Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection

COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome?

(2021) Michael J. Ombrello et al.   Translational Research

Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes

(2021) Tao Peng et al.   Frontiers in Immunology

Standalone or combinatorial phenylbutyrate therapy shows excellent antiviral activity and mimics CREB3 silencing

(2020) Tejabhiram Yadavalli et al.   Science Advances

The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection

(2019) Rui Zhang et al.   PLoS Pathogens

The ICP0 protein of herpes simplex virus 1 (HSV-1) down-regulates major autophagy adaptor proteins, sequestosome 1 (SQSTM1/p62) and optineurin (OPTN), during the early stages of HSV-1 infection.

(2019) Hope Waisner et al.   JOURNAL OF VIROLOGY

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections

(2019) Raghuram Koganti et al.   Microorganisms

Alcohol consumption promotes colorectal carcinoma metastasis via a CCL5-induced and AMPK-pathway-mediated activation of autophagy

(2018) Haodong Zhao et al.   Scientific Reports

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

(2018) Ghanshyam Swarup et al.   Frontiers in Immunology

The Role of Optineurin in Antiviral Type I Interferon Production

(2018) Ahmed Outlioua et al.   Frontiers in Immunology

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea

(2018) Lulia Koujah et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

(2017) Sjoerd J. L. van Wijk et al.   Nature Microbiology

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

(2016) Karolina Slowicka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TBK1-binding domain of optineurin promotes type I interferon responses

(2016) Netra Pal Meena et al.   FEBS LETTERS

Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes

(2016) Thessicar E. Antoine et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

(2015) T. S. Chew et al.   Disease Models & Mechanisms

Functional analysis of optineurin and some of its disease-associated mutants

(2015) Megha Bansal et al.   IUBMB LIFE

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection

(2015) Abraam M. Yakoub et al.   Scientific Reports

Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

(2015) Pierre Génin et al.   PLoS Pathogens

Herpes Simplex Virus-1 Fine-Tunes Host’s Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models

(2015) Abraam M. Yakoub et al.   PLoS One

Basal Autophagy Is Required for Herpes simplex Virus-2 Infection

(2015) Abraam M. Yakoub et al.   Scientific Reports

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication

(2013) Samantha J. Griffiths et al.   PLoS Pathogens

Tumor-Derived Chemokine CCL5 Enhances TGF- -Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells

(2012) L.-Y. Chang et al.   CANCER RESEARCH

Host Genetic Factors in Susceptibility to Herpes Simplex Type 1 Virus Infection: Contribution of Polymorphic Genes at the Interface of Innate and Adaptive Immunity

(2012) M. Moraru et al.   JOURNAL OF IMMUNOLOGY

CCL5: A Double-Edged Sword in Host Defense Against the Hepatitis C Virus

(2011) Antonios Katsounas et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

A Role for the Chemokine RANTES in Regulating CD8 T Cell Responses during Chronic Viral Infection

(2011) Alison Crawford et al.   PLoS Pathogens

CCL5 participates in early protection against Mycobacterium tuberculosis

(2010) Bridget Vesosky et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

(2010) Jamel Mankouri et al.   PLoS Pathogens

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

(2009) Madhavi Latha Chalasani et al.   OPHTHALMIC RESEARCH

Neurological Complications of Herpes Simplex Virus Type 2 Infection

(2008) Joseph R. Berger et al.   ARCHIVES OF NEUROLOGY