Where’s the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome

Diagnostic Testing for Galactose-alpha-1,3-galactose (Alpha-gal), United States, 2010–2018

(2021) Alison M. Binder et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis

(2021) Sumnima Singh et al.   Cell Host & Microbe

Mechanisms of oral immunotherapy

(2021) Suzanne M. Barshow et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tick hypersensitivity and human tick‐borne diseases

(2021) Yu Quan Ng et al.   PARASITE IMMUNOLOGY

α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG4

(2021) Jeffrey M. Wilson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunoglobulin M and Immunoglobulin G Subclass Distribution of Anti-galactose-Alpha-1,3-Galactose and Anti-N-Glycolylneuraminic Acid Antibodies in Healthy Korean Adults

(2021) Eun Jin Lee et al.   TRANSPLANTATION PROCEEDINGS

Current Understanding of Epigenetics in Atopic Dermatitis

(2021) Alina D. Schmidt et al.   EXPERIMENTAL DERMATOLOGY

Molecular Mechanisms of Atopic Dermatitis Pathogenesis

(2021) Jowita Sroka-Tomaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T and B Lymphocyte Transcriptional States Differentiate between Sensitized and Unsensitized Individuals in Alpha-Gal Syndrome

(2021) Onyinye I. Iweala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tick exposures and alpha-gal syndrome: A systematic review of the evidence

(2021) Ian Young et al.   Ticks and Tick-Borne Diseases

Tick salivary gland extract induces alpha‐gal syndrome in alpha‐gal deficient mice

(2021) Shailesh K. Choudhary et al.   Immunity Inflammation and Disease

Transcriptional analysis of B cells from patients with alpha-gal allergy

(2020) Shailesh Choudhary   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Disease Workshop on Understanding IgE-Mediated Mammalian Meat Allergy

(2020) Thomas A.E. Platts-Mills et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Glycolipid-Mediated Basophil Activation in Alpha-Gal Allergy

(2020) Onyinye I. Iweala et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical and serological characterization of the α-Gal syndrome - importance of atopy for symptom severity in a European cohort

(2020) M B Gea Kiewiet et al.   Journal of Allergy and Clinical Immunology-In Practice

Alpha-Gal and Cross-Reactive Carbohydrate Determinants in the N-Glycans of Salivary Glands in the Lone Star Tick, Amblyomma americanum

(2020) Yoonseong Park et al.   Vaccines

The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation

(2020) Alfred Joseph Tector et al.   Frontiers in Immunology

Tick and Host Derived Compounds Detected in the Cement Complex Substance

(2020) Margarita Villar et al.   Biomolecules

Alpha‐gal syndrome: An emerging cause of food and drug allergy

(2020) Krzyszof Rutkowski et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Diagnosis & management of alpha-gal syndrome: lessons from 2,500 patients

(2020) Scott P. Commins   Expert Review of Clinical Immunology

Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer

(2020) Maja Krstić Ristivojević et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A dynamic relationship between two regional causes of IgE-mediated anaphylaxis: α-Gal syndrome and imported fire ant

(2020) Jeffrey M. Wilson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Red Meat Allergies after Lone Star Tick (Amblyomma americanum) Bites

(2020) James H. Diaz   SOUTHERN MEDICAL JOURNAL

B Cell Responses in the Development of Mammalian Meat Allergy

(2020) Jessica L. Chandrasekhar et al.   Frontiers in Immunology

‘Doc, will I ever eat steak again?’

(2020) Chirag Patel et al.   CURRENT OPINION IN PEDIATRICS

Spatial distribution of alpha-gal in Ixodes ricinus – A histological study

(2020) Jörg Fischer et al.   Ticks and Tick-Borne Diseases

Immunobiology of Acquired Resistance to Ticks

(2020) Hajime Karasuyama et al.   Frontiers in Immunology

The human natural anti‐αGal antibody targets common pathogens by broad‐spectrum polyreactivity

(2020) Jens Magnus Bernth Jensen et al.   IMMUNOLOGY

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat

(2019) Christiane Hilger et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Alpha-gal phenotypes- lessons from various patient populations

(2019) Michael Levin. et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The contribution made by skin‐infiltrating basophils to the development of alpha gal syndrome

(2019) R Kageyama et al.   ALLERGY

Only aG al bound to lipids, but not to proteins, is transported across enterocytes as an IgE reactive molecule that can induce effector cell activation

(2019) Patricia Román‐Carrasco et al.   ALLERGY

The Microbiome and Food Allergy

(2019) Onyinye I. Iweala et al.   Annual Review of Immunology

Investigation into the α-Gal Syndrome: Characteristics of 261 Children and Adults Reporting Red Meat Allergy

(2019) Jeffrey M. Wilson et al.   Journal of Allergy and Clinical Immunology-In Practice

Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice

(2019) Xian Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell– and MyD88-Dependent Pathways in Mice

(2019) Jessica L. Chandrasekhar et al.   JOURNAL OF IMMUNOLOGY

Xenoantigen-dependent complement-mediated neutralization of LCMV glycoprotein pseudotyped VSV in human serum

(2019) Lisa Pipperger et al.   JOURNAL OF VIROLOGY

Red meat desensitization in a child with delayed anaphylaxis due to alpha‐Gal allergy

(2019) Esra Yucel et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy

(2019) Gary Crispell et al.   Frontiers in Immunology

Environmental and Molecular Drivers of the α-Gal Syndrome

(2019) Alejandro Cabezas-Cruz et al.   Frontiers in Immunology

The clinical presentation of alpha-gal allergy among pediatric patients with food allergy in southwest Missouri

(2019) Breahn Donaldson et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Allergy in frequent travelers: the alpha-gal story and the first UK case series.

(2019) Verah Harper et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

IgE to galactose-α-1,3-galactose wanes over time in patients who avoid tick bites

(2019) Margaret Shin Kim et al.   Journal of Allergy and Clinical Immunology-In Practice

Tick Bites Induce Anti-α-Gal Antibodies in Dogs

(2019) Adnan Hodžić et al.   Vaccines

IgE to the Mammalian Oligosaccharide Galactose-α-1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable Characteristics—Brief ReportHighlights

(2018) Jeffrey M. Wilson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

How do basophils contribute to Th2 cell differentiation and allergic responses?

(2018) Hajime Karasuyama et al.   INTERNATIONAL IMMUNOLOGY

Detection of antigen-specific IgE-expressing B cells in food allergy is feasible and inversely associated with dietary antigen exposure

(2018) Shailesh Choudhary et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Repeated Amblyomma testudinarium tick bites are associated with increased galactose-α-1,3-galactose carbohydrate IgE antibody levels: A retrospective cohort study in a single institution

(2018) Hideo Hashizume et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Tick-induced allergies: mammalian meat allergy and tick anaphylaxis

(2018) Sheryl A van Nunen   MEDICAL JOURNAL OF AUSTRALIA

Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges

(2018) Shelley Dua et al.   Journal of Allergy and Clinical Immunology-In Practice

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

(2018) Caroline L. Sokol et al.   IMMUNITY

The basophil activation test differentiates between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization

(2018) Jana Mehlich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps

(2018) Guan-Ting Zhai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Predictive values of alpha-gal IgE levels and alpha-gal IgE: Total IgE ratio and oral food challenge-proven meat allergy in a population with a high prevalence of reported red meat allergy

(2018) Tshegofatso Mabelane et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

α-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells

(2018) M. Krstić Ristivojević et al.   Scientific Reports

Could chiggers be contributing to the prevalence of galactose-alpha-1,3-galactose sensitization and mammalian meat allergy?

(2018) Lindsey P. Stoltz et al.   Journal of Allergy and Clinical Immunology-In Practice

An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy

(2018) Kelly M. Cox et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Genetically Modified Pigs as Organ Donors for Xenotransplantation

(2017) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

The quantity and quality of α-gal-specific antibodies differ in individuals with and without delayed red meat allergy

(2016) D. Kollmann et al.   ALLERGY

Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment

(2016) Onyinye I. Iweala et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Amblyomma sculptum tick saliva: α-Gal identification, antibody response and possible association with red meat allergy in Brazil

(2016) Ricardo Nascimento Araujo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge

(2016) John W. Steinke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE in the diagnosis and treatment of allergic disease

(2016) Thomas A.E. Platts-Mills et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Haemaphysalis longicornistick bites are a possible cause of red meat allergy in Japan

(2015) Y. Chinuki et al.   ALLERGY

Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex

(2015) Will Van Treuren et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The alpha-gal story: Lessons learned from connecting the dots

(2015) John W. Steinke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Revisiting the role of B cells in skin immune surveillance

(2015) Isioma U. Egbuniwe et al.   TRENDS IN IMMUNOLOGY

Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

(2014) Bahtiyar Yilmaz et al.   CELL

IgE antibodies to alpha-gal in the general adult population: relationship with tick bites, atopy, and cat ownership

(2014) A. Gonzalez-Quintela et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A Ten-Year Retrospective Analysis of the Distribution, Use and Phenotypic Characteristics of the LAD2 Human Mast Cell Line

(2014) Arnold S. Kirshenbaum et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose

(2014) Scott P. Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tick Saliva Inhibits Dendritic Cell Migration, Maturation, and Function while Promoting Development of Th2 Responses

(2014) Anna Skallová et al.   JOURNAL OF IMMUNOLOGY

Microbial Population Analysis of the Salivary Glands of Ticks; A Possible Strategy for the Surveillance of Bacterial Pathogens

(2014) Yongjin Qiu et al.   PLoS One

Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha-gal and allergy to red meat

(2013) S. Michel et al.   ALLERGY

Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tickIxodes ricinus; possible relationship with red meat allergy

(2013) C. Hamsten et al.   ALLERGY

Diversity of Rickettsiales in the Microbiome of the Lone Star Tick, Amblyomma americanum

(2013) Loganathan Ponnusamy et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Invariant natural killer T cells in children with eosinophilic esophagitis

(2013) S. Jyonouchi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tick bites and red meat allergy

(2013) Scott P. Commins et al.   Current Opinion in Allergy and Clinical Immunology

Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells

(2013) Jolien Suurmond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits

(2013) Uri Galili   IMMUNOLOGY

Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups

(2013) Carl Hamsten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Galactose- -1,3-galactose and Delayed Anaphylaxis, Angioedema, and Urticaria in Children

(2013) J. L. Kennedy et al.   PEDIATRICS

How ticks get under your skin: insertion mechanics of the feeding apparatus of Ixodes ricinus ticks

(2013) D. Richter et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells

(2012) Joseph P. Sanderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin

(2011) Soma Jyonouchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Delayed mammalian meat–induced anaphylaxis due to galactose-α-1,3-galactose in 5 European patients

(2011) Ramón Nuñez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose

(2011) Scott P. Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deconstructing Tick Saliva

(2011) Carlo José F. Oliveira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

CD1d-Mediated Interaction Between Activated T Cells and B Cells Is Essential to B-Cell Proliferation and Anti-α-Gal Antibody Production

(2009) S. Liu et al.   TRANSPLANTATION PROCEEDINGS

Where Do MAIT Cells Fit in the Family of Unconventional T Cells?

(2009) Laurent Gapin   PLOS BIOLOGY

Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-α-1,3-galactose

(2008) Scott P. Commins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE