Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth

Angiocrine endothelium: from physiology to cancer

(2020) Jennifer Pasquier et al.   Journal of Translational Medicine

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease

(2019) Francesco Borriello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861

(2019) Ana-Rita Pedrosa et al.   CANCER RESEARCH

Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis

(2019) Mahak Singhal et al.   CANCER RESEARCH

Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer

(2019) David E. Gerber et al.   LUNG CANCER

Crucial biological functions of CCL7 in cancer

(2018) Yangyang Liu et al.   PeerJ

Heat Shock Proteins as Immunomodulants

(2018) Tawanda Zininga et al.   MOLECULES

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice

(2017) Annika N Alexopoulou et al.   JOURNAL OF PATHOLOGY

Complement factor H in host defense and immune evasion

(2016) Raffaella Parente et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

(2016) Barbara Bottazzi et al.   JOURNAL OF HEPATOLOGY

Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage

(2016) Irina Ushach et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Fluorescence properties of several chemotherapy drugs: doxorubicin, paclitaxel and bleomycin

(2016) Najme Sadat Hosseini Motlagh et al.   Biomedical Optics Express

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

(2015) Suzanne F. Jones et al.   INVESTIGATIONAL NEW DRUGS

Mechanism of Focal Adhesion Kinase Mechanosensing

(2015) Jing Zhou et al.   PLoS Computational Biology

Emerging Roles of Focal Adhesion Kinase in Cancer

(2015) Yu-Ling Tai et al.   Biomed Research International

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer

(2014) Annika N Alexopoulou et al.   BMC CANCER

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

Generation of point-mutant FAK knockin mice

(2014) B. Tavora et al.   GENESIS

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Understanding the Roles of FAK in Cancer

(2014) Hyunho Yoon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

(2014) Bernardo Tavora et al.   NATURE

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

(2013) Tracy Thennes Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

(2013) M. Luo et al.   CANCER RESEARCH

pHocal adhesion kinase regulation is on a FERM foundation

(2013) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Off-targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies usingFak-deficient mice

(2013) M. E. Roh et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

FAK-heterozygous mice display enhanced tumour angiogenesis

(2013) Vassiliki Kostourou et al.   Nature Communications

Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

(2012) Alexander Schultze et al.   Anti-Cancer Agents in Medicinal Chemistry

Development of Focal Adhesion Kinase Inhibitors in Cancer Therapy

(2012) Wen Wee Ma   Anti-Cancer Agents in Medicinal Chemistry

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Focal Adhesion Kinase as a Cancer Therapy Target

(2011) Vita M. Golubovskaya   Anti-Cancer Agents in Medicinal Chemistry

Focal adhesion kinase and tumour angiogenesis

(2011) Tanguy Lechertier et al.   JOURNAL OF PATHOLOGY

Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood-Brain Barrier in Glioma

(2010) J. Lee et al.   CANCER RESEARCH

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

(2010) Ssang-Taek Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

(2010) Xiaofeng Zhao et al.   JOURNAL OF CELL BIOLOGY

A Self-validating Quantitative Mass Spectrometry Method for Assessing the Accuracy of High-content Phosphoproteomic Experiments

(2010) Pedro Casado et al.   MOLECULAR & CELLULAR PROTEOMICS

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Role for lysosomal enzyme -hexosaminidase in the control of mycobacteria infection

(2008) I. C. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA