CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

(2020) Loreto Martínez-González et al.   Scientific Reports

A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum–associated degradation

(2019) Junfen Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

(2018) Laura M. Taylor et al.   Molecular Neurodegeneration

Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

(2018) Xing Sun et al.   Cell Death & Disease

The role of CHMP2BIntron5 in autophagy and frontotemporal dementia

(2016) Christopher S. Krasniak et al.   BRAIN RESEARCH

A transgenic mouse expressing CHMP2Bintron5mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia

(2016) Aurélia Vernay et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43

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Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

(2016) Carolina Alquezar et al.   Molecular Neurodegeneration

Phosphorylated TDP-43 becomes resistant to cleavage by calpain: A regulatory role for phosphorylation in TDP-43 pathology of ALS/FTLD

(2016) Takenari Yamashita et al.   NEUROSCIENCE RESEARCH

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

(2015) Emma L. Clayton et al.   ACTA NEUROPATHOLOGICA

Casein kinases as potential therapeutic targets

(2015) Giorgio Cozza et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Role of TDP-43 in Alzheimer’s Disease

(2015) Xiao-Long Chang et al.   MOLECULAR NEUROBIOLOGY

Casein kinase 1 and Wnt/β-catenin signaling

(2014) Cristina-Maria Cruciat   CURRENT OPINION IN CELL BIOLOGY

Protein Kinase CK-1 Inhibitors As New Potential Drugs for Amyotrophic Lateral Sclerosis

(2014) Irene G. Salado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activity-Induced Nr4a1 Regulates Spine Density and Distribution Pattern of Excitatory Synapses in Pyramidal Neurons

(2014) Yelin Chen et al.   NEURON

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

(2014) Nicole F. Liachko et al.   PLoS Genetics

TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo

(2013) Darshana K. Choksi et al.   HUMAN MOLECULAR GENETICS

Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion

(2013) Lei-Lei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

TDP-43 pathology in polyglutamine diseases: With reference to amyotrphic lateral sclerosis

(2013) Yasuko Toyoshima et al.   NEUROPATHOLOGY

Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice

(2012) Shabnam Ghazi-Noori et al.   BRAIN

Frontotemporal Dementia Caused by CHMP2B Mutations

(2011) A. M. Isaacs et al.   Current Alzheimer Research

The ESCRT Pathway

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Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

(2011) Edward B. Lee et al.   NATURE REVIEWS NEUROSCIENCE

Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation

(2011) Huei-Ying Li et al.   PLoS One

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

(2011) Todd J. Cohen et al.   TRENDS IN MOLECULAR MEDICINE

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations

(2010) Hazel Urwin et al.   HUMAN MOLECULAR GENETICS

Casein kinase 1: Complexity in the family

(2010) Jit Kong Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy

(2010) N. F. Liachko et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

(2010) Yong-Jie Zhang et al.   Molecular Neurodegeneration

TAR DNA-binding protein 43 in neurodegenerative disease

(2010) Alice S. Chen-Plotkin et al.   Nature Reviews Neurology

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

(2009) Tetsuaki Arai et al.   ACTA NEUROPATHOLOGICA

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

(2009) Manuela Neumann et al.   ACTA NEUROPATHOLOGICA

Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III

(2009) Jin-A Lee et al.   Autophagy

Identification of casein kinase-1 phosphorylation sites on TDP-43

(2009) Fuyuki Kametani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of CHMP2B in frontotemporal dementia

(2009) Hazel Urwin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

(2009) J.-A Lee et al.   JOURNAL OF NEUROSCIENCE

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

(2009) S. T. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2008) Masato Hasegawa et al.   ANNALS OF NEUROLOGY