Transport and Interactions of Co-incubated Bi-functional Flavonoids through Inhibiting the Function of P-Glycoprotein (P-gp) Using KB/Multidrug-Resistant (MDR) Cells and Rat Everted Gut Sacs

Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells

(2021) Yajing Fang et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary Tangeretin Alleviated Dextran Sulfate Sodium-Induced Colitis in Mice via Inhibiting Inflammatory Response, Restoring Intestinal Barrier Function, and Modulating Gut Microbiota

(2021) Bin Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular pharmacokinetic mechanism of the drug-drug interaction between genistein and repaglinide mediated by P-gp

(2020) Huan Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of Different Dietary Flavonoids on Dipeptidyl Peptidase-IV Activity and Expression: Insights into Structure–Activity Relationship

(2020) Fengyi Gao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Establishment and Use of Human Mouth Epidermal Carcinoma (KB) Cells Overexpressing P-Glycoprotein To Characterize Structure Requirements for Flavonoids Transported by the Efflux Transporter

(2019) Yajing Fang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure affinity relationship and docking studies of flavonoids as substrates of multidrug-resistant associated protein 2 (MRP2) in MDCK/MRP2 cells

(2019) Yajing Fang et al.   FOOD CHEMISTRY

Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure–activity relationships

(2019) Jie Bai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Anti-inflammatory effects of flavonoids

(2019) Soheila J. Maleki et al.   FOOD CHEMISTRY

Inhibition of P-Glycoprotein Mediated Efflux in Caco-2 Cells by Phytic Acid

(2018) Lujia Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies

(2018) Zhong-Wen Yuan et al.   PHARMACOLOGICAL RESEARCH

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Combined cereal and pulse flavonoids show enhanced bioavailability by downregulating phase II metabolism and ABC membrane transporter function in Caco-2 model

(2018) Shreeya Ravisankar et al.   FOOD CHEMISTRY

Study of Structure and Permeability Relationship of Flavonoids in Caco-2 Cells

(2017) Yajing Fang et al.   Nutrients

Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer

(2016) S. Mohana et al.   Molecular BioSystems

3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors

(2016) Yajing Fang et al.   Scientific Reports

Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs

(2016) D. Ravikumar Reddy et al.   SpringerPlus

Buckwheat as a Functional Food and Its Effects on Health

(2015) Juan Antonio Giménez-Bastida et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Improving the estimation of flavonoid intake for study of health outcomes

(2015) Julia J. Peterson et al.   NUTRITION REVIEWS

Computational models for predicting substrates or inhibitors of P-glycoprotein

(2011) Lei Chen et al.   DRUG DISCOVERY TODAY

Intra-herb pharmacokinetics interaction between quercetin and isorhamentin

(2009) Ke Lan et al.   ACTA PHARMACOLOGICA SINICA

Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp

(2009) Xiao-dan Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response

(2009) Ana I. Alvarez et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular models of human P-glycoprotein in two different catalytic states

(2009) Jean-Paul Becker et al.   BMC STRUCTURAL BIOLOGY