Engineering the aortic valve extracellular matrix through stages of development, aging, and disease

Extracellular Matrix in Calcific Aortic Valve Disease: Architecture, Dynamic and Perspectives

(2021) Anna Di Vito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Collagen fiber regulation in human pediatric aortic valve development and disease

(2021) Cassandra L. Clift et al.   Scientific Reports

Elastin-Like Polypeptides for Biomedical Applications

(2020) Anastasia K. Varanko et al.   Annual Review of Biomedical Engineering

Age, Sex, and Valve Phenotype Differences in Fibro‐Calcific Remodeling of Calcified Aortic Valve

(2020) Martine Voisine et al.   Journal of the American Heart Association

Which Biological Properties of Heart Valves Are Relevant to Tissue Engineering?

(2020) Adrian H. Chester et al.   Frontiers in Cardiovascular Medicine

Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization

(2020) Megan E. Schroeder et al.   Acta Biomaterialia

Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve

(2020) Letitia Ciortan et al.   Polymers

Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery

(2019) Sonia Trombino et al.   Pharmaceutics

Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step

(2019) Marleen Kristen et al.   Advanced Healthcare Materials

Advanced glycation end-products regulate extracellular matrix-adipocyte metabolic crosstalk in diabetes

(2019) Clarissa Strieder-Barboza et al.   Scientific Reports

Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics

(2018) Dewy van der Valk et al.   Nanomaterials

Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease

(2018) Kyoung Im Cho et al.   ATHEROSCLEROSIS

Exogenous Lysyl Oxidase-Like 2 and Perfusion Culture Induce Collagen Crosslink Formation in Osteogenic Grafts

(2018) Debika Mitra et al.   Biotechnology Journal

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP 5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

(2018) Wanda Anselmo et al.   Journal of the American Heart Association

Behavior of valvular interstitial cells on trilayered nanofibrous substrate mimicking morphologies of heart valve leaflet

(2018) Soumen Jana et al.   Acta Biomaterialia

Dysregulation of hyaluronan homeostasis during aortic valve disease

(2017) Varun K. Krishnamurthy et al.   MATRIX BIOLOGY

Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease

(2017) Ana M. Porras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures

(2017) Ana M. Porras et al.   Journal of the American Heart Association

Age-dependent changes of stress and strain in the human heart valve and their relation with collagen remodeling

(2016) P.J.A. Oomen et al.   Acta Biomaterialia

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

(2016) Jina Lim et al.   AMERICAN JOURNAL OF PATHOLOGY

Cells and extracellular matrix interplay in cardiac valve disease: because age matters

(2016) Cristiano Spadaccio et al.   BASIC RESEARCH IN CARDIOLOGY

Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds

(2016) Daniel S. Puperi et al.   BIOMACROMOLECULES

Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype

(2016) Kelly M. Mabry et al.   BIOMATERIALS

Adhesive Peptide Sequences Regulate Valve Interstitial Cell Adhesion, Phenotype and Extracellular Matrix Deposition

(2016) Yan Wu et al.   Cellular and Molecular Bioengineering

Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic StenosisNovelty and Significance

(2016) Louis Simard et al.   CIRCULATION RESEARCH

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation

(2016) Jesper Hjortnaes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

(2016) Daniela Loessner et al.   Nature Protocols

Calcific aortic stenosis

(2016) Brian R. Lindman et al.   Nature Reviews Disease Primers

Age-Dependent Changes in Geometry, Tissue Composition and Mechanical Properties of Fetal to Adult Cryopreserved Human Heart Valves

(2016) Daphne van Geemen et al.   PLoS One

Calcific Aortic Valve Disease Is Associated with Layer-Specific Alterations in Collagen Architecture

(2016) Heather N. Hutson et al.   PLoS One

Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering

(2015) Xing Zhang et al.   Acta Biomaterialia

3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model

(2015) Daniel S. Puperi et al.   BIOMATERIALS

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

The lipid theory in the pathogenesis of calcific aortic stenosis

(2015) V. Parisi et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology

(2015) Ana M. Porras et al.   Journal of the American Heart Association

Tri-layered elastomeric scaffolds for engineering heart valve leaflets

(2014) Nafiseh Masoumi et al.   BIOMATERIALS

Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification

(2014) Karien J Rodriguez et al.   BMC Cardiovascular Disorders

Evaluation of a porcine model of early aortic valve sclerosis

(2014) Krista L. Sider et al.   CARDIOVASCULAR PATHOLOGY

Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering

(2014) Maryam Eslami et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

The Prevalence, Incidence, Progression, and Risks of Aortic Valve Sclerosis

(2014) Sean Coffey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Metabolic regulation of collagen gel contraction by porcine aortic valvular interstitial cells

(2014) P. I. Kamel et al.   Journal of the Royal Society Interface

Clickable, Photodegradable Hydrogels to Dynamically Modulate Valvular Interstitial Cell Phenotype

(2014) Chelsea M. Kirschner et al.   Advanced Healthcare Materials

Directing Valvular Interstitial Cell Myofibroblast-Like Differentiation in a Hybrid Hydrogel Platform

(2014) Jesper Hjortnaes et al.   Advanced Healthcare Materials

Electrospun PGS:PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy

(2014) Nafiseh Masoumi et al.   Advanced Healthcare Materials

Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels

(2013) Bin Duan et al.   Acta Biomaterialia

Age-Related Changes in Aortic Valve Hemostatic Protein Regulation

(2013) Liezl R. Balaoing et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of cell-matrix interactions on VIC phenotype and tissue deposition in 3D PEG hydrogels

(2013) Sarah T. Gould et al.   Journal of Tissue Engineering and Regenerative Medicine

A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions

(2013) Michelle B. Chen et al.   LAB ON A CHIP

Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

(2013) Sergio Bertazzo et al.   NATURE MATERIALS

Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture

(2012) Russell A. Gould et al.   Acta Biomaterialia

Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products

(2012) Fei Li et al.   BASIC RESEARCH IN CARDIOLOGY

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

Differential proteoglycan and hyaluronan distribution in calcified aortic valves

(2010) Elizabeth H. Stephens et al.   CARDIOVASCULAR PATHOLOGY

Regulation of valvular interstitial cell phenotype and function by hyaluronic acid in 2-D and 3-D culture environments

(2010) Karien J. Rodriguez et al.   MATRIX BIOLOGY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels

(2009) Julie A. Benton et al.   BIOMATERIALS

Heart Valve Development

(2009) Michelle D. Combs et al.   CIRCULATION RESEARCH

On the biomechanics of heart valve function

(2009) Michael S. Sacks et al.   JOURNAL OF BIOMECHANICS

Photocrosslinking of Gelatin Macromers to Synthesize Porous Hydrogels That Promote Valvular Interstitial Cell Function

(2009) Julie A. Benton et al.   TISSUE ENGINEERING PART A

Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve

(2008) Elizabeth H. Stephens et al.   Acta Biomaterialia

Efficacy of Simvastatin Treatment of Valvular Interstitial Cells Varies With the Extracellular Environment

(2008) Elyssa L. Monzack et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effect of bioactive hydrogels on the secretion of extracellular matrix molecules by valvular interstitial cells

(2008) Darshita N. Shah et al.   BIOMATERIALS

Regulation of valvular interstitial cell calcification by components of the extracellular matrix

(2008) Karien J. Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Influence of strain on proteoglycan synthesis by valvular interstitial cells in three-dimensional culture

(2007) Vishal Gupta et al.   Acta Biomaterialia