A nanoplatform to boost multi-phases of cancer-immunity-cycle for enhancing immunotherapy

A Multifunctional Nanovaccine based on L‐Arginine‐Loaded Black Mesoporous Titania: Ultrasound‐Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy

(2021) Meifang Wang et al.   Small

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

(2021) Chao Wang et al.   JOURNAL OF CONTROLLED RELEASE

Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction

(2020) Joseph Vanderburgh et al.   ACS Nano

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

(2020) Rebecca A. Luchtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-dose vitamin C enhances cancer immunotherapy

(2020) Alessandro Magrì et al.   Science Translational Medicine

Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy

(2020) Jingyi An et al.   ACS Nano

Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

(2020) Ziliang Dong et al.   Chem

An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment

(2020) Mohamed Attia et al.   Antioxidants

pH and glutathione dual responsive nanoparticles based on Ganoderma lucidum polysaccharide for potential programmable release of three drugs

(2020) Dan Zheng et al.   CHEMICAL ENGINEERING JOURNAL

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Multifunctional FeS2 theranostic nanoparticles for photothermal-enhanced chemodynamic/photodynamic cancer therapy and photoacoustic imaging

(2020) Shuting Xiao et al.   CHEMICAL ENGINEERING JOURNAL

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

(2020) Lang Rao et al.   Nature Communications

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Sodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

(2019) Hanan Abumanhal-Masarweh et al.   JOURNAL OF CONTROLLED RELEASE

Quercetin-Modified Metal–Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX

(2019) Tengchuang Ma et al.   ACS Nano

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

(2019) Paul C. McDonald et al.   GASTROENTEROLOGY

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically

(2019) Shawn C Chafe et al.   Cancer Immunology Research

Boosting the Ferroptotic Antitumor Efficacy via Site-specific Amplification of Tailored Lipid Peroxidation

(2019) Yang An et al.   ACS Applied Materials & Interfaces

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

A Three-in-One Immunotherapy Nanoweapon via Cascade-Amplifying Cancer-Immunity Cycle against Tumor Metastasis, Relapse, and Postsurgical Regrowth

(2019) Qian Li et al.   NANO LETTERS

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Enhanced Intracellular Ca2+ Nanogenerator for Tumor-Specific Synergistic Therapy via Disruption of Mitochondrial Ca2+ Homeostasis and Photothermal Therapy

(2018) Lihua Xu et al.   ACS Nano

Near-Infrared Upconversion Mesoporous Cerium Oxide Hollow Biophotocatalyst for Concurrent pH-/H2 O2 -Responsive O2 -Evolving Synergetic Cancer Therapy

(2018) Chi Yao et al.   ADVANCED MATERIALS

Nanoparticle-mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

(2018) Xiaopin Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

(2018) Xinxin Song et al.   GASTROENTEROLOGY

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Hypoxia and acidosis: immune suppressors and therapeutic targets

(2018) Sultan Damgaci et al.   IMMUNOLOGY

Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity

(2018) Ziliang Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulation of Ca2+ Signaling for Drug-Resistant Breast Cancer Therapy with Mesoporous Silica Nanocapsule Encapsulated Doxorubicin/siRNA Cocktail

(2018) Shu Wang et al.   ACS Nano

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

cGAS/STING Pathway in Cancer: Jekyll and Hyde Story of Cancer Immune Response

(2017) Debojit Bose   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer

(2017) Takahiro Karasaki et al.   Journal of Thoracic Oncology

Cancer Immunotherapy: From local to global

(2017) Willem J. M. Mulder et al.   Nature Nanotechnology

In situ mineralization of anticancer drug into calcium carbonate monodisperse nanospheres and their pH-responsive release property

(2016) Tiezhu Yang et al.   Materials Science & Engineering C-Materials for Biological Applications

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8+ memory T cell production capacity of these cells in vivo

(2014) Young-Joo Jeong et al.   IMMUNOBIOLOGY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Palmitoyl Ascorbate Liposomes and Free Ascorbic Acid: Comparison of Anticancer Therapeutic Effects Upon Parenteral Administration

(2011) Rupa R. Sawant et al.   PHARMACEUTICAL RESEARCH