Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture

Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules

(2020) Jesse Yu et al.   PHARMACEUTICAL RESEARCH

Bictegravir Plus Tenofovir Alafenamide Nanoformulation as a Long-Acting Pre-Exposure Prophylaxis Regimen: Application of Modeling to Design Non-Human Primate Pharmacokinetic Experiments

(2020) Simone Perazzolo et al.   Frontiers in Pharmacology

Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective

(2020) Simone Perazzolo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Renal Lymphatics: Anatomy, Physiology, and Clinical Implications

(2019) Peter Spencer Russell et al.   Frontiers in Physiology

Antiretroviral drug concentrations in lymph nodes: a cross-species comparison of the effect of drug transporter expression, viral infection, and sex in humanized mice, nonhuman primates, and humans

(2019) Erin Burgunder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High-resolution 3D imaging and topological mapping of the lymph node conduit system

(2019) Inken D. Kelch et al.   PLOS BIOLOGY

Combating the HIV reservoirs

(2018) Guido van Marle et al.   Biotechnology & Genetic Engineering Reviews

Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation

(2018) John C. Kraft et al.   JOURNAL OF CONTROLLED RELEASE

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

(2015) Katherine L. Gill et al.   AAPS Journal

Anti-HIV Drug-Combination Nanoparticles Enhance Plasma Drug Exposure Duration as Well as Triple-Drug Combination Levels in Cells Within Lymph Nodes and Blood in Primates

(2015) Jennifer P. Freeling et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Detection of Anti-HIV Drugs Lopinavir, Ritonavir, and Tenofovir in Plasma

(2014) J. Koehn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lymph Node Count at Inguinofemoral Lymphadenectomy and Groin Recurrences in Vulvar Cancer

(2014) Heleen J. van Beekhuizen et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism

(2014) Vitaly V. Ganusov et al.   PLoS Computational Biology

The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

(2013) Annette M. Dahlberg et al.   MOLECULAR PHARMACEUTICS

Compared to Subcutaneous Tenofovir, Oral Tenofovir Disoproxyl Fumarate Administration Preferentially Concentrates the Drug into Gut-Associated Lymphoid Cells in Simian Immunodeficiency Virus-Infected Macaques

(2012) Koen K. A. Van Rompay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dermal Clearance Model for Epidermal Bioavailability Calculations

(2012) Rania Ibrahim et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

(2011) B. J. Kirby et al.   DRUG METABOLISM AND DISPOSITION

Quantitative Analyses of Lymphoid Tissue in the Spleen, Lymph Nodes and Peyer's Patches in Cynomolgus Monkeys

(2011) Akiko MORIYAMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes

(2010) O. Janneh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection

(2010) P. L. Anderson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lymph Flow In Instrumented Dogs Varies With Exercise Intensity

(2010) Pratikkumar Desai et al.   Lymphatic Research and Biology

Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography

(2009) M. Di Mascio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nucleotide Analogue Prodrug Tenofovir Disoproxil Enhances Lymphoid Cell Loading following Oral Administration in Monkeys

(2009) Lucie Durand-Gasselin et al.   MOLECULAR PHARMACEUTICS

The role of secondary lymphatic tissue in immune deficiency of HIV infection

(2008) Timothy Schacker   AIDS

Lymph Circulation in the Liver

(2008) Osamu Ohtani et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology