Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

PEGylated liposomes: immunological responses

(2019) Marwa Mohamed et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Remote-loading of liposomes with manganese-52 and in vivo evaluation of the stabilities of 52 Mn-DOTA and 64 Cu-DOTA using radiolabelled liposomes and PET imaging

(2018) Andreas I. Jensen et al.   JOURNAL OF CONTROLLED RELEASE

Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy

(2018) S. Elizabeth Franks et al.   Frontiers in Immunology

TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells

(2017) Amy N. Suthers et al.   Frontiers in Immunology

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

(2016) Thomas J. Povsic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein

(2015) Yu Mima et al.   MOLECULAR PHARMACEUTICS

Non-CpG Oligonucleotides Exert Adjuvant Effects by Enhancing Cognate B Cell-T Cell Interactions, Leading to B Cell Activation, Differentiation, and Isotype Switching

(2015) Melinda Herbáth et al.   Journal of Immunology Research

Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin

(2014) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

DNA Nanocarriers for Systemic Administration: Characterization and In Vivo Bioimaging in Healthy Mice

(2013) Stephanie David et al.   Molecular Therapy-Nucleic Acids

B cell TLRs and induction of immunoglobulin class-switch DNA recombination

(2012) Egest et al.   Frontiers in Bioscience-Landmark

Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon

(2012) Taro Shimizu et al.   IMMUNOBIOLOGY

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application

(2012) Ai Nagao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Trial watch: FDA-approved Toll-like receptor agonists for cancer therapy

(2012) Erika Vacchelli et al.   OncoImmunology

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular underpinning of B-cell anergy

(2010) Yuval Yarkoni et al.   IMMUNOLOGICAL REVIEWS

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

(2010) Hiroyuki Koide et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats

(2010) Masako Ichihara et al.   Pharmaceutics

CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes

(2009) Tatsuaki Tagami et al.   JOURNAL OF CONTROLLED RELEASE

Comparison of human B cell activation by TLR7 and TLR9 agonists

(2008) John A Hanten et al.   BMC IMMUNOLOGY

Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes

(2007) Tatsuhiro Ishida et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS