Domain with Thrombospondin-1 Repeats-15

(2013) Carolyn M. Dancevic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves

(2013) Loren E. Dupuis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

(2012) D. Gao et al.   CANCER RESEARCH

Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development

(2012) Sonoko Hatano et al.   GLYCOBIOLOGY

Novel Role of ADAMTS-5 Protein in Proteoglycan Turnover and Lipoprotein Retention in Atherosclerosis

(2012) Athanasios Didangelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered versican cleavage in ADAMTS5 deficient mice; A novel etiology of myxomatous valve disease

(2011) Loren E. Dupuis et al.   DEVELOPMENTAL BIOLOGY

ADAMTS1 Cleavage of Versican Mediates Essential Structural Remodeling of the Ovarian Follicle and Cumulus-Oocyte Matrix During Ovulation in Mice1

(2010) Hannah M. Brown et al.   BIOLOGY OF REPRODUCTION

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation

(2010) H. Enomoto et al.   DEVELOPMENT

Versican Facilitates Chondrocyte Differentiation and Regulates Joint Morphogenesis

(2010) Kanyamas Choocheep et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies

(2010) Christine B. Kern et al.   MATRIX BIOLOGY

Broad Coverage Identification of Multiple Proteolytic Cleavage Site Sequences in Complex High Molecular Weight Proteins Using Quantitative Proteomics as a Complement to Edman Sequencing

(2010) Alain Doucet et al.   MOLECULAR & CELLULAR PROTEOMICS

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression

(2009) Daniel R. McCulloch et al.   DEVELOPMENTAL CELL

Versican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting

(2009) Philippe Kischel et al.   INTERNATIONAL JOURNAL OF CANCER

Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts

(2009) Keittisak Suwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS

(2009) M. T. Dours-Zimmermann et al.   JOURNAL OF NEUROSCIENCE

Characterization of proADAMTS5 processing by proprotein convertases

(2008) Jean-Michel Longpré et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion

(2008) Juan Carlos Rodríguez-Manzaneque et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival

(2008) Debra L. Silver et al.   PLoS Genetics

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

(2007) Lidia Mosyak et al.   PROTEIN SCIENCE