The Role of TDP-43 in Alzheimer’s Disease

TARDBP Mutation Analysis in TDP-43 Proteinopathies and Deciphering the Toxicity of Mutant TDP-43

(2018) Tania F. Gendron et al.   JOURNAL OF ALZHEIMERS DISEASE

Contribution of TARDBP to Alzheimer's Disease Genetic Etiology

(2017) Nathalie Brouwers et al.   JOURNAL OF ALZHEIMERS DISEASE

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes

(2015) Eliana Lauranzano et al.   BRAIN

TDP-43 as a Modulator of Synaptic Plasticity in a Mouse Model of Spinal Motoneuron Degeneration

(2015) Rosario Gulino et al.   CNS & Neurological Disorders-Drug Targets

Biomarkers in the diagnosis and management of Alzheimer’s disease

(2015) Richard Wurtman   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism

(2015) Lies Vanden Broeck et al.   NEUROBIOLOGY OF AGING

Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

(2015) C.H. Latta et al.   NEUROSCIENCE

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

(2015) Anna-Claire Devlin et al.   Nature Communications

Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

(2014) Mark Yarchoan et al.   ACTA NEUROPATHOLOGICA

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Is synaptic loss a unique hallmark of Alzheimer's disease?

(2014) Stephen W. Scheff et al.   BIOCHEMICAL PHARMACOLOGY

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43

(2014) Archi Joardar et al.   HUMAN MOLECULAR GENETICS

TAR DNA-binding protein 43 pathology in Alzheimer's disease with psychosis

(2014) Anil Varma V. Vatsavayi et al.   INTERNATIONAL PSYCHOGERIATRICS

Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43

(2014) Carola Stribl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human andDrosophilaTAR DNA-binding Protein 43 (TDP-43)

(2014) Maurizio Romano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

TDP-43 in Alzheimer’s disease is not associated with clinical FTLD or Parkinsonism

(2014) Youngsin Jung et al.   JOURNAL OF NEUROLOGY

Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion inC9orf72

(2014) Leeanne McGurk et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor forTNF-αexpression upon lipopolysaccharide stimulation in human monocytes

(2014) H. Murata et al.   JOURNAL OF PERIODONTAL RESEARCH

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

Significance and limitation of the pathological classification of TDP-43 proteinopathy

(2014) Tetsuaki Arai   NEUROPATHOLOGY

No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease

(2014) Andrew C. Robinson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

TDP-43 interaction with the intracellular domain of amyloid precursor protein induces p53-associated apoptosis

(2014) Jing Wang et al.   NEUROSCIENCE LETTERS

The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

(2014) P.-H. Kuo et al.   NUCLEIC ACIDS RESEARCH

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

(2014) J. A. Austin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis

(2014) Vedrana Tadic et al.   Frontiers in Cellular Neuroscience

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

(2014) Yu-Sheng Fang et al.   Nature Communications

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

(2014) Nicole F. Liachko et al.   PLoS Genetics

Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases

(2014) Emily Feneberg et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients

(2013) Takenari Yamashita et al.   BRAIN RESEARCH

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

(2013) Danielle C. Diaper et al.   HUMAN MOLECULAR GENETICS

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

(2013) Guilian Xu et al.   HUMAN MOLECULAR GENETICS

The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons

(2013) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

(2013) Yong-Jie Zhang et al.   HUMAN MOLECULAR GENETICS

TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress

(2013) Shinji Higashi et al.   JOURNAL OF NEUROCHEMISTRY

Calcium Channel Agonists Protect against Neuromuscular Dysfunction in a Genetic Model of TDP-43 Mutation in ALS

(2013) G. A. B. Armstrong et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice

(2013) David X. Medina et al.   NEUROBIOLOGY OF AGING

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo

(2013) Alexandra Vaccaro et al.   NEUROBIOLOGY OF DISEASE

TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

(2013) Lies Vanden Broeck et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice

(2012) I-Fang Wang et al.   Autophagy

Mitochondrial dysfunction in human TDP-43 transfected NSC34 cell lines and the protective effect of dimethoxy curcumin

(2012) Jinsheng Lu et al.   BRAIN RESEARCH BULLETIN

TDP-43: A new player on the AD field?

(2012) Katherine L. Youmans et al.   EXPERIMENTAL NEUROLOGY

Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models

(2012) Alexander M. Herman et al.   EXPERIMENTAL NEUROLOGY

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

(2012) Lauren Herl Martens et al.   JOURNAL OF CLINICAL INVESTIGATION

TARDBP mutations in Parkinson's disease

(2012) Sruti Rayaprolu et al.   PARKINSONISM & RELATED DISORDERS

Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio

(2012) Alexandra Vaccaro et al.   PLoS One

Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila

(2012) Dennis J. Hazelett et al.   G3-Genes Genomes Genetics

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain

(2012) Ramesh K. Narayanan et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

(2011) Johannes Brettschneider et al.   ACTA NEUROPATHOLOGICA

β-Amyloid triggers ALS-associated TDP-43 pathology in AD models

(2011) Alexander M. Herman et al.   BRAIN RESEARCH

The Seeds of Neurodegeneration: Prion-like Spreading in ALS

(2011) Magdalini Polymenidou et al.   CELL

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast

(2011) Ralf J. Braun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin and TDP-43: Mechanistic Links and Future Directions

(2011) Samir Kumar-Singh   JOURNAL OF MOLECULAR NEUROSCIENCE

TAR-DNA binding protein-43 and alterations in the hippocampus

(2011) Tuomas Rauramaa et al.   JOURNAL OF NEURAL TRANSMISSION

Accumulation of Transactive Response DNA Binding Protein 43 in Mild Cognitive Impairment and Alzheimer Disease

(2011) Cyntia Tremblay et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

(2011) Vinay K. Godena et al.   PLoS One

Zinc induces depletion and aggregation of endogenous TDP-43

(2010) Aphrodite Caragounis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial biology in Alzheimer’s disease pathogenesis

(2010) María F. Galindo et al.   JOURNAL OF NEUROCHEMISTRY

Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

(2010) Y.-F. Xu et al.   JOURNAL OF NEUROSCIENCE

Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation

(2010) Antonella Caccamo et al.   Molecular Neurodegeneration

TDP43-Positive Intraneuronal Inclusions in a Patient with Motor Neuron Disease and Parkinson’s Disease

(2010) Jean-Baptiste Chanson et al.   Neurodegenerative Diseases

Novel CSF biomarkers for frontotemporal lobar degenerations

(2010) W. T. Hu et al.   NEUROLOGY

Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis

(2010) Shoichi Sasaki et al.   NEUROSCIENCE LETTERS

Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration

(2009) Penelope G. Foulds et al.   ACTA NEUROPATHOLOGICA

Inhibition of γ-secretase activity reduces Aβ production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease

(2009) Baiyang Sheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

(2009) G. S. Pesiridis et al.   HUMAN MOLECULAR GENETICS

Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies

(2009) Lionel M. Igaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational analysis of TARDBP in neurodegenerative diseases

(2009) Nicola Ticozzi et al.   NEUROBIOLOGY OF AGING

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

(2009) A. D'Ambrogio et al.   NUCLEIC ACIDS RESEARCH

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

(2009) I. Wegorzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer’s disease and frontotemporal lobar degeneration

(2008) Penelope Foulds et al.   ACTA NEUROPATHOLOGICA

Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease

(2008) Troy T. Rohn   BRAIN RESEARCH

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

(2008) Kunihiro Uryu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype

(2008) K. A. Josephs et al.   NEUROLOGY

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

(2007) Emanuele Buratti   Frontiers in Bioscience-Landmark