Oxidative stress induces Z-DNA-binding protein 1–dependent activation of microglia via mtDNA released from retinal pigment epithelial cells

IRGM1 links mitochondrial quality control to autoimmunity

(2021) Prashant Rai et al.   NATURE IMMUNOLOGY

The cell biology of the retinal pigment epithelium

(2020) Aparna Lakkaraju et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

(2020) Michael Devos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

(2019) Kai Kaarniranta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Retinal Degeneration

(2019) Khalid Rashid et al.   Frontiers in Immunology

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Retinal pigment epithelium polarity in health and blinding diseases

(2019) Paulo S Caceres et al.   CURRENT OPINION IN CELL BIOLOGY

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

(2018) Teneema Kuriakose et al.   TRENDS IN IMMUNOLOGY

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

(2018) Bartosz Szczesny et al.   Scientific Reports

Microglia in the Retina: Roles in Development, Maturity, and Disease

(2018) Sean M. Silverman et al.   Annual Review of Vision Science

DNA polymerases in the mitochondria A critical review of the evidence

(2017) William C Copeland   Frontiers in Bioscience-Landmark

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

(2017) Nagaraj Kerur et al.   NATURE MEDICINE

Roles of exosomes in the normal and diseased eye

(2017) Mikael Klingeborn et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

(2017) Deborah A. Ferrington et al.   Redox Biology

Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers

(2017) Mikael Klingeborn et al.   Scientific Reports

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

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Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

(2015) Christian Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-Dependent and Organ-Specific Changes in Mitochondrial Function, Mitochondrial DNA Integrity, Oxidative Stress and Mononuclear Cell Infiltration in a Mouse Model of Burn Injury

(2015) Bartosz Szczesny et al.   PLoS One

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

(2014) Bartosz Szczesny et al.   NUCLEIC ACIDS RESEARCH

Nrf2 signaling is impaired in the aging RPE given an oxidative insult

(2013) Mira M. Sachdeva et al.   EXPERIMENTAL EYE RESEARCH

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration

(2013) Janusz Blasiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage

(2013) Bartosz Szczesny et al.   PLoS One

Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

(2012) Amy M. Furda et al.   DNA REPAIR

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury

(2011) Yu X. G. Kong et al.   AGING CELL

Retinitis Pigmentosa: Genes and Disease Mechanisms

(2011) Francesco Parmeggiani et al.   CURRENT GENOMICS

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

Dynamics of H2O2 availability to ARPE-19 cultures in models of oxidative stress

(2010) Patrycja Kaczara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

(2010) Bartosz Szczesny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells

(2010) Parameswaran G. Sreekumar et al.   PLoS One

Glucose oxidase: natural occurrence, function, properties and industrial applications

(2008) Chun Ming Wong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina

(2008) Ai Ling Wang et al.   NEUROBIOLOGY OF AGING