Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

(2019) Yan Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

(2019) Darcy Welch et al.   PLoS One

Rhabdomyosarcoma, Ewing Sarcoma, and Other Round Cell Sarcomas

(2018) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

The landscape of genomic alterations across childhood cancers

(2018) Susanne N. Gröbner et al.   NATURE

The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex

(2017) Yupeng He et al.   Nature Chemical Biology

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Suberoylanilide hydroxamic acid synergistically enhances the antitumor activity of etoposide in Ewing sarcoma cell lines

(2015) Rebekka Unland et al.   ANTI-CANCER DRUGS

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

(2015) K. Agelopoulos et al.   CLINICAL CANCER RESEARCH

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

(2015) I Rettig et al.   Cell Death & Disease

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

(2015) Eleni M. Tomazou et al.   Cell Reports

jvenn: an interactive Venn diagram viewer

(2014) Philippe Bardou et al.   BMC BIOINFORMATICS

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

Doxorubicin Enhances Nucleosome Turnover around Promoters

(2013) Fan Yang et al.   CURRENT BIOLOGY

Histone deacetylases govern heterochromatin in every phase

(2013) Yota Murakami   EMBO JOURNAL

Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

(2013) Denise A. Yardley et al.   JOURNAL OF CLINICAL ONCOLOGY

A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: A children's oncology group phase 1 consortium study

(2013) Trent R. Hummel et al.   PEDIATRIC BLOOD & CANCER

Multiple roles of class I HDACs in proliferation, differentiation, and development

(2012) Nina Reichert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A Children's Oncology Group phase I consortium study (ADVL0916)

(2012) Jodi A. Muscal et al.   PEDIATRIC BLOOD & CANCER

Molecular Pathogenesis of Ewing Sarcoma: New Therapeutic and Transcriptional Targets

(2011) Stephen L. Lessnick et al.   Annual Review of Pathology-Mechanisms of Disease

Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2

(2011) Stefan Burdach et al.   CELL CYCLE

Entinostat for treatment of solid tumors and hematologic malignancies

(2011) Jeffrey Knipstein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors

(2011) T. G. P. Grunewald et al.   MOLECULAR CANCER RESEARCH

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

The molecular pathogenesis of Ewing sarcoma

(2010) Carlos Mackintosh et al.   CANCER BIOLOGY & THERAPY

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

(2010) Roel H Wilting et al.   EMBO JOURNAL

Pediatric Phase I Trial and Pharmacokinetic Study of Vorinostat: A Children's Oncology Group Phase I Consortium Report

(2010) Maryam Fouladi et al.   JOURNAL OF CLINICAL ONCOLOGY

Ewing's sarcoma

(2010) Naomi J Balamuth et al.   LANCET ONCOLOGY

Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program

(2009) Nino Keshelava et al.   PEDIATRIC BLOOD & CANCER

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis

(2008) Wilko Weichert et al.   LANCET ONCOLOGY

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY