High-dose vitamin C enhances cancer immunotherapy

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

(2020) Rebecca A. Luchtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors

(2019) Patrick Arnaud-Coffin et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

(2019) Feng Wang et al.   BMC CANCER

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy

(2019) Yan-ping Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo

(2018) Nigel G. Kooreman et al.   Cell Stem Cell

Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer

(2018) Michael J. Overman et al.   JOURNAL OF CLINICAL ONCOLOGY

Nivolumab Plus Ipilimumab in Patients With Advanced Melanoma: Updated Survival, Response, and Safety Data in a Phase I Dose-Escalation Study

(2018) Margaret K. Callahan et al.   JOURNAL OF CLINICAL ONCOLOGY

Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden

(2018) Matthew D. Hellmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

(2018) Niraj Shenoy et al.   CANCER CELL

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge

(2018) Anitra C. Carr et al.   Frontiers in Physiology

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

(2018) S Adams et al.   ANNALS OF ONCOLOGY

The role of vitamin C in the treatment of pain: new insights

(2017) Anitra C. Carr et al.   Journal of Translational Medicine

Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

(2017) Michael J Overman et al.   LANCET ONCOLOGY

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

(2017) Giovanni Germano et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

(2017) Joaquim Bellmunt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Vitamin C and Immune Function

(2017) Anitra Carr et al.   Nutrients

Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

(2016) Maud-Emmanuelle Gilles et al.   CANCER RESEARCH

Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer

(2016) Jing Liu et al.   CANCER RESEARCH

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

(2016) Elizabeth J. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice

(2016) Alice Elizabeth Kane et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

Vitamin C: the known and the unknown and Goldilocks

(2016) SJ Padayatty et al.   ORAL DISEASES

Regulation of the Epigenome by Vitamin C

(2015) Juan I. Young et al.   Annual Review of Nutrition

Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model

(2015) Oscar K. Serrano et al.   FREE RADICAL BIOLOGY AND MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8+ memory T cell production capacity of these cells in vivo

(2014) Young-Joo Jeong et al.   IMMUNOBIOLOGY

Ascorbic Acid: Its Role in Immune System and Chronic Inflammation Diseases

(2014) Angela Sorice et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING