Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The Intrinsically Disordered Region of ExbD is Required for Signal Transduction.

(2020) Dale R. Kopp et al.   JOURNAL OF BACTERIOLOGY

Permeability barriers of Gram-negative pathogens

(2019) Helen I. Zgurskaya et al.   Annals of the New York Academy of Sciences

Siderophore–Antibiotic Conjugate Design: New Drugs for Bad Bugs?

(2019) Negash et al.   MOLECULES

Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin

(2019) Takafumi Sato et al.   CLINICAL INFECTIOUS DISEASES

An overview of recent progress in siderophore-antibiotic conjugates

(2019) Huimin Kong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic

(2018) Rui Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity

(2018) Wilma Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa

(2018) Quentin Perraud et al.   ACS Chemical Biology

Siderophore Conjugates of Daptomycin are Potent Inhibitors of Carbapenem Resistant Strains of Acinetobacter baumannii

(2018) Manuka Ghosh et al.   ACS Infectious Diseases

Subcellular Quantification of Uptake in Gram-Negative Bacteria

(2018) Hans Prochnow et al.   ANALYTICAL CHEMISTRY

Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial

(2018) Simon Portsmouth et al.   LANCET INFECTIOUS DISEASES

Analysis of the clinical antibacterial and antituberculosis pipeline

(2018) Ursula Theuretzbacher et al.   LANCET INFECTIOUS DISEASES

Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo

(2017) Manuka Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bifunctional antimicrobial conjugates and hybrid antimicrobials

(2017) P. Klahn et al.   NATURAL PRODUCT REPORTS

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

(2017) Muriel Masi et al.   Nature Microbiology

Bacteria in an intense competition for iron: Key component of theCampylobacter jejuniiron uptake system scavenges enterobactin hydrolysis product

(2016) Daniel J. Raines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy

(2015) Aryun Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore–antibiotic conjugates

(2015) Tengfei Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy

(2014) Agnieszka Górska et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Predicting Kinetically Unstable CC Bonds from the Ground-State Properties of a Molecule

(2013) Georgios Markopoulos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa

(2013) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutations in Escherichia coli ExbB Transmembrane Domains Identify Scaffolding and Signal Transduction Functions and Exclude Participation in a Proton Pathway

(2013) K. R. Baker et al.   JOURNAL OF BACTERIOLOGY

Bacterial evolution of antibiotic hypersensitivity

(2013) V. Lazar et al.   Molecular Systems Biology

Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciprofloxacin conjugates with potential esterase and phosphatase triggered drug release linkers

(2012) Cheng Ji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biogenesis of membrane bound respiratory complexes in Escherichia coli

(2010) Claire E. Price et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Structural biology of bacterial iron uptake

(2007) Karla D. Krewulak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES