Article
Environmental Sciences
Lorenzo Fortuna, Aridane G. Gonzalez, Mauro Tretiach, Oleg S. Pokrovsky
Summary: Despite the widespread use of lichens as biomonitors of airborne trace elements, the surface chemistry and metal adsorption parameters of these organisms are still poorly understood. This study quantified the acid-base surface properties and metal adsorption of Pseudevernia furfuracea, and found that lichen samples had higher metal-binding site concentrations compared to mosses. Although the adsorption parameters of lichens were lower than mosses, they were still able to adsorb the same amount of Cu2+ and more Zn2+.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Garima Singh, Daniele Armaleo, Francesco Dal Grande, Imke Schmitt
Summary: The study identified the most likely PKS and FAS responsible for specific chemotypes of lichen Pseudevernia furfuracea using comparative genomics and metatranscriptomics. Results suggest that gene regulation and other epigenetic factors can determine the production of specific compounds by the mycobiont, indicating chemotype diversity in lichens may arise through regulatory factors rather than solely genetic diversity.
Article
Biotechnology & Applied Microbiology
Sinem Ozenoglu-Aydinoglu, Hatice Yildizhan, Demet Cansaran-Duman
Summary: In this study, the protein level changes in Pseudevernia furfuracea in response to Cr+6 heavy metal stress were investigated using a proteomic assay, revealing 9 proteins associated with stress signaling, transcription regulation, and cellular detoxification metabolisms. The up-regulation of proteins such as HSP60 and down-regulation of proteins like MNS1 were observed after exposure to Cr+6, suggesting their involvement in biological processes under heavy metal stress. The study provides valuable insights into the potential use of P. furfuracea as a biosorption agent for industrial waste removal in biotechnological applications.
Article
Biodiversity Conservation
L. Lucadamo, L. Gallo, G. Vespasiano, A. Corapi
Summary: Using a high-density lichen transplant network and quantitative wind relationships, the study evaluated the influence of an airport and surrounding road network on the spatial variation of PAHs and trace elements. The results showed that different areas such as the parking/idling/taxiing area and specific parts of the road network contributed to the spatial variation of elements and PAHs. Moreover, wind speeds played a significant role in the spatial distribution of anthropogenic emissions and contamination patterns.
ECOLOGICAL INDICATORS
(2021)
Article
Pharmacology & Pharmacy
Rishu Kalra, Xavier A. Conlan, Carlos Areche, Rahul Dilawari, Mayurika Goel
Summary: The study focused on finding the best extraction method for Pseudevernia furfuracea lichen, determining the concentrations of atraric acid and olivetoric acid, and investigating the antioxidant potential of the extract. The results showed that the 70% methanol extract had the highest concentration of both compounds and the extraction process could be improved with pre-processing techniques. Additionally, the bioactive extract exhibited protective effects against hydroxyl radicals and showed no significant cytotoxicity against HEK 293 T cell line.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martin Kello, Tomas Kuruc, Klaudia Petrova, Michal Goga, Zuzana Michalova, Matus Coma, Dajana Rucova, Jan Mojzis
Summary: The study investigated the anti-leukemic potential of lichen extract and physodic acid in ALL treatment, demonstrating their ability to induce cell death while causing minimal toxicity in normal cells.
Article
Multidisciplinary Sciences
Laura Wiggins, Alice Lord, Killian L. Murphy, Stuart E. Lacy, Peter J. O'Toole, William J. Brackenbury, Julie Wilson
Summary: CellPhe is a pattern recognition toolkit that enables unbiased characterization of cellular phenotypes within time-lapse videos. It imports tracking information from multiple algorithms and provides automated recognition and removal of erroneous cell boundaries. It also offers a variety of feature selection and classification algorithms.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Murat Topal, E. Isil Arslan Topal, Erdal Obek, Ali Aslan
Summary: The study revealed potential health risks associated with the consumption of Pseudevernia furfuracea, particularly for children and women, due to toxic elements such as chromium and manganese. The exposure to these elements may pose a carcinogenic risk for women and children.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemical Research Methods
Hyun Gyu Lee, Kyoung J. Lee
Summary: Proper cell-cell adhesiveness can enhance the super-diffusive nature of individual cells and promote cell movement within a dense population. Interestingly, research shows that cell dispersal within a densely packed population differs from free crawling, and this phenomenon can be explained by a simple cellular Potts model.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrea R. Marcadis, Elizabeth Kao, Qi Wang, Chun-Hao Chen, Laxmi Gusain, Ann Powers, Richard L. Bakst, Sylvie Deborde, Richard J. Wong
Summary: The invasion of nerves by cancer cells, or perineural invasion (PNI), is influenced by the nerve microenvironment and is associated with negative clinical outcomes. However, the specific characteristics of cancer cells that enable PNI have not been well defined. Through serial passaging of pancreatic cancer cells in a murine sciatic nerve model of PNI, we generated cell lines enriched for a rapid neuroinvasive phenotype. These leading neuroinvasive cells exhibited upregulation of proteins involving the plasma membrane, cell leading edge, and cell movement. They also underwent phenotypic changes from a mesenchymal to an amoeboid phenotype, and acquired increased migration ability and affinity for dorsal root ganglia. Inhibition of ROCK reversed these changes and reduced PNI in a murine sciatic nerve model. This study highlights the plasticity of cancer migration mode in facilitating rapid nerve invasion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Shun Yao, Feifei Shi, Ning Mu, Xiaopeng Li, Guilin Ma, Yingying Wang, Xiaoyang Sun, Xiangguo Liu, Ling Su
Summary: AAMP, considered a pro-tumor protein, is upregulated in non-small cell lung carcinoma and promotes migration and invasion in NSCLC cells. It interacts with CDC42 to activate it, leading to the formation of cellular protrusions. AAMP enhances CDC42 activation by impairing the combination of ARHGAP1 and CDC42.
Article
Multidisciplinary Sciences
Maria Akhmanova, Shamsi Emtenani, Daniel Krueger, Attila Gyoergy, Mariana Guarda, Mikhail Vlasov, Fedor Vlasov, Andrei Akopian, Aparna Ratheesh, Stefano De Renzis, Daria E. Siekhaus
Summary: This study reveals that cellular infiltration in densely packed tissues requires cell division and tissue dynamics regulation.
Article
Engineering, Biomedical
Qiyao Peng, Fred J. Vermolen, Daphne Weihs
Summary: Cancer cell migration plays a crucial role in cancer metastasis, the leading cause of patient mortality. Researchers developed a model to investigate the effect of mechanical interactions on the transmigration of cancer cells through narrow channels and cavities. Results showed that distant follower cells have a significantly higher transmigration speed compared to leader cells, while closely adjacent cells exhibit collective migration with the leader cell moving faster due to the push from the follower cell. These findings highlight the importance of mechanical interactions in accelerating cancer metastasis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Jose M. Prieto, Mohd Mukrish Mohd Hanafi
Summary: Prostate cancer is a global health burden and scientific challenge. Malaysia's rich biodiversity, including the oldest rainforest in the world and numerous medicinal plants, offers potential for sustainable sources of prostate cancer chemotherapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Applied
Rishu Kalra, Xavier A. Conlan, Manish Gupta, Carlos Areche, Mamta Bhat, Mayurika Goel
Summary: UHPLC/ESI/MS/MS profiling and bioactivity-guided isolation of Pseudevernia furfuracea extract led to the identification of two polyphenolic compounds, Methyl haematommate and Atraric acid. The bioactivity evaluation against cancerous cell lines revealed that Atraric acid showed significant activity against ovarian cancer cells and moderate activity against breast cancer cells. Molecular docking studies further supported the potential of Atraric acid as an EGFR inhibitor. These findings highlight the potential of P. furfuracea and Atraric acid as promising candidates for ovarian cancer management.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Milena M. Jovanovic, Dragana S. Seklic, Jelena D. Rakobradovic, Nevena S. Planojevic, Nenad L. Vukovic, Milena D. Vukic, Snezana D. Markovic
Summary: The study found that royal jelly and its component 10H2DA have inhibitory effects on the invasion and metastasis of colorectal cancer cells, and can stabilize intercellular connections. These findings provide a new explanation for the anticancer potential of royal jelly and 10H2DA.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Sandra Nikolic, Marina Gazdic-Jankovic, Gvozden Rosic, Marina Miletic-Kovacevic, Nemanja Jovicic, Natasa Nestorovic, Petra Stojkovic, Nenad Filipovic, Olivera Milosevic-Djordjevic, Dragica Selakovic, Marko Zivanovic, Dragana Seklic, Nevena Milivojevic, Aleksandra Markovic, Richard Seist, Sasa Vasilijic, Konstantina M. Stankovic, Miodrag Stojkovic, Biljana Ljujic
Summary: Research demonstrates that microplastics and nanoparticles can accumulate in animals and induce changes in cellular and organ functions, potentially impacting health.
ENVIRONMENTAL POLLUTION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Milos Papic, Suzana Zivanovic, Tamara Vucicevic, Mirjana Papic, Dejan Zdravkovic, Nevena Milivojevic, Katarina Virijevic, Marko Zivanovic, Aleksandar Mircic, Biljana Ljujic, Miodrag L. Lukic, Milica Popovic
Summary: This study aimed to evaluate the effect of direct pulp capping on the expression of erythropoietin (Epo) and Epo-receptor (Epor) genes in relation to the expression of inflammatory and osteogenic genes in rat pulp. The study found that pulp capping can promote anti-inflammatory and pulp regeneration. The capped pulps showed higher expressions of Epo, while the untreated pulps had the highest expression of Epor and inflammatory cytokines. The materials used for capping played a positive role in regulating the expression of inflammatory and pulp osteogenic factors.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kristina Z. Mihajlovic, Vera M. Divac, Marina D. Kostic, Marko N. Zivanovic, Jelena Grujic, Katarina Virijevic
Summary: Terpenic alcohols linalool, nerolidol and β-terpineol were cyclized using PhSe, resulting in the formation of cyclic ethers. These cyclic ether products, which contain an organoselenium moiety, showed strong prooxidative properties in both colon cancer cells and healthy cells in vitro.
MACEDONIAN JOURNAL OF CHEMISTRY AND CHEMICAL ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Dragana S. Seklic, Tijana Dukic, Dejan Milenkovic, Milena M. Jovanovic, Marko N. Zivanovic, Zoran Markovic, Nenad Filipovic
Summary: This study categorized the progression of epithelial-mesenchymal transition (EMT) in colorectal cancer using numerical modeling and experimental validation. The effectiveness of treatment in EMT suppression was assessed, and the sensitivity and anti-migratory/invasive effects varied between different cell types and treatments.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Virology
Sanja Matic, Dragan Milovanovic, Zeljko Mijailovic, Predrag Djurdjevic, Predrag Sazdanovic, Srdjan Stefanovic, Danijela Todorovic, Suzana Popovic, Katarina Vitosevic, Vladimir Vukicevic, Milena Vukic, Nenad Vukovic, Nevena Milivojevic, Marko Zivanovic, Vladimir Jakovljevic, Nenad Filipovic, Dejan Baskic, Natasa Djordjevic
Summary: This study investigated the association of IFNL3 and IFNL4 polymorphisms with COVID-19 mortality, and found that increased CCI, N/L, and LDH level were associated with a lethal outcome. Additionally, females and patients with at least one variant allele of IFNL3 rs8099917 were almost 36 times more likely to survive SARS-CoV-2 infection, while the presence of at least one ancestral allele of IFNL4 rs368234815 decreased the likelihood of mortality from COVID-19 by more than 15-fold.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Marko Zivanovic, Marina Gazdic Jankovic, Amra Ramovic Hamzagic, Katarina Virijevic, Nevena Milivojevic, Katarina Pecic, Dragana Seklic, Milena Jovanovic, Nikolina Kastratovic, Ana Miric, Tijana Dukic, Ivica Petrovic, Vladimir Jurisic, Biljana Ljujic, Nenad Filipovic
Summary: Nowadays, biomedicine is a multidisciplinary science that requires a broad approach to better understand human health. This study uses numerical simulations to investigate cancer viability and apoptosis in treatment with commercial chemotherapeutics. Through experiments and numerical modeling, the study reveals the decrease in viability and the predominance of late apoptosis in the treatment, offering a new perspective on the problem.
Article
Chemistry, Applied
Aleksandar Mijatovic, Angelina Z. Cakovic, Aleksandar Lolic, Olivera Klisuric, Marko N. Zivanovic, Dragana S. Seklic, Snezana Sretenovic, Marija Ilic, Jovana Bogojeski
Summary: This study synthesized multiple copper (II) complexes with different ligands and investigated their interactions with DNA and proteins, as well as their anti-tumor activity. The results showed that these complexes had moderate affinity for DNA and proteins, and one of the complexes exhibited selectivity for cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Correction
Pharmacology & Pharmacy
Safi Ur Rehman Qamar, Lemana Spahic, Leo Benolic, Marko Zivanovic, Nenad Filipovic
Article
Food Science & Technology
Milena M. Jovanovic, Katarina G. Markovic, Mirjana Z. Grujovic, Jelena Pavic, Milan Mitic, Jelena Nikolic, Dragana Seklic
Summary: Laetiporus sulphureus is a well-known edible mushroom with beneficial effects on human wellness. The phenolic profile of its ethanolic extract was determined, and its effects on probiotic cultures and cancer cells were evaluated. The extract showed low tolerance on probiotic strains and significant antimigratory activity on cancer cells. It has the potential to be used as a natural protector of probiotics and as a suppressor of cancer cell motility.
FOOD SCIENCE & NUTRITION
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)