Process Analytical Technologies – Advances in bioprocess integration and future perspectives

Production of high‐quality SARS‐CoV‐2 antigens: impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance

(2021) Rute Castro et al.   BIOTECHNOLOGY AND BIOENGINEERING

A genome‐scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures

(2021) Song‐Min Schinn et al.   BIOTECHNOLOGY AND BIOENGINEERING

Monitoring E. coli Cell Integrity by ATR-FTIR Spectroscopy and Chemometrics: Opportunities and Caveats

(2021) Jens Kastenhofer et al.   Processes

Process Analytical Technology for Precipitation Process Integration into Biologics Manufacturing towards Autonomous Operation—mAb Case Study

(2021) Lara Julia Lohmann et al.   Processes

Viable cell density on-line auto-control in perfusion cell culture aided by in-situ Raman spectroscopy

(2021) Gong Chen et al.   BIOCHEMICAL ENGINEERING JOURNAL

How to draw the line – Raman spectroscopy as a tool for the assessment of biomedicines

(2021) Christel Kamp et al.   BIOLOGICAL CHEMISTRY

PAT solutions to monitor adsorption of Tetanus Toxoid with aluminum adjuvants

(2021) Manjit Haer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Digital Twin of mRNA-Based SARS-COVID-19 Vaccine Manufacturing towards Autonomous Operation for Improvements in Speed, Scale, Robustness, Flexibility and Real-Time Release Testing

(2021) Axel Schmidt et al.   Processes

Moving towards an era of hybrid modelling: advantages and challenges of coupling mechanistic and data-driven models for upstream pharmaceutical bioprocesses

(2021) Apostolos Tsopanoglou et al.   Current Opinion in Chemical Engineering

Current and future requirements to industrial analytical infrastructure—part 2: smart sensors

(2020) Tobias Eifert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quality assurance at the point-of-care: Noninvasively detecting vaccine freezing variability using water proton NMR

(2020) Katharine T. Briggs et al.   VACCINE

Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review

(2020) Dhanuka P. Wasalathanthri et al.   BIOTECHNOLOGY AND BIOENGINEERING

Real Time Monitoring of Quality Attributes by In‐line Fourier Transform Infrared Spectroscopic Sensors at Ultrafiltration and Diafiltration of Bioprocess

(2020) Dhanuka P. Wasalathanthri et al.   BIOTECHNOLOGY AND BIOENGINEERING

Analysis of Transformed Upstream Bioprocess Data Provides Insights into Biological System Variation

(2020) Anne Richelle et al.   Biotechnology Journal

Enzyme capacity-based genome scale modelling of CHO cells

(2020) Hock Chuan Yeo et al.   METABOLIC ENGINEERING

Using benchtop NMR spectroscopy as an online non-invasive in vivo lipid sensor for microalgae cultivated in photobioreactors

(2020) Dylan Bouillaud et al.   PROCESS BIOCHEMISTRY

An Artificial Neural Network Assisted Dynamic Light Scattering Procedure for Assessing Living Cells Size in Suspension

(2020) Dan Chicea   SENSORS

Towards a Digital Bioprocess Replica: Computational Approaches in Biopharmaceutical Development and Manufacturing

(2020) Jens Smiatek et al.   TRENDS IN BIOTECHNOLOGY

Monitoring of the sedimentation kinetics of vaccine adjuvants using water proton NMR relaxation

(2020) Marc B. Taraban et al.   MAGNETIC RESONANCE IN CHEMISTRY

Digital Twins in Pharmaceutical and Biopharmaceutical Manufacturing: A Literature Review

(2020) Yingjie Chen et al.   Processes

Raman Spectroscopy as Process Analytical Tool in Downstream Processing of Biotechnology

(2020) Yu Kiat Lin et al.   CHINESE JOURNAL OF CHEMICAL ENGINEERING

Real-time bioprocess monitoring using a mid-infrared fibre-optic sensor

(2020) Farah Alimagham et al.   BIOCHEMICAL ENGINEERING JOURNAL

Kinetics of Asymmetric Transfer Hydrogenation, Catalyst Deactivation, and Inhibition with Noyori Complexes As Revealed by Real-Time High-Resolution FlowNMR Spectroscopy

(2019) Andrew M. R. Hall et al.   ACS Catalysis

Flexible automation with compact NMR spectroscopy for continuous production of pharmaceuticals

(2019) Simon Kern et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The application of process analytical technologies (PAT) to the dairy industry for real time product characterization - process viscometry

(2019) Norah O'Shea et al.   Innovative Food Science & Emerging Technologies

Data science tools and applications on the way to Pharma 4.0

(2019) Valentin Steinwandter et al.   DRUG DISCOVERY TODAY

Automatic real‐time calibration, assessment, and maintenance of generic Raman models for online monitoring of cell culture processes

(2019) Aditya Tulsyan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Real-time benchtop NMR spectroscopy for the online monitoring of sucrose hydrolysis

(2019) Alper Soyler et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Role of raw materials in biopharmaceutical manufacturing: risk analysis and fingerprinting

(2018) Anurag S Rathore et al.   CURRENT OPINION IN BIOTECHNOLOGY

27 Al and 31 P NMR spectroscopy method development to quantify aluminum phosphate in adjuvanted vaccine formulations

(2018) Rahima Khatun et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Raman spectroscopy-based identification of toxoid vaccine products

(2018) Anja Silge et al.   npj Vaccines

Benchtop NMR for the monitoring of bioprocesses

(2018) Dylan Bouillaud et al.   MAGNETIC RESONANCE IN CHEMISTRY

In-line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

(2017) Hemlata Bhatia et al.   ENGINEERING IN LIFE SCIENCES

On-line prediction of the glucose concentration of CHO cell cultivations by NIR and Raman spectroscopy: Comparative scalability test with a shake flask model system

(2017) Bence Kozma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Real-time product release and process control challenges in the dairy milk powder industry

(2017) Muhammad Tajammal Munir et al.   Current Opinion in Food Science

Spectroscopic sensors for in-line bioprocess monitoring in research and pharmaceutical industrial application

(2016) Jens Claßen et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Online monitoring of fermentation processes via non-invasive low-field NMR

(2015) Dirk Kreyenschulte et al.   BIOTECHNOLOGY AND BIOENGINEERING

Sensor systems for bioprocess monitoring

(2015) Philipp Biechele et al.   ENGINEERING IN LIFE SCIENCES

Reaction monitoring using online vs tube NMR spectroscopy: seriously different results

(2015) David A. Foley et al.   MAGNETIC RESONANCE IN CHEMISTRY

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

(2015) Levente L. Simon et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

NMR Flow Tube for Online NMR Reaction Monitoring

(2014) David A. Foley et al.   ANALYTICAL CHEMISTRY

Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: Prediction of multiple cultivation variables

(2013) Matthieu Clavaud et al.   TALANTA

Bioreactor monitoring with spectroscopy and chemometrics: a review

(2012) N. D. Lourenço et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

(2010) T. De Beer et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Process Development of Ravuconazole: An Efficient Multikilogram Scale Preparation of an Antifungal Agent(1)

(2009) Jaan Pesti et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine

(2008) Amber L. Clausi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibition of Aggregation of Aluminum Hydroxide Adjuvant During Freezing and Drying

(2007) Amber L. Clausi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES