Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections

Drug-encapsulated carbon (DECON): A novel platform for enhanced drug delivery

(2019) Tejabhiram Yadavalli et al.   Science Advances

CRISPR/Cas9 genome editing technology significantly accelerated herpes simplex virus research

(2018) Dong Wang et al.   CANCER GENE THERAPY

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

(2018) Dinesh Jaishankar et al.   Science Translational Medicine

Antiviral Therapies for Herpesviruses: Current Agents and New Directions

(2018) Claudette L. Poole et al.   CLINICAL THERAPEUTICS

Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells

(2018) James Hopkins et al.   JOURNAL OF VIROLOGY

Remodeling of host membranes during herpesvirus assembly and egress

(2018) Ying Lv et al.   Protein & Cell

Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea

(2018) Lulia Koujah et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation

(2018) Ann-Marie Lobo et al.   Ocular Surface

Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8+ T Cells in Exacerbation of Eye Disease

(2018) Ujjaldeep Jaggi et al.   Frontiers in Immunology

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

(2017) Alex M. Agelidis et al.   Cell Reports

A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease

(2017) Dirk Bauer et al.   Frontiers in Microbiology

Targeting Herpes Simplex Virus-1 gD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection

(2017) Tejabhiram Yadavalli et al.   Molecular Therapy-Nucleic Acids

Comparison of Famciclovir, Valaciclovir, and Brivudine Treatments in Adult Immunocompetent Patients With Herpes Zoster

(2016) Mahizer Yaldiz et al.   AMERICAN JOURNAL OF THERAPEUTICS

Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents

(2016) Michael Tsatsos et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Herpesvirus Late Gene Expression: A Viral-Specific Pre-initiation Complex Is Key

(2016) Henri Gruffat et al.   Frontiers in Microbiology

Inhibition of HSV-1 Replication by Gene Editing Strategy

(2016) Pamela C. Roehm et al.   Scientific Reports

Cell entry mechanisms of HSV: what we have learned in recent years

(2015) Alex M Agelidis et al.   Future Virology

Generation and characterization of nucleic acid aptamers targeting the capsid P domain of a human norovirus GII.4 strain

(2015) Matthew D. Moore et al.   JOURNAL OF BIOTECHNOLOGY

Engineering herpes simplex viruses by infection–transfection methods including recombination site targeting by CRISPR/Cas9 nucleases

(2015) Tiffany A. Russell et al.   JOURNAL OF VIROLOGICAL METHODS

Expanding the Biologist’s Toolkit with CRISPR-Cas9

(2015) Samuel H. Sternberg et al.   MOLECULAR CELL

Tegument Assembly and Secondary Envelopment of Alphaherpesviruses

(2015) Danielle Owen et al.   Viruses-Basel

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Human herpes simplex virus: Life cycle and development of inhibitors

(2015) M. K. Kukhanova et al.   BIOCHEMISTRY-MOSCOW

Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012

(2015) Katharine J. Looker et al.   PLoS One

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral drug resistance in herpesviruses other than cytomegalovirus

(2014) Jocelyne Piret et al.   REVIEWS IN MEDICAL VIROLOGY

High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases

(2014) Yanwei Bi et al.   PLoS Pathogens

Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications

(2014) Timothy Chou et al.   Therapeutics and Clinical Risk Management

The Herpesvirus VP1/2 Protein Is an Effector of Dynein-Mediated Capsid Transport and Neuroinvasion

(2013) Sofia V. Zaichick et al.   Cell Host & Microbe

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression

(2013) Natalia Cheshenko et al.   FASEB JOURNAL

Herpes Simplex Virus 1 Glycoprotein M and the Membrane-Associated Protein UL11 Are Required for Virus-Induced Cell Fusion and Efficient Virus Entry

(2013) I.-J. Kim et al.   JOURNAL OF VIROLOGY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody

(2013) A. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycoprotein targeted therapeutics: a new era of anti-herpes simplex virus-1 therapeutics

(2013) Thessicar E. Antoine et al.   REVIEWS IN MEDICAL VIROLOGY

Exploiting Herpes Simplex Virus Entry for Novel Therapeutics

(2013) Satvik Hadigal et al.   Viruses-Basel

Recent advances in vaccine development for herpes simplex virus types I and II

(2013) Jeffrey L. Coleman et al.   Human Vaccines & Immunotherapeutics

Herpesviruses: latency and reactivation – viral strategies and host response

(2013) Bjørn Grinde   Journal of Oral Microbiology

Replication of Herpes Simplex Virus: Egress of Progeny Virus at Specialized Cell Membrane Sites

(2012) R. M. Mingo et al.   JOURNAL OF VIROLOGY

Aptamer That Binds to the gD Protein of Herpes Simplex Virus 1 and Efficiently Inhibits Viral Entry

(2012) S. C. B. Gopinath et al.   JOURNAL OF VIROLOGY

HSV-1 ICP0: paving the way for viral replication

(2011) Miles C Smith et al.   Future Virology

Anti-heparan Sulfate Peptides That Block Herpes Simplex Virus Infectionin Vivo

(2011) Vaibhav Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Virucidal EB Peptide Protects Host Cells from Herpes Simplex Virus Type 1 Infection in the Presence of Serum Albumin and Aggregates Proteins in a Detergent-Like Manner

(2010) H. Bultmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mediators and Mechanisms of Herpes Simplex Virus Entry into Ocular Cells

(2010) Asim V. Farooq et al.   CURRENT EYE RESEARCH

Corneal latency and transmission of herpes simplex virus-1

(2010) Asim V Farooq et al.   Future Virology

Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication

(2010) U. Chuluunbaatar et al.   GENES & DEVELOPMENT

Myosin Va Enhances Secretion of Herpes Simplex Virus 1 Virions and Cell Surface Expression of Viral Glycoproteins

(2010) K. L. Roberts et al.   JOURNAL OF VIROLOGY

Novel approaches in fighting herpes simplex virus infections

(2009) Sarah S Wilson et al.   Expert Review of Anti-Infective Therapy

Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry

(2009) Jihan Akhtar et al.   FEBS Journal

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

(2009) Kristopher Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Herpes Simplex Virus Replication: Roles of Viral Proteins and Nucleoporins in Capsid-Nucleus Attachment

(2008) A. M. Copeland et al.   JOURNAL OF VIROLOGY