Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

(2021) Xiao-Ning Zhang et al.   CELL RESEARCH

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Targeting Chromosomal Architectural HMGB Proteins Could Be the Next Frontier in Cancer Therapy

(2020) Anirban Mukherjee et al.   CANCER RESEARCH

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignancies

(2020) Shunling Yuan et al.   Journal of Hematology & Oncology

Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion

(2020) Young Hun Kim et al.   Autophagy

Immunocytokines are a promising immunotherapeutic approach against glioblastoma

(2020) Tobias Weiss et al.   Science Translational Medicine

Glioblastoma vs temozolomide: can the red queen race be won?

(2019) Anjali Arora et al.   CANCER BIOLOGY & THERAPY

Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury

(2019) Lin-Li Lv et al.   CELL DEATH AND DIFFERENTIATION

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation

(2018) Xiaoyan Zhang et al.   Autophagy

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

(2018) Xiaoyan Zhang et al.   DEVELOPMENTAL CELL

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

(2018) Eric Ubil et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

(2018) Sabine Hombach-Klonisch et al.   PHARMACOLOGY & THERAPEUTICS

HMGB1 represses the anti-cancer activity of sunitinib by governing TP53 autophagic degradation via its nucleus-to-cytoplasm transport

(2018) Peihua Luo et al.   Autophagy

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Danger signals: Chemotherapy enhancers?

(2017) Thaiz Rivera Vargas et al.   IMMUNOLOGICAL REVIEWS

High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells

(2017) Xi-Long Zhao et al.   JOURNAL OF PATHOLOGY

Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

(2017) Shai Bel et al.   SCIENCE

C1q and HMGB1 reciprocally regulate human macrophage polarization

(2016) M. Son et al.   BLOOD

Pivotal role of high-mobility group box 1 (HMGB1) signaling pathways in glioma development and progression

(2016) Efthalia Angelopoulou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function

(2016) Weiyue Zheng et al.   NATURE CELL BIOLOGY

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells

(2016) Sandra Pinet et al.   Oncotarget

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

(2015) Yao Liu et al.   JOURNAL OF HEPATOLOGY

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization

(2015) Geming Lu et al.   Nature Communications

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Primate-Specific miR-663 Functions as a Tumor Suppressor by Targeting PIK3CD and Predicts the Prognosis of Human Glioblastoma

(2014) Y. Shi et al.   CLINICAL CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2

(2014) Z Wang et al.   ONCOGENE

HMGB1 in Cancer: Good, Bad, or Both?

(2013) R. Kang et al.   CLINICAL CANCER RESEARCH

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Differentiation and gene expression profile of tumor-associated macrophages

(2012) Astrid Schmieder et al.   SEMINARS IN CANCER BIOLOGY

Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

(2011) Justin D. Lathia et al.   Cell Stem Cell

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression

(2009) James F Curtin et al.   PLOS MEDICINE