Article
Neurosciences
Fanen Yuan, Si Zhang, Qian Sun, Liguo Ye, Yang Xu, Zhou Xu, Gang Deng, Shenqi Zhang, Baohui Liu, Qianxue Chen
Summary: The study demonstrated that hsa_circ_0072309 promotes autophagy through the p53 signaling pathway and enhances sensitivity to temozolomide in GBM. It may serve as a potential and promising target in designing treatment strategies for GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Virology
Shan-Ying Wu, Yu-Lun Chen, Ying-Ray Lee, Chiou-Feng Lin, Sheng-Hui Lan, Kai-Ying Lan, Man-Ling Chu, Pei-Wen Lin, Zong-Lin Yang, Yen-Hsu Chen, Wen-Hung Wang, Hsiao-Sheng Liu
Summary: This study reveals that DENV2 induces autophagy in lung and liver cancer cells, resulting in the formation of double-membrane autophagosomes containing viral proteins and full-length RNAs that are infectious. Additionally, DENV2 promotes HMGB1 exocytosis through secretory autophagy.
Article
Immunology
Jinlin Wen, Panpan Yin, Ying Su, Feng Gao, Yanlin Wu, Wenbin Zhang, Peng Chi, Jiahui Chen, Xinyan Zhang
Summary: This study found that high mobility group box 1 (HMGB1) plays an important role in modulating the crosstalk between tumor-associated macrophages (TAMs) and oral squamous cell carcinoma (OSCC) cells. HMGB1 is involved in regulating TAM polarization, cell recruitment, and tumor progression in OSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fei Tong, Ji-xing Zhao, Zi-yuan Fang, Xiao-teng Cui, Dong-yuan Su, Xing Liu, Jun-hu Zhou, Guang-xiu Wang, Zhi-jun Qiu, Shi-zhong Liu, Jun-qi Fu, Chun-sheng Kang, Jia-chong Wang, Qi-xue Wang
Summary: Based on CRISPR-Cas9 library screening, we found that MUC1-C is essential for EGFRvIII glioma cell survival and TMZ resistance. By inhibiting the NF-kappa B pathway, EPIC-1027 disrupts the EGFRvIII-MUC1-C positive feedback loop, inhibits glioma progression, and increases sensitivity to TMZ.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nidhi Chaudhary, Shikha Srivastava, Sunny Gupta, Manoj B. Menon, Ashok Kumar Patel
Summary: This study reveals the role of HMGB1 in regulating the cellular autophagy process during DENV-2 infection. Inhibition of autophagy or silencing of HMGB1 reduces DENV-2 replication, while induction of HMGB1 enhances autophagy and promotes viral replication. The HMGB1 inhibitor glycyrrhizic acid also suppresses autophagy and DENV-2 replication. Overall, HMGB1 induces BECN1 dependent autophagy to facilitate DENV-2 replication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Neurosciences
Yona Kim, Frederick S. Varn, Sung-Hye Park, Byung Woo Yoon, Hye Ran Park, Charles Lee, Roel G. W. Verhaak, Sun Ha Paek
Summary: GBM remains a challenging disease to treat due to its high intra- and inter-tumoral heterogeneity, with the mesenchymal subtype being associated with the most aggressive and treatment-resistant features. Research efforts have focused on identifying and understanding the master mesenchymal regulators and their downstream signaling pathways in order to develop more personalized therapeutic strategies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Oncology
Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Yan Wang, Rutong Yu, Xiuping Zhou
Summary: YAP over-expression enhances glioma cell autophagy and progression by promoting the translocation of HMGB1 from nucleus to cytoplasm, suggesting a potential therapeutic target in GBM. The combination of chemo-radiotherapy with pharmacological autophagy inhibition for treating GBM patients with YAP high expression may be a promising clinical opportunity.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Sai Qiao, Ying Cheng, Miao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Daozhou Liu, Siyuan Zhou
Summary: This paper aims to establish a new GBM-targeted drug delivery system using zoledronate to treat TMZ-resistant GBM. The system can inhibit the growth of TMZ-resistant GBM by inducing apoptosis, regulating the proportion of macrophages, and improving the immunosuppressive and hypoxic microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Yan Zou, Zi'xiang Liu, Yi'nan Zhou, Jing Wang, Qin'yi Xu, Xu'dong Zhao, Zeng'li Miao
Summary: Research has found that TRPC5 and P-gp are upregulated in TMZ-resistant glioblastoma cells, and downregulation of TRPC5 can inhibit P-gp expression and significantly reverse TMZ resistance; TRPC5-siRNA limited the tumor xenograft growth of TMZ-resistant cells in an athymic nude mouse model; in specimens from patients with recurrent glioblastoma, TRPC5 and P-gp are highly expressed.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Chengbo Wang, Maodong Leng, Cong Ding, Xiangzhan Zhu, Yaodong Zhang, Chenchen Sun, Pu Lou
Summary: This study reveals the significant roles of autophagy-dependent ferroptosis and HMGB1 in MTX-induced hepatotoxicity, and emphasizes the potential of inhibiting ferritinophagy and HMGB1 as a therapeutic approach for preventing and treating liver injury caused by MTX.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Lujia Feng, Liang Liang, Shaochong Zhang, Jinglu Yang, Yanan Yue, Xuedong Zhang
Summary: This study investigated the relationship between HMGB1, the macroautophagy/autophagy-lysosome pathway, and DR, finding that high glucose inhibited autophagy and diminished its degradative capacity due to lysosome membrane permeabilization. HMGB1 was involved in lysosome membrane permeabilization via the CTSB-dependent pathway in the early stages of DR.
Article
Immunology
Omid Teymournejad, Aditya Kumar Sharma, Mohammed Abdelwahed, Muhamuda Kader, Ibrahim Ahmed, Hoda Elkafas, Nahed Ismail
Summary: This study reveals the role of hepatocytes in the MyD88 signaling pathway during Ehrlichia infection. MyD88 signaling leads to hepatocyte damage and inflammatory cell death, while controlling bacterial replication. Additionally, MyD88 promotes hepatocyte autophagy and regulates autophagy by inhibiting mTORC1 activation. Understanding hepatocyte-specific signaling is critical for the development of new therapeutics against liver-targeting pathogens such as Ehrlichia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Seung-Woo Kim, Sang-A Oh, Song- Seol, Dashdulam Davaanyam, Ja-Kyeong Lee
Summary: The study found that HMGB1 plays a critical role in mediating NOD2-induced autophagy in microglia. Cytoplasmic accumulation of HMGB1 activates a cell-autonomous pro-autophagic pathway, while extracellular secretion of HMGB1 activates a cell-autonomous pro-inflammatory pathway.
Article
Cell Biology
Yang Wu, Sophie Franzmeier, Friederike Liesche-Starnecker, Juergen Schlegel
Summary: The study reveals the important role of ALDH1A3 in glioblastoma cells, which is associated with resistance and tumor recurrence. RSL3, a ferroptosis inducer, shows potential for the treatment of glioblastoma relapse.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Energy & Fuels
Zewen Jin, Xiaoling Zhang, Xiaomin Chen, Zhenjie Du, Lifeng Ping, Zhaoqiang Han, Pengchuang Tao
Summary: Applying biochar to agricultural soils can sequester carbon, improve soil health, and enhance agricultural sustainability. However, our knowledge of the long-term effects of biochar on soil organic carbon mineralization and enzyme activities under field conditions is limited.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Engineering, Civil
Qian Ye, Kaan Ozbay, Fan Zuo, Xiaohong Chen
Summary: This study analyzes the effect of social media on human mobility before and after the COVID-19 outbreak, specifically looking at personal vehicle and public transit use in New York City. The results show a negative correlation between Twitter volume and mobility trends, indicating that social media has an impact on travel decisions. Additionally, the study highlights the different impacts of social media and government policies on vehicular traffic and public transit ridership during the pandemic.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Agronomy
Shimin Hu, Can Chen, Xiaomin Chen, Feng Jing, Xin Wen
Summary: This study demonstrates that the application of wheat straw biochar can effectively improve the adsorption and accumulation process of Cd2+ in Cd-contaminated soil while inhibiting the migration of Cd into rice, hence reducing the Cd concentration in rice.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Review
Food Science & Technology
Xiaoyan Chen, Gene Chi Wai Man, Sze Wan Hung, Tao Zhang, Linda Wen Ying Fung, Chun Wai Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li, Chi Chiu Wang
Summary: Endometriosis, a chronic disorder affecting many women, is currently difficult to treat effectively. However, recent studies have shown that green tea, with its bioactive component EGCG, may have potential therapeutic effects on endometriosis by inhibiting various molecular and cellular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Computer Science, Artificial Intelligence
Xiang Jia, Liang Wang, Ying-Ming Wang, Hui-Hui Song
Summary: This paper proposes a two-sided matching decision-making (TSMDM) approach with probabilistic linguistic evaluations. By normalizing and aggregating the evaluations, satisfaction degrees are calculated and a multi-objective TSMDM model is built aiming to maximize the comprehensive satisfaction degree. Results from an illustrative example show that the proposed approach can avoid information loss and effectively integrate probabilistic linguistic term sets with correlative criteria.
INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY & DECISION MAKING
(2023)
Article
Biochemistry & Molecular Biology
Xiaodong Chen, Ling Fang, Fuhua Peng, Yuge Wang, Zhengjia Dai, Jinhui Wang, Yaqing Shu, Wei Qiu
Summary: Anti-NMDAR encephalitis affects the limbic system and causes functional connectivity alterations in the posterior default mode network. Serum neurofilament light chains (sNfL) are linked with disease severity and functional changes. This study provides insights into the relationship between sNfL levels and functional organization in anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Dan Zhao, Xiaoyu Huang, Yanan Tian, Jianhua Zou, Fu Wang, Xiaoyuan Chen
Summary: Ferroptosis is a new type of programmed cell death that plays a crucial role in tumor inhibition. This study introduces a facile fluorescence imaging-incorporated transcriptome strategy to visualize and explore the mechanism of GSH depletion-enhanced ferroptosis. The results demonstrate that TfRA-AuNCs, a multifunctional nanoplatform, can enhance the ferroptosis effect in 4T1 cells and regulate the expression change of ferroptosis-related genes. In vivo results confirm the tumor inhibition effect and long-term biocompatibility after TfRA-AuNC treatment. This study provides new insights into the mechanistic study of nanoagent-induced ferroptosis in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Zhao, Yuanwei Pan, Guocan Yu, Xing-Zhong Zhao, Xiaoyuan Chen, Lang Rao
Summary: The high stability and binding specificity of antibodies make them widely applicable in various diseases. However, there are limitations to traditional antibody-based therapeutics. Recent advances in cell membrane nanotechnology have led to the development of vesicular-antibody-based therapeutics, which offer new possibilities for disease treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yingming Wang, Hui Huang, Jie Wu, Hongyuan Yang, Zhenhui Kang, Yang Liu, Zhaowu Wang, Prashanth W. W. Menezes, Ziliang Chen
Summary: Se-vacancy with charge polarization is created in the NiSe2 structure, which enhances the stability, decreases the electron transfer kinetics, and optimizes the free adsorption energy of reaction intermediate. The prepared NiSe2-V-Se exhibits high selectivity in alkaline media and excellent stability over a wide potential range.
Review
Chemistry, Multidisciplinary
Lujie Liu, Yuanwei Pan, Chenchen Zhao, Peng Huang, Xiaoyuan Chen, Lang Rao
Summary: Immune checkpoint blockade (ICB) therapy has made significant advancements in cancer treatment, but limited response rates and systemic toxicity hinder its clinical outcomes. Biomaterials have been developed to enhance ICB therapy by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor immune response, and improving targeted delivery of checkpoint inhibitors. This review discusses current design strategies for biomaterials, their applications in immune modulation and targeted delivery of checkpoint inhibitors for effective ICB therapy, as well as the challenges and future prospects in this field. It is anticipated that this review will contribute to the development of emerging biomaterials for ICB therapy and the advancement of its clinical application.
Article
Computer Science, Artificial Intelligence
Ying-Ming Wang, Shi-Fan He, Diego Garcia Zamora, Xiao-Hong Pan, Luis Martinez
Summary: This paper proposes a Large-Scale Group Decision-Making method to select the best location for charging stations. The method uses HFLTS and ELICIT model to improve the elicitation process and introduces a TWD-CRP method to improve the group's agreement.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Computer Science, Artificial Intelligence
Zi-Xin Zhang, Liang Wang, Ying-Ming Wang, Luis Martinez
Summary: This study proposes a novel alpha level sets based fuzzy DEMATEL method to handle fuzzy information and considers experts' hesitation under uncertain and fuzzy environment. The proposed method improves the existing fuzzy DEMATEL studies and enriches the theoretical studies of fuzzy DEMATEL.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Tianyu Yang, Ziliang Chen, Yingming Wang, Hui Huang, Kui Yin, Fan Liao, Yang Liu, Zhenhui Kang
Summary: An oriented coupling strategy is developed for the acidic hydrogen evolution reaction by in situ inserting hollow porous Co/NC nanocage by Si nanowires, which delivers remarkable activity and stability. The presence of Si nanowire toward Co/NC polyhedra not only facilitates the charge transfer during catalysis, but also optimizes the hydrogen adsorption and desorption.
Article
Oncology
Li-Qin Xu, Shu-Wen Zhang, Rui Zhang, Jing-Jing Chen, Zai-Xin Yuan, Jian Feng, Jian-An Huang
Summary: This study investigates the role of transcriptional adaptor 3 (TADA3) in non-small cell lung cancer (NSCLC). The results show that TADA3 is overexpressed in NSCLC specimens and cell lines. Silencing TADA3 suppresses proliferative, migratory, and invasive abilities of NSCLC cells in vitro and inhibits tumor growth in a mouse xenograft model. TADA3 silencing also alters the expression pattern of epithelial-mesenchymal transition (EMT) markers. These findings highlight the significance of TADA3 in regulating NSCLC growth and metastasis.
Article
Engineering, Industrial
Xiaohong Chen, Tianhu Deng, Zuo-Jun Max Shen, Yi Yu
Summary: This article introduces the mission of the Institute of Industrial and Systems Engineers (IISE) and the problems it faces. It identifies three major bottlenecks that limit the industrial implementation of research outcomes and proposes potential solutions, highlighting the importance of data-driven decision methods.