Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB1R) Receptor with Reduced Lipophilicity

CB 1 R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

(2021) Resat Cinar et al.   Clinical and Translational Medicine

Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

(2021) Charles N. Zawatsky et al.   Frontiers in Endocrinology

The therapeutic potential of second and third generation CB1R antagonists

(2020) Resat Cinar et al.   PHARMACOLOGY & THERAPEUTICS

Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

(2019) Eva Prchalová et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inducible nitric oxide synthase inhibitors: A comprehensive update

(2019) Richa Minhas et al.   MEDICINAL RESEARCH REVIEWS

Synthesis of 13 C6 -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB1 R) and inducible nitric oxide synthase (iNOS)

(2018) Malliga R. Iyer et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis of Diastereomeric Pyrrolidine Sulfamides via Anchimerically Assisted Nucleophilic Substitution Reactions

(2018) Jorge Vargas-Caporali et al.   LETTERS IN ORGANIC CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

(2017) Malliga R. Iyer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Peripherally restricted CB1 receptor blockers

(2013) Robert J. Chorvat   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulating the endocannabinoid system in human health and disease - successes and failures

(2013) Pál Pacher et al.   FEBS Journal

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Probing the Interaction of SR141716A with the CB1 Receptor

(2012) Joong-Youn Shim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis

(2011) Ferdinando A Giannone et al.   LABORATORY INVESTIGATION

Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists

(2010) Jos H.M. Lange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabesity: an overview of a rising epidemic

(2010) Y. M. K. Farag et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists

(2009) Jos H.M. Lange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis

(2009) David R Janero et al.   EXPERT OPINION ON EMERGING DRUGS

Cannabinoid Receptors: Where They are and What They do

(2008) K. Mackie   JOURNAL OF NEUROENDOCRINOLOGY

Identification of Critical Amino Acid Residues for Human iNOS Functional Activity

(2008) Saule Naureckiene et al.   PROTEIN JOURNAL

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

(2008) Denise Richardson et al.   ARTHRITIS RESEARCH & THERAPY