Formononetin represses cervical tumorigenesis by interfering with the activation of PD-L1 through MYC and STAT3 downregulation

P2X7 receptor‐targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk

(2020) Yu Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer

(2020) Zhi Hong Zhang et al.   PHYTOMEDICINE

Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells

(2020) Zhe Wang et al.   PHARMACOLOGICAL RESEARCH

A Review of the Pharmacological Action of Astragalus Polysaccharide

(2020) Yijun Zheng et al.   Frontiers in Pharmacology

Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1α and STAT3 (T705) signaling pathways in hepatic cancer

(2020) Hong Xiang Zuo et al.   JOURNAL OF ETHNOPHARMACOLOGY

PD-1/PD-L1 Inhibitors in Cervical Cancer

(2019) Yuncong Liu et al.   Frontiers in Pharmacology

PD-L1 promotes colorectal cancer stem cell expansion by activating HMGA1-dependent signaling pathways

(2019) Fang Wei et al.   CANCER LETTERS

Musashi-1 Enhances Glioblastoma Migration by Promoting ICAM1 Translation

(2019) Jang-Chun Lin et al.   NEOPLASIA

Focus on Formononetin: Anticancer Potential and Molecular Targets

(2019) Ong et al.   Cancers

Formononetin: A Review of Its Anticancer Potentials and Mechanisms

(2019) Kai-Ching Tay et al.   Frontiers in Pharmacology

Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner

(2019) Xin Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cisplatin increases PD-L1 expression and optimizes immune check-point blockade in non-small cell lung cancer

(2019) Ludovic Fournel et al.   CANCER LETTERS

Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma

(2019) D Schulz et al.   CARCINOGENESIS

Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: Modulation of oxidative stress and inflammation

(2019) Minglong Xin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis

(2018) Xia Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cervical cancer – State of the science: From angiogenesis blockade to checkpoint inhibition

(2018) Lindsey E. Minion et al.   GYNECOLOGIC ONCOLOGY

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment

(2018) Federica Laudisi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways

(2018) Jing Ying Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3

(2018) Yue Xing et al.   PHARMACOLOGICAL RESEARCH

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

(2018) Huanbin Wang et al.   Nature Chemical Biology

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

(2018) Benny Zhitomirsky et al.   Cell Death & Disease

PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation

(2017) Sheema Almozyan et al.   INTERNATIONAL JOURNAL OF CANCER

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma

(2017) V Atsaves et al.   LEUKEMIA

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Chelidonine inhibits TNF-α-induced inflammation by suppressing the NF-κB pathways in HCT116 cells

(2017) Zhi Hong Zhang et al.   PHYTOTHERAPY RESEARCH

Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma

(2017) Song Xue et al.   Oncotarget

Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators

(2017) Yong Qin et al.   Frontiers in Immunology

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

(2016) MoonSun Jung et al.   CANCER RESEARCH

STAT3 signaling in immunity

(2016) Emily J. Hillmer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers

(2016) Kaiming Sun et al.   MOLECULAR CANCER THERAPEUTICS

Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway

(2016) Ting Bai et al.   PHARMACOLOGICAL RESEARCH

Protein breakdown in cancer cachexia

(2016) Marco Sandri   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Worldwide trends in cervical cancer incidence: Impact of screening against changes in disease risk factors

(2013) Salvatore Vaccarella et al.   EUROPEAN JOURNAL OF CANCER

Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia

(2013) Wen Yang et al.   IMMUNOLOGY

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis

(2013) Bernd H. Zinselmeyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

B7-H1, Which Represses EBV-Immortalized B Cell Killing by Autologous T and NK Cells, Is Oppositely Regulated by c-Myc and EBV Latency III Program at Both mRNA and Secretory Lysosome Levels

(2012) S. Durand-Panteix et al.   JOURNAL OF IMMUNOLOGY

EGFR Promotes Lung Tumorigenesis by Activating miR-7 through a Ras/ERK/Myc Pathway That Targets the Ets2 Transcriptional Repressor ERF

(2010) Y.-T. Chou et al.   CANCER RESEARCH