Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer

Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells

(2021) Soha H. Emam et al.   BIOORGANIC CHEMISTRY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using β-aroylpyruvates as synthons

(2021) Afaf El-Malah et al.   Green Chemistry Letters and Reviews

Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition

(2021) Yara El-Dash et al.   BIOORGANIC CHEMISTRY

Isatin-Schiff's base and chalcone hybrids as chemically apoptotic inducers and EGFR inhibitors; design, synthesis, anti-proliferative activities and in silico evaluation

(2021) Eman A. Fayed et al.   JOURNAL OF MOLECULAR STRUCTURE

Decreased abundance of GDNF mRNA transcript in the immature Sertoli cells of cattle in response to protein kinase inhibitor staurosporine

(2020) Yu Jiang et al.   ANIMAL REPRODUCTION SCIENCE

Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors

(2020) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Chalcone synthesis, properties and medicinal applications: a review

(2020) Aluru Rammohan et al.   Environmental Chemistry Letters

1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226

(2020) Heba F. Ashour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New chalcone-type compounds and 2-pyrazoline derivatives: synthesis and caspase-dependent anticancer activity

(2020) Mohamed I Chouiter et al.   Future Medicinal Chemistry

Antiproliferative Effect of Acridine Chalcone Is Mediated by Induction of Oxidative Stress

(2020) Peter Takac et al.   Biomolecules

New halogenated chalcones with cytotoxic and carbonic anhydrase inhibitory properties: 6-(3-Halogenated phenyl-2-propen-1-oyl)-2(3H )-benzoxazolones

(2020) Sinan Bilginer et al.   ARCHIV DER PHARMAZIE

Pyrazoline Hybrids as Promising Anticancer Agents: An Up-to-Date Overview

(2020) Dimitris Matiadis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase

(2020) Sri Devi Sukumaran et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression

(2019) Sourabh Soni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Synthesis of 5-(4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzylidene)thiazolidine-2,4-dione as promising DNA and serum albumin-binding agents and evaluation of antitumor activity

(2019) Iqubal Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds

(2019) Omaima M. Abdelhafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site

(2019) Guangcheng Wang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

(2019) Wenjia Dan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microbial Transformation of Licochalcones

(2019) Yina Xiao et al.   MOLECULES

Synthesis and biological evaluation of novel chalcones bearing morpholine moiety as antiproliferative agents

(2018) BEDRİYE SEDA KURŞUN AKTAR et al.   TURKISH JOURNAL OF CHEMISTRY

Exploitation of new chalcones and 4H-chromenes as agents for cancer treatment

(2018) Olívia Pontes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Expanding the medicinal chemistry synthetic toolbox

(2018) Jonas Boström et al.   NATURE REVIEWS DRUG DISCOVERY

6′-Benzyloxy-4-bromo-2′-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis

(2018) Ester Saavedra et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity

(2018) Umut Salgin Goksen et al.   CHIRALITY

Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A

(2017) Charlotte Simmler et al.   FITOTERAPIA

Halogenated naphthochalcones and structurally related naphthopyrazolines with antitumor activity

(2016) Florian Schmitt et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Review on Mechanisms of Anti Tumor Activity of Chalcones

(2015) Rahul Sharma et al.   Anti-Cancer Agents in Medicinal Chemistry

Structure-based design, structure–activity relationship analysis, and antitumor activity of diaryl ether derivatives

(2015) Shao-Mei Yang et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

(2015) Muhammed Karabacak et al.   MOLECULES

Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents

(2014) Koneni V. Sashidhara et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

Design and Development of Halogenated Chalcone Derivatives as Potential Anticancer Agents

(2014) UK Jain et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin

(2013) Tatiana A. Dias et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caffeic acid phenethyl ester synergistically enhances docetaxel and paclitaxel cytotoxicity in prostate cancer cells

(2013) Mai F. Tolba et al.   IUBMB LIFE

Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents

(2012) Hui Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cis-enone Resorcylic Acid Lactones (RALs) as Irreversible Protein Kinase Inhibitors

(2012) Linyi Wei et al.   CURRENT DRUG METABOLISM

A New Class of Anticonvulsants Possessing 6 Hz Psychomotor Seizure Test Activity: 2-(1H-Benzotriazol-1-yl)-N'-[Substituted] Acetohydrazides

(2012) Praveen Kumar et al.   Medicinal Chemistry

Diaryl ether derivatives as anticancer agents – a review

(2012) Florence Bedos-Belval et al.   MedChemComm

Diaryl Ether Formation in the Synthesis of Natural Products

(2011) Emmanuel N. Pitsinos et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry

(2011) Thomas Mendgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity of some new pyrazoline and pyrimidine derivatives

(2011) Seham Y Hassan   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

The Coupling of Arylboronic Acids with Nitroarenes Catalyzed by Rhodium

(2011) Xingwang Zheng et al.   ORGANIC LETTERS

Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells

(2010) Palak Parekh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism

(2010) Julia Strathmann et al.   FASEB JOURNAL

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Redox Regulation in Cancer: A Double-edged Sword with Therapeutic Potential

(2010) Asha Acharya et al.   Oxidative Medicine and Cellular Longevity

2,6,8-Trisubstituted 3-Hydroxychromone Derivatives as Fluorophores for Live-Cell Imaging

(2009) Christine Dyrager et al.   CHEMISTRY-A EUROPEAN JOURNAL