Cells and extracellular matrix interplay in cardiac valve disease: because age matters

Early aortic valve inflammation precedes calcification: A longitudinal FDG-PET/CT study

(2015) Amr Abdelbaky et al.   ATHEROSCLEROSIS

Osteopontin alters endothelial and valvular interstitial cell behaviour in calcific aortic valve stenosis through HMGB1 regulation

(2015) Margaret Passmore et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells

(2015) Vishal Patel et al.   FASEB JOURNAL

Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways

(2015) Qiong Zhan et al.   International Journal of Biological Sciences

Endothelial-Derived Oxidative Stress Drives Myofibroblastic Activation and Calcification of the Aortic Valve

(2015) Emily J. Farrar et al.   PLoS One

IL-10 Genetic Polymorphisms Were Associated with Valvular Calcification in Han, Uygur and Kazak Populations in Xinjiang, China

(2015) Yong An et al.   PLoS One

HIF-1α and VEGF: Immunohistochemical Profile and Possible Function in Human Aortic Valve Stenosis

(2015) Ida Perrotta et al.   ULTRASTRUCTURAL PATHOLOGY

Successful re-endothelialization of a perfusable biological vascularized matrix (BioVaM) for the generation of 3D artificial cardiac tissue

(2014) Birgit Andrée et al.   BASIC RESEARCH IN CARDIOLOGY

Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression

(2014) Dong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RAGE influences the development of aortic valve stenosis in mice on a high fat diet

(2014) Britt Hofmann et al.   EXPERIMENTAL GERONTOLOGY

Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis

(2014) J. Gustav Smith et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aortic valve calcification is mediated by a differential response of aortic valve interstitial cells to inflammation

(2014) Neil Venardos et al.   JOURNAL OF SURGICAL RESEARCH

Reduction of Advanced-Glycation End Products Levels and Inhibition of RAGE Signaling Decreases Rat Vascular Calcification Induced by Diabetes

(2014) Mathieu R. Brodeur et al.   PLoS One

Synergy between Sphingosine 1-Phosphate and Lipopolysaccharide Signaling Promotes an Inflammatory, Angiogenic and Osteogenic Response in Human Aortic Valve Interstitial Cells

(2014) Isabel Fernández-Pisonero et al.   PLoS One

Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients

(2014) Pierre Delanaye et al.   BMC Nephrology

Genetics of Valvular Heart Disease

(2014) Stephanie LaHaye et al.   Current Cardiology Reports

Survival and Quality of Life for Nonagenarians After Cardiac Surgery

(2013) Manuel Caceres et al.   ANNALS OF THORACIC SURGERY

Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-κB Activation

(2013) Qingchun Zeng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Age-Related Changes in Aortic Valve Hemostatic Protein Regulation

(2013) Liezl R. Balaoing et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Age-related analysis of structural, biochemical and mechanical properties of the porcine mitral heart valve leaflets

(2013) Vladimir Kasyanov et al.   CONNECTIVE TISSUE RESEARCH

All anterior and bileaflet mitral valve prolapses are repairable in the modern era of reconstructive surgery

(2013) J. G. Castillo et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Comparative study of human aortic and mitral valve interstitial cell gene expression and cellular function

(2013) Wei Sun et al.   GENOMICS

Mitral Valve Enlargement in Chronic Aortic Regurgitation as a Compensatory Mechanism to Prevent Functional Mitral Regurgitation in the Dilated Left Ventricle

(2013) Jonathan Beaudoin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults

(2013) Carole L. Wilson et al.   MECHANISMS OF DEVELOPMENT

Genetic Associations with Valvular Calcification and Aortic Stenosis

(2013) George Thanassoulis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the Role of Fluid Shear Stress in the Expression of Early Signaling Markers for Calcific Aortic Valve Disease

(2013) Ling Sun et al.   PLoS One

Cardiac surgery in nonagenarians: not only feasible, but also reasonable?†

(2013) Alexander Assmann et al.   Interactive Cardiovascular and Thoracic Surgery

On the biomechanical role of glycosaminoglycans in the aortic heart valve leaflet

(2012) Chad E. Eckert et al.   Acta Biomaterialia

The new ESC/EACTS Guidelines on the management of valvular heart disease

(2012) Alec Vahanian et al.   Archives of Cardiovascular Diseases

Pioglitazone attenuates progression of aortic valve calcification via down-regulating receptor for advanced glycation end products

(2012) Fei Li et al.   BASIC RESEARCH IN CARDIOLOGY

The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops

(2012) Chen Li et al.   CARDIOVASCULAR PATHOLOGY

Advanced glycation end products and lipofuscin deposits share the same location in cardiocytes of the failing heart

(2012) Jerzy Nozynski et al.   EXPERIMENTAL GERONTOLOGY

Calpain-1 Regulation of Matrix Metalloproteinase 2 Activity in Vascular Smooth Muscle Cells Facilitates Age-Associated Aortic Wall Calcification and Fibrosis

(2012) Liqun Jiang et al.   HYPERTENSION

Inflammation Is Associated with the Remodeling of Calcific Aortic Valve Disease

(2012) Nancy Coté et al.   INFLAMMATION

Statin use for nonrheumatic calcific aortic valve stenosis

(2012) Renato De Vecchis et al.   Journal of Cardiovascular Medicine

Calcific Aortic Stenosis

(2012) Marc R. Dweck et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Multi-Scale Biomechanical Remodeling in Aging and Genetic Mutant Murine Mitral Valve Leaflets: Insights into Marfan Syndrome

(2012) Russell A. Gould et al.   PLoS One

Replication of Genetic Association Studies in Aortic Stenosis in Adults

(2011) Nathalie Gaudreault et al.   AMERICAN JOURNAL OF CARDIOLOGY

Cell–Matrix Interactions in the Pathobiology of Calcific Aortic Valve Disease

(2011) Jan-Hung Chen et al.   CIRCULATION RESEARCH

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

(2011) Jordan D. Miller et al.   CIRCULATION RESEARCH

First-in-man implantation of a Sorin Memo 3D ring: Mitral annular flexibility is still preserved at 5years of follow-up!

(2011) Giuseppe Santarpino et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Stenotic aortic valves have dysfunctional mechanisms of anti-inflammation: Implications for aortic stenosis

(2011) Joon H. Lee et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region

(2010) Elizabeth H. Stephens et al.   Acta Biomaterialia

Increased Biglycan in Aortic Valve Stenosis Leads to the Overexpression of Phospholipid Transfer Protein via Toll-Like Receptor 2

(2010) Habib Derbali et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner

(2010) Kartik Balachandran et al.   AMERICAN JOURNAL OF PATHOLOGY

Aortic valve disease and gamma-glutamyltransferase: Accumulation in tissue and relationships with calcific degeneration

(2010) Stefania Cappelli et al.   ATHEROSCLEROSIS

Circulating soluble receptor for advanced glycation end-product levels are decreased in patients with calcific aortic valve stenosis

(2010) Giuseppina Basta et al.   ATHEROSCLEROSIS

Differential proteoglycan and hyaluronan distribution in calcified aortic valves

(2010) Elizabeth H. Stephens et al.   CARDIOVASCULAR PATHOLOGY

Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis

(2010) Kwan Leung Chan et al.   CIRCULATION

Statins for Calcific Aortic Valve Stenosis: Into Oblivion After SALTIRE and SEAS? An Extensive Review from Bench to Bedside

(2010) Hadewich Hermans et al.   CURRENT PROBLEMS IN CARDIOLOGY

NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD)

(2010) Stella Marie Reamon-Buettner et al.   HUMAN MUTATION

Inhibition of Notch1 signaling by Runx2 during osteoblast differentiation

(2010) Eun-Jung Ann et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteopontin controls endothelial cell migration in vitro and in excised human valvular tissue from patients with calcific aortic stenosis and controls

(2010) Paolo Poggio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis

(2010) T. Ueland et al.   JOURNAL OF INTERNAL MEDICINE

Contribution of Bone Morphogenetic Protein-2 to Aortic Valve Calcification in Aged Rat

(2010) Kazuhiko Seya et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Associations of Long-Term and Early Adult Atherosclerosis Risk Factors With Aortic and Mitral Valve Calcium

(2010) George Thanassoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Pathogenesis and Treatment of the Valvulopathy of Aortic Stenosis: Beyond the SEAS

(2010) Sammy Elmariah et al.   Current Cardiology Reports

Identification and Characterization of Aortic Valve Mesenchymal Progenitor Cells with Robust Osteogenic Calcification Potential

(2009) Jan-Hung Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

(2009) Kartik Balachandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

(2009) Cindy Ying Yin Yip et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The regulation of tenascin expression by tissue microenvironments

(2009) Richard P. Tucker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells

(2009) Kathryn E. Smith et al.   Biomechanics and Modeling in Mechanobiology

The effects of cross-link density and chemistry on the calcification potential of diamine-extended glutaraldehyde-fixed bioprosthetic heart-valve materials

(2009) Deon Bezuidenhout et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

(2009) Elena Aikawa et al.   CIRCULATION

Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation

(2009) Troy Camarata et al.   DEVELOPMENTAL BIOLOGY

Wnt signaling in heart valve development and osteogenic gene induction

(2009) Christina M. Alfieri et al.   DEVELOPMENTAL BIOLOGY

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction

(2009) Pia R. Kamstrup   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mechano-potential etiologies of aortic valve disease

(2009) W. David Merryman   JOURNAL OF BIOMECHANICS

Pro-Osteogenic Phenotype of Human Aortic Valve Interstitial Cells Is Associated With Higher Levels of Toll-Like Receptors 2 and 4 and Enhanced Expression of Bone Morphogenetic Protein 2

(2009) Xiaoping Yang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aortic Valve Mechanics

(2009) Craig A. Simmons   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps

(2009) Ismail El-Hamamsy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

(2009) Robert Clarke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Changes in Material Behavior of Porcine Mitral and Aortic Valves and Correlation to Matrix Composition

(2009) Elizabeth H. Stephens et al.   TISSUE ENGINEERING PART A

Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical load and age: Relevance to an age-specific tissue-engineered heart valve

(2008) Elizabeth H. Stephens et al.   Acta Biomaterialia

Effect of cyclic mechanical strain on glycosaminoglycan and proteoglycan synthesis by heart valve cells

(2008) Vishal Gupta et al.   Acta Biomaterialia

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genomics

(2008) Yohan Bossé et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis

(2008) Anne B. Rossebø et al.   NEW ENGLAND JOURNAL OF MEDICINE